spironolactone has been researched along with Periodontitis in 1 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In part 1 the endotoxic shock model showed a significant reduction in TNF levels in the spironolactone-treated group compared to the non-treated group, suggesting that spironolactone acts as a TNF inhibitor." | 5.33 | The effect of spironolactone on experimental periodontitis in rats. ( Bendtzen, K; Bentzen, BH; Björnsson, M; Grauballe, MC; Holmstrup, P; Jonassen, TE; Moe, D; Stoltze, K, 2005) |
| "In part 1 the endotoxic shock model showed a significant reduction in TNF levels in the spironolactone-treated group compared to the non-treated group, suggesting that spironolactone acts as a TNF inhibitor." | 1.33 | The effect of spironolactone on experimental periodontitis in rats. ( Bendtzen, K; Bentzen, BH; Björnsson, M; Grauballe, MC; Holmstrup, P; Jonassen, TE; Moe, D; Stoltze, K, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grauballe, MC | 1 |
| Bentzen, BH | 1 |
| Björnsson, M | 1 |
| Moe, D | 1 |
| Jonassen, TE | 1 |
| Bendtzen, K | 1 |
| Stoltze, K | 1 |
| Holmstrup, P | 1 |
1 other study available for spironolactone and Periodontitis
| Article | Year |
|---|---|
The effect of spironolactone on experimental periodontitis in rats.
Topics: Administration, Oral; Alveolar Bone Loss; Animals; Lipopolysaccharides; Male; Maxillary Diseases; Pe | 2005 |