spironolactone has been researched along with Nephrocalcinosis in 5 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Nephrocalcinosis: A condition characterized by calcification of the renal tissue itself. It is usually seen in distal RENAL TUBULAR ACIDOSIS with calcium deposition in the DISTAL KIDNEY TUBULES and the surrounding interstitium. Nephrocalcinosis causes RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus, both the composition of the sulfur-containing radical and the steroid moiety are important for protection against inorganic mercury poisoning." | 7.66 | The protective effect of sulfur-containing steroids against nephrocalcinosis induced by mercuric chloride in rats. ( Gagnon, MJ; Szabo, S, 1983) |
| "The renal tubular necrosis and calcification as well as the mortality induced by mercuric chloride in the rat are readily prevented by prior treatment with well-tolerated amounts of spironolactone." | 7.65 | Mercury poisoning: prevention by spironolactone. ( Selye, H, 1970) |
| " Thus, both the composition of the sulfur-containing radical and the steroid moiety are important for protection against inorganic mercury poisoning." | 3.66 | The protective effect of sulfur-containing steroids against nephrocalcinosis induced by mercuric chloride in rats. ( Gagnon, MJ; Szabo, S, 1983) |
| "The renal tubular necrosis and calcification as well as the mortality induced by mercuric chloride in the rat are readily prevented by prior treatment with well-tolerated amounts of spironolactone." | 3.65 | Mercury poisoning: prevention by spironolactone. ( Selye, H, 1970) |
| "For the first time neonatal variant of Bartter syndrome to 14." | 2.42 | [Bartter syndrome and it's neonatal type]. ( Jakutovic, M; Jankauskiene, A, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jankauskiene, A | 1 |
| Jakutovic, M | 1 |
| Szabo, S | 1 |
| Gagnon, MJ | 1 |
| Atkinson, SA | 1 |
| Shah, JK | 1 |
| McGee, C | 1 |
| Steele, BT | 1 |
| Garg, BD | 1 |
| Solymoss, B | 1 |
| Tuchweber, B | 1 |
| Selye, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Calciuric Effect and Cyclic Parenteral Nutrition in Preterm Infants[NCT00711763] | 1 participants (Actual) | Observational | 2008-07-31 | Terminated (stopped due to failure to recruit more patients and lack of supporting personnel.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for spironolactone and Nephrocalcinosis
| Article | Year |
|---|---|
[Bartter syndrome and it's neonatal type].
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Bartter Syndrome; Bone Diseases, Metabolic; Cal | 2003 |
4 other studies available for spironolactone and Nephrocalcinosis
| Article | Year |
|---|---|
The protective effect of sulfur-containing steroids against nephrocalcinosis induced by mercuric chloride in rats.
Topics: Animals; Female; Mercuric Chloride; Mercury; Mercury Poisoning; Nephrocalcinosis; Rats; Rats, Inbred | 1983 |
Mineral excretion in premature infants receiving various diuretic therapies.
Topics: Birth Weight; Bone Diseases, Metabolic; Diuretics; Drug Therapy, Combination; Female; Furosemide; Hu | 1988 |
Effect of spironolactone on the distribution and excretion of 203-HgCl2 in the rat.
Topics: Animals; Chlorides; Feces; Female; Kidney; Liver; Lung; Mercury; Mercury Isotopes; Nephrocalcinosis; | 1971 |
Mercury poisoning: prevention by spironolactone.
Topics: Acute Kidney Injury; Animals; Chelating Agents; Dimercaprol; Female; Kidney Tubules; Mercury Poisoni | 1970 |