spironolactone has been researched along with Polyuria in 8 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Polyuria: Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thereafter, spironolactone treatment successfully ameliorated hyperaldosteronism for 7 years with no discernible adrenal enlargement." | 4.90 | Discordant genotype-phenotype correlation in familial hyperaldosteronism type III with KCNJ5 gene mutation: a patient report and review of the literature. ( Adachi, M; Asakura, Y; Hasegawa, T; Homma, K; Muroya, K; Sugiyama, K, 2014) |
| "These features were consistent with the Gitelman syndrome." | 1.56 | Systemic lupus erythematosus complicated by a Gitelman-like syndrome in an 8-year-old girl. ( Barathidasan, GS; Dhandapany, G; Ganesh, RN; Karunakar, P; Krishnamurthy, S; Rajendran, R; Ramamoorthy, JG; Ramya, K, 2020) |
| "KCNMB2(-/-) mice displayed hyperaldosteronism, normal plasma K(+) concentration, and produced dilute urine with decreased K(+) concentration." | 1.43 | Hyperaldosteronism after decreased renal K+ excretion in KCNMB2 knockout mice. ( Bleich, M; de Bruijn, PI; Jensen, IS; Larsen, CK; Leipziger, J; Praetorius, HA; Sorensen, MV, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Barathidasan, GS | 1 |
| Krishnamurthy, S | 1 |
| Karunakar, P | 1 |
| Rajendran, R | 1 |
| Ramya, K | 1 |
| Dhandapany, G | 1 |
| Ramamoorthy, JG | 1 |
| Ganesh, RN | 1 |
| Adachi, M | 1 |
| Muroya, K | 1 |
| Asakura, Y | 1 |
| Sugiyama, K | 1 |
| Homma, K | 1 |
| Hasegawa, T | 1 |
| Larsen, CK | 1 |
| Jensen, IS | 1 |
| Sorensen, MV | 1 |
| de Bruijn, PI | 1 |
| Bleich, M | 1 |
| Praetorius, HA | 1 |
| Leipziger, J | 1 |
| ROYER, P | 1 |
| DELAITRE, R | 1 |
| MATHIEU, H | 1 |
| GABILAN, JC | 1 |
| RAYNAUD, C | 1 |
| PASQUALINI, JR | 1 |
| DEBRIS, P | 1 |
| GERBEAUX, S | 1 |
| HABIB, R | 1 |
| HERBEUVAL, R | 1 |
| CUNY, G | 1 |
| GUERICI, O | 1 |
| BARBIER, JM | 1 |
| JANDEAUX, M | 1 |
| Fujii, M | 1 |
| Suto, H | 1 |
| Goto, M | 1 |
| Miki, Y | 1 |
| Asai, N | 1 |
| de Groot, CA | 1 |
| Radó, JP | 1 |
| Takó, J | 1 |
| Hammer, C | 1 |
| Szilágyi, L | 1 |
1 review available for spironolactone and Polyuria
| Article | Year |
|---|---|
Discordant genotype-phenotype correlation in familial hyperaldosteronism type III with KCNJ5 gene mutation: a patient report and review of the literature.
Topics: Adrenal Glands; Amino Acid Substitution; Child, Preschool; G Protein-Coupled Inwardly-Rectifying Pot | 2014 |
7 other studies available for spironolactone and Polyuria
| Article | Year |
|---|---|
Systemic lupus erythematosus complicated by a Gitelman-like syndrome in an 8-year-old girl.
Topics: Alkalosis; Child; Cyclophosphamide; Drug Therapy, Combination; Female; Gitelman Syndrome; Humans; Hy | 2020 |
Hyperaldosteronism after decreased renal K+ excretion in KCNMB2 knockout mice.
Topics: Aldosterone; Animals; Blood Pressure; Epithelial Sodium Channels; Eplerenone; Female; Hyperaldostero | 2016 |
[CHRONIC IDIOPATHIC HYPOKALEMIA WITH HYPERKALIURIA IN CHILDREN].
Topics: Adrenal Glands; Aldosterone; Blood Platelet Disorders; Blood Platelets; Child; Corticosterone; Dwarf | 1964 |
[POLYURO-POLYDIPSIC SYNDROME AND CIRRHOSIS. (DISCUSSION APROPOS OF A CASE)].
Topics: Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Diuretics; Humans; Liver Cirrhosis; Polyuria; Sp | 1964 |
[Water-electrolyte imbalance: Reality in diagnosis and therapy (discussion)].
Topics: Acid-Base Equilibrium; Acidosis; Diagnosis, Differential; Extracellular Fluid; Humans; Hypercalcemia | 2006 |
Effects of spironolactone and adrenalectomy on the antipolyuric action of chlorothiazide in Brattleboro rats [proceedings].
Topics: Adrenalectomy; Animals; Chlorothiazide; Diabetes Insipidus; Polyuria; Rats; Spironolactone | 1979 |
[On the effect of aldosterone and aldactone A on various segments of kidney tubules in Cushing's syndrome with polyuria].
Topics: Aldosterone; Cushing Syndrome; Desoxycorticosterone; Humans; Hydrocortisone; Kidney Tubules; Polyuri | 1965 |