spironolactone has been researched along with Nephritis in 11 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Nephritis: Inflammation of any part of the KIDNEY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated the role of aldosterone as a mediator of renal inflammation and fibrosis in a rat model of aldosterone/salt hypertension using the selective aldosterone blocker, eplerenone." | 7.72 | Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. ( Blasi, ER; Blomme, EA; McMahon, EG; Polly, ML; Rocha, R; Rudolph, AE, 2003) |
| "Anti-GBM nephritis was induced in rats by the intravenous, injection of anti-GBM serum, and test drugs were administered 5 days after the induction of nephritis." | 5.33 | Effects of Saireito, a Japanese herbal medicine, on edema via antagonistic actions against aldosterone in anti-GBM nephritic rats. ( Hattori, T; Kase, Y; Maruyama, H; Nakai, Y; Nishimura, H; Sakakibara, I; Takeda, S, 2006) |
| "We evaluated the role of aldosterone as a mediator of renal inflammation and fibrosis in a rat model of aldosterone/salt hypertension using the selective aldosterone blocker, eplerenone." | 3.72 | Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. ( Blasi, ER; Blomme, EA; McMahon, EG; Polly, ML; Rocha, R; Rudolph, AE, 2003) |
| "The present study was made to clarify the mechanisms of the antinephritic action of SA-446, an angiotensin I converting enzyme inhibitor, on crescentic-type anti-GBM nephritis in rats as compared to the actions of spironolactone (an antialdosterone agent), kallidinogenase (a kallikrein agent) and saralasin (an angiotensin II antagonist)." | 3.67 | Studies on mechanisms of antinephritic action of SA-446 an angiotensin I converting enzyme inhibitor (1). A comparison with actions of spironolactone, kallidinogenase and saralasin. ( Ito, M; Saito, N; Suzuki, Y, 1986) |
| "Anti-GBM nephritis was induced in rats by the intravenous, injection of anti-GBM serum, and test drugs were administered 5 days after the induction of nephritis." | 1.33 | Effects of Saireito, a Japanese herbal medicine, on edema via antagonistic actions against aldosterone in anti-GBM nephritic rats. ( Hattori, T; Kase, Y; Maruyama, H; Nakai, Y; Nishimura, H; Sakakibara, I; Takeda, S, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mohamed, RH | 1 |
| Abdel-Aziz, HR | 1 |
| Abd El Motteleb, DM | 1 |
| Abd El-Aziz, TA | 1 |
| Schupp, N | 1 |
| Kolkhof, P | 1 |
| Queisser, N | 1 |
| Gärtner, S | 1 |
| Schmid, U | 1 |
| Kretschmer, A | 1 |
| Hartmann, E | 1 |
| Oli, RG | 1 |
| Schäfer, S | 1 |
| Stopper, H | 1 |
| Blasi, ER | 1 |
| Rocha, R | 1 |
| Rudolph, AE | 1 |
| Blomme, EA | 1 |
| Polly, ML | 1 |
| McMahon, EG | 1 |
| DELVAGLIO, B | 1 |
| Hattori, T | 1 |
| Maruyama, H | 1 |
| Nishimura, H | 1 |
| Nakai, Y | 1 |
| Sakakibara, I | 1 |
| Kase, Y | 1 |
| Takeda, S | 1 |
| Nagase, M | 1 |
| Shibata, S | 1 |
| Yoshida, S | 1 |
| Nagase, T | 1 |
| Gotoda, T | 1 |
| Fujita, T | 1 |
| Suzuki, Y | 2 |
| Ito, M | 1 |
| Saito, N | 1 |
| Ina, K | 1 |
| Yamagami, I | 1 |
| Cannon, PJ | 1 |
| Leeming, JM | 1 |
| Sommers, SC | 1 |
| Winters, RW | 1 |
| Laragh, JH | 1 |
| Nagasaka, M | 1 |
| Nakamura, K | 1 |
| Kinouchi, T | 1 |
| Kurosawa, T | 1 |
| Ito, T | 1 |
| Shul'ga, IuD | 1 |
| Kondratskaia, LV | 1 |
1 review available for spironolactone and Nephritis
| Article | Year |
|---|---|
Juxtaglomerular cell hyperplasia and secondary hyperaldosteronism (Bartter's syndrome): a re-evaluation of the pathophysiology.
Topics: Acid-Base Equilibrium; Adolescent; Adult; Aldosterone; Child; Child, Preschool; Female; Humans; Hype | 1968 |
10 other studies available for spironolactone and Nephritis
| Article | Year |
|---|---|
Effect of RAS inhibition on TGF-β, renal function and structure in experimentally induced diabetic hypertensive nephropathy rats.
Topics: Animals; Drug Therapy, Combination; Hypertension, Renal; Kidney; Kidney Function Tests; Male; Nephri | 2013 |
Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats.
Topics: Animals; Apoptosis; Blood Pressure; Cell Division; Desoxycorticosterone; Disease Models, Animal; DNA | 2011 |
Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats.
Topics: Aldosterone; Animals; Blood Pressure; Cytokines; Eplerenone; Fibrosis; Hypertension, Renal; Immunohi | 2003 |
[EDEMAS AND SPIRONOLACTONES].
Topics: Edema; Female; Glomerulonephritis; Humans; Nephritis; Pregnancy; Pregnancy Complications; Premenstru | 1964 |
Effects of Saireito, a Japanese herbal medicine, on edema via antagonistic actions against aldosterone in anti-GBM nephritic rats.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroi | 2006 |
Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker.
Topics: Animals; Apoptosis; Biomarkers; Blood Pressure; Eplerenone; Fibrosis; Glomerulosclerosis, Focal Segm | 2006 |
Studies on mechanisms of antinephritic action of SA-446 an angiotensin I converting enzyme inhibitor (1). A comparison with actions of spironolactone, kallidinogenase and saralasin.
Topics: 3-Mercaptopropionic Acid; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pres | 1986 |
[Pharmacological studies on diuretics. 6. Actions of various diuretics on experimental nephrotic rats].
Topics: Acetazolamide; Aminophylline; Animals; Diuresis; Diuretics; Ethacrynic Acid; Furosemide; Glycosides; | 1973 |
The effects of aldosterone and spirolactone on renal sodium and potassium excretion during mannitol diuresis.
Topics: Aldosterone; Alkalies; Animals; Chronic Disease; Diuresis; Dogs; Female; Humans; Injections, Intrave | 1968 |
[Use of aldactone in hypertension and nephritis].
Topics: Humans; Hypertension; Hypertension, Renal; Nephritis; Spironolactone | 1971 |