spironolactone has been researched along with Palsy in 26 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case is reported of an adult who presented with hyperkalaemic muscular paralysis induced by spironolactone." | 7.66 | Hyperkalaemic paralysis due to spironolactone. ( Harrold, BP; Udezue, EO, 1980) |
| " With the discontinuation of the licorice-containing medicines and administration of spironolactone together with intravenous and oral potassium supplement, her serum potassium level was normalized and her clinical symptoms and hypertension improved within 2 weeks." | 3.74 | Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice. ( Harada, E; Itoh, T; Mizuno, Y; Yasue, H, 2007) |
| "A case is reported of an adult who presented with hyperkalaemic muscular paralysis induced by spironolactone." | 3.66 | Hyperkalaemic paralysis due to spironolactone. ( Harrold, BP; Udezue, EO, 1980) |
| "Acquired Gitelman syndrome is a very rare disorder reported in association with autoimmune disorders, mostly Sjögren syndrome." | 2.72 | Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjögren syndrome: a case report and literature review. ( Gunapala, A; Perera, S; Ranaweerage, R, 2021) |
| "Inherited classic Bartter syndrome (cBS) is an autosomal recessive renal tubular disorder resulting from inactivating mutations in the asolateral chloride channel (C1C-Kb) and usually presents in early infancy or childhood with mild to moderate hypokalemia." | 1.40 | Hypokalemic paralysis in a middle-aged female with classic Bartter syndrome. ( Chan, JS; Chiang, WF; Lin, SH, 2014) |
| "The complications to renal tubular acidosis such as hypokalemic muscle paralysis or chronic muscle weakness, nephrolithiasis, and osteomalacia can be avoided if the diagnosis of renal tubular acidosis is made and corrective alkali therapy is maintained." | 1.27 | Hypokalemic paralysis in Sjögren's syndrome secondary to renal tubular acidosis. ( Christensen, KS, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (84.62) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Ranaweerage, R | 1 |
| Perera, S | 1 |
| Gunapala, A | 1 |
| Chiang, WF | 1 |
| Lin, SH | 2 |
| Chan, JS | 1 |
| POSKANZER, DC | 1 |
| KERR, DN | 1 |
| RAVINA, A | 1 |
| RECORDIER, AM | 1 |
| SERRATRICE, G | 1 |
| VIGNOLI, R | 1 |
| KATO, E | 1 |
| OSAWA, S | 1 |
| WAKASUGI, A | 1 |
| KIRIU, Y | 1 |
| ATO, T | 1 |
| MITSUNO, K | 1 |
| ITAZU, Y | 1 |
| CARSON, MJ | 1 |
| PEARSON, CM | 2 |
| DE GRAEFF, J | 1 |
| LAMEIJER, LD | 1 |
| OKINAKA, S | 1 |
| OHSAWA, N | 1 |
| SHIZUME, K | 1 |
| MOTOHASHI, K | 1 |
| FUJITA, T | 1 |
| MURAKAWA, S | 1 |
| MATSUZAKI, F | 1 |
| MORII, H | 1 |
| UCHIKAWA, T | 1 |
| Yasue, H | 1 |
| Itoh, T | 1 |
| Mizuno, Y | 1 |
| Harada, E | 1 |
| Herman, E | 1 |
| Radó, J | 1 |
| Kijima, Y | 1 |
| Sasaoka, T | 1 |
| Udezue, EO | 1 |
| Harrold, BP | 1 |
| Gledhill, RF | 1 |
| Christensen, KS | 1 |
| Palmér, M | 1 |
| Wikström, B | 1 |
| Selye, H | 1 |
| Szabo, S | 1 |
| Mécs, I | 1 |
| Streeten, DH | 1 |
| Speller, PJ | 1 |
| Klaassen, CD | 1 |
| Kalbian, VV | 1 |
| Radó, JP | 2 |
| Marosi, J | 2 |
| Takó, J | 2 |
| Dévényi, I | 1 |
| Buck, SH | 1 |
| Lage, GL | 1 |
| Szende, L | 1 |
| Pereira, VG | 1 |
| Wajchenberg, BL | 1 |
| Quintão, ER | 1 |
| Stein, L | 1 |
| Shapiro, N | 1 |
| Stein, D | 1 |
1 review available for spironolactone and Palsy
| Article | Year |
|---|---|
Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjögren syndrome: a case report and literature review.
Topics: Diagnosis, Differential; Dietary Supplements; Gitelman Syndrome; Humans; Hypokalemia; Paralysis; Pot | 2021 |
25 other studies available for spironolactone and Palsy
| Article | Year |
|---|---|
Hypokalemic paralysis in a middle-aged female with classic Bartter syndrome.
Topics: Bartter Syndrome; Chloride Channels; Dietary Supplements; Diuretics; Female; Genetic Predisposition | 2014 |
Periodic paralysis with response to spironolactone.
Topics: Aldosterone; Diuretics; Humans; Mineralocorticoid Receptor Antagonists; Paralysis; Potassium; Spiron | 1961 |
[Spirolactone].
Topics: Edema; Humans; Myasthenia Gravis; Paralysis; Spironolactone | 1962 |
[TREATMENT BY SPIRONOLACTONE OF A FAMILIAL PERIODIC PARALYSIS WITH HYPERALDOSTERONISM].
