Compounds > spironolactone
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spironolactone and Myasthenia Gravis

spironolactone has been researched along with Myasthenia Gravis in 31 studies

Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Myasthenia Gravis: A disorder of neuromuscular transmission characterized by fatigable weakness of cranial and skeletal muscles with elevated titers of ACETYLCHOLINE RECEPTORS or muscle-specific receptor tyrosine kinase (MuSK) autoantibodies. Clinical manifestations may include ocular muscle weakness (fluctuating, asymmetric, external ophthalmoplegia; diplopia; ptosis; and weakness of eye closure) and extraocular fatigable weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles (ocular myasthenia). THYMOMA is commonly associated with this condition.

Research Excerpts

ExcerptRelevanceReference
"Our study confirms pregnancy is more difficult to manage at the beginning of MG."1.33[Myasthenia gravis and pregnancy: clinical course and management of delivery and the postpartum phase]. ( de Seze, J; Defebvre, L; Delalande, S; Delrieu, O; Destée, A; Fourrier, F; Leys, D; Ramirez, C; Stojkovic, T; Vermersch, P, 2006)
"The diagnosis of myasthenia gravis is often difficult and calls for a broader use of pharmacological and electrodiagnostic tests."1.24MYASTHENIA GRAVIS: MEDICAL ASPECTS. ( BUCKLER, WS; ZELDOWICZ, LR, 1965)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199030 (96.77)18.7374
1990's0 (0.00)18.2507
2000's1 (3.23)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
GOTTLIEB, B1
LAURENT, LP1
RAVINA, A1
FARDEAU, M1
SATOYOSHI, E1
MURAKAMI, K1
OKAZAKI, T1
COSSA, P1
MAMOU, H1
MORGENSTEIN, S1
LAPRESLE, J1
BOUDIN, G1
GOULON, M3
HAMBURGER, J1
LHERMITTE, F1
PEQUIGNOT, H1
LEFEVRE, JP1
FERRARI, G1
VIO, M1
ZELDOWICZ, LR1
BUCKLER, WS1
JEUNE, M1
VINCENT, P1
HUMBERT, G1
LEVRAT, R1
PIETTE, Y1
VERHELST, S1
PLAUCHU, M1
DALMAIS, J1
BUSSY, L1
TETE, R1
MOULINIER, B1
Ramirez, C1
de Seze, J1
Delrieu, O1
Stojkovic, T1
Delalande, S1
Fourrier, F1
Leys, D1
Defebvre, L1
Destée, A1
Vermersch, P1
Lincke, HO1
Yamada, S1
Ishii, Y1
Noguchi, H1
Ohara, H1
Brun, J1
Magnin, F1
von Reis, G2
Liljestrand, A2
Matell, G2
Oosterhuis, HJ2
Takahashi, A1
Henriquet, F1
Balestra, L1
Barois, A2
Gajdos, P1
Grosbuis, S2
Joron, MH2
Bennaiche, M1
Nouailhat, F1
van der Slooten, EP1
Gościńska, Z1
Kusiak-Dadak, M1
Miezyński, W1
Petryk, O1
Rokosz, A1
Nakamoto, M1
Sepe, O1
Stöber, G1
Poppe, W1
Sassi, D1

Reviews

1 review available for spironolactone and Myasthenia Gravis

ArticleYear
[ACTH or adrenocortical hormone therapy in myasthenia gravis, myotonia and herpes zoster].
    Horumon to rinsho. Clinical endocrinology, 1968, Volume: 16, Issue:3

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Herpes Zoster; Humans; Myasthenia Gravis; Myot

1968

Trials

1 trial available for spironolactone and Myasthenia Gravis

ArticleYear
[Evaluation of the effect of spinonolactone on myasthenia gravis using a double blind test].
    Naika. Internal medicine, 1967, Volume: 19, Issue:4

    Topics: Adult; Cholinesterase Inhibitors; Female; Humans; Myasthenia Gravis; Placebos; Spironolactone

1967

Other Studies

29 other studies available for spironolactone and Myasthenia Gravis

ArticleYear
Spironolactone in the treatment of myasthenia gravis.
    Lancet (London, England), 1961, Sep-02, Volume: 2, Issue:7201

    Topics: Aldosterone; Diuretics; Humans; Mineralocorticoid Receptor Antagonists; Myasthenia Gravis; Spironola

1961
[Spirolactone].
    L' Annee therapeutique, 1962, Volume: 33

    Topics: Edema; Humans; Myasthenia Gravis; Paralysis; Spironolactone

1962
[MYASTHENIA].
    La Revue du praticien, 1964, Feb-11, Volume: 14

    Topics: Ammonium Compounds; Blood; Cardiovascular Agents; Child; Diagnosis; Endocrinology; Ephedrine; Guanid

1964
[EFFECT OF TRIAMTERENE ON MYASTHENIA GRAVIS].
    Naika. Internal medicine, 1964, Volume: 13

    Topics: Diuretics; Drug Therapy; Ions; Myasthenia Gravis; Pharmacology; Potassium; Pterins; Sodium; Sodium,

1964
[TREATMENT OF NEUROMUSCULAR SYNDROMES WITH SPIROLACTONES].
    Gazette medicale de France, 1964, Sep-10, Volume: 71

    Topics: Familial Mediterranean Fever; Humans; Myasthenia Gravis; Spironolactone; Syndrome; Toxicology

1964
[MYASTHENIA AND SPIROLACTONE].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1964, Oct-26, Volume: 40

    Topics: Blood Chemical Analysis; Calcium; Calcium, Dietary; Chlorides; Cholinesterase Inhibitors; Deglutitio

1964
[HOW TO TREAT MYASTHENIA].
    La Presse medicale, 1964, Oct-10, Volume: 72

    Topics: Ambenