spironolactone has been researched along with Nerve Degeneration in 2 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aldosterone was administered via an osmotic minipump that was implanted subcutaneously into the mid-scapular region." | 5.39 | Aldosterone: a mediator of retinal ganglion cell death and the potential role in the pathogenesis in normal-tension glaucoma. ( Fujita, T; Hirooka, K; Itano, T; Nakamura, T; Nishiyama, A; Nitta, E; Shiraga, F; Tenkumo, K, 2013) |
| "Aldosterone was administered via an osmotic minipump that was implanted subcutaneously into the mid-scapular region." | 1.39 | Aldosterone: a mediator of retinal ganglion cell death and the potential role in the pathogenesis in normal-tension glaucoma. ( Fujita, T; Hirooka, K; Itano, T; Nakamura, T; Nishiyama, A; Nitta, E; Shiraga, F; Tenkumo, K, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nitta, E | 1 |
| Hirooka, K | 1 |
| Tenkumo, K | 1 |
| Fujita, T | 1 |
| Nishiyama, A | 1 |
| Nakamura, T | 1 |
| Itano, T | 1 |
| Shiraga, F | 1 |
| Simopoulos, AP | 1 |
| Delea, CS | 1 |
| Bartter, FC | 1 |
2 other studies available for spironolactone and Nerve Degeneration
| Article | Year |
|---|---|
Aldosterone: a mediator of retinal ganglion cell death and the potential role in the pathogenesis in normal-tension glaucoma.
Topics: Aldosterone; Animals; Apoptosis; Cell Survival; Glaucoma; Intraocular Pressure; Male; Mineralocortic | 2013 |
Neurodegenerative disorders and hyperaldosteronism.
Topics: Adolescent; Aldosterone; Angiotensin II; Birth Weight; Blood Pressure; Body Weight; Bundle-Branch Bl | 1971 |