Topics: Humans; Hyperaldosteronism; Paralyses, Familial Periodic; Paralysis; Spironolactone | 1963 |
[CLINICAL TRIALS OF THE NEW ALDOSTERONE ANTAGONISTS OF A STEROID NATURE].
Topics: Adolescent; Chronic Disease; Diabetes Mellitus; Extremities; Familial Mediterranean Fever; Geriatric | 1964 |
FAMILIAL HYPERKALEMIC PERIODIC PARALYSIS WITH MYOTONIC FEATURES.
Topics: 17-Ketosteroids; Acetazolamide; Adolescent; Biopsy; Blood Chemical Analysis; Child; Dextroamphetamin | 1964 |
THE PERIODIC PARALYSES: DIFFERENTIAL FEATURES AND PATHOLOGICAL OBSERVATIONS IN PERMANENT MYOPATHIC WEAKNESS.
Topics: Acetazolamide; Drug Therapy; Epinephrine; Humans; Hydrochlorothiazide; Hydrocortisone; Hyperkalemia; | 1964 |
PERIODIC PARALYSIS.
Topics: Adolescent; Chlorides; Cortisone; Diet Therapy; Diet, Sodium-Restricted; Digoxin; Drug Therapy; Gene | 1965 |
Effect of aldosterone antagonist (SC 9420) on periodic paralysis.
Topics: Aldosterone; Antihypertensive Agents; Diuretics; Humans; Mineralocorticoid Receptor Antagonists; Par | 1962 |
Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice.
Topics: Administration, Oral; Aged, 80 and over; Female; Glycyrrhiza; Humans; Hypertension; Hypokalemia; Inj | 2007 |
[Hyperkalemia with fatal paralysis in a diabetic patient treated with aldactone].
Topics: Adult; Diabetic Nephropathies; Humans; Hyperkalemia; Male; Paralysis; Spironolactone | 1967 |
[Hypokalemic paralysis in a case with hyperthyroidism and idiopathic hyperaldosteronism].
Topics: Female; Humans; Hyperaldosteronism; Hyperthyroidism; Hypokalemia; Middle Aged; Paralysis; Periodicit | 1983 |
Hyperkalaemic paralysis due to spironolactone.
Topics: Aged; Edema; Humans; Hyperkalemia; Male; Paralysis; Spironolactone | 1980 |
Secondary hyperkalaemic paralysis.
Topics: Humans; Hyperkalemia; Mineralocorticoid Receptor Antagonists; Paralysis; Renal Insufficiency; Spiron | 1998 |
Hypokalemic paralysis in Sjögren's syndrome secondary to renal tubular acidosis.
Topics: Acidosis, Renal Tubular; Bicarbonates; Female; Humans; Hypokalemia; Middle Aged; Paralysis; Potassiu | 1985 |
[Spironolactone-induced hyperkalemic paralysis in a patient with normal liver and kidney function].
Topics: Aged; Female; Humans; Hyperkalemia; Paralysis; Spironolactone | 1985 |
Protection by catatoxic steroids against the paralysis caused by combined treatment with thyroxine and methylphenidate.
Topics: Androstenols; Animals; Drug Synergism; Estradiol; Ethylestrenol; Female; Humans; Hydroxysteroids; Hy | 1972 |
The role of mineralocorticoids in the pathogenesis of hypokalemic periodic paralysis.
Topics: Adult; Aldosterone; Angiotensin II; Desoxycorticosterone; Humans; Hydrocortisone; Hyperaldosteronism | 1974 |
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.
Topics: Analysis of Variance; Animals; Bile; Biotransformation; Cardiac Glycosides; Digitoxin; Digoxin; Dose | 1974 |
Iatrogenic hyperkalemic paralysis with electrocardiographic changes.
Topics: Bicarbonates; Calcium; Electrocardiography; Furosemide; Gluconates; Glucose; Heart; Humans; Hyperkal | 1974 |
Hyperkalemic intermittent paralysis associated with spironolactone in a patient with cardiac cirrhosis.
Topics: Acetazolamide; Adult; Aldosterone; Ascites; Female; Furosemide; Heart Failure; Heart Valve Diseases; | 1968 |
Possible mechanism of the prevention of digitoxin toxicity by spironolactone in the mouse.
Topics: Animals; Digitoxin; Drug Antagonism; Enzyme Induction; Liver; Male; Mice; Paralysis; Pentobarbital; | 1971 |
Hyperkalemic changes during spironolactone therapy for cirrhosis and ascites, with special reference to hyperkalemic intermittent paralysis.
Topics: Ascites; Diuretics; Female; Humans; Hyperkalemia; Kidney Function Tests; Kidney Tubules; Liver Cirrh | 1968 |
Periodic paralysis associated with hyperthyroidism. Study of the precipitating factors.
Topics: Adult; Aldosterone; Familial Mediterranean Fever; Glucose Tolerance Test; Humans; Hyperthyroidism; I | 1968 |
Primary aldosteronism due to adrenocortical adenoma (Conn's syndrome).
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Female; Humans; Hyperaldosteronism; Hypokalemia; Paralysis; | 1966 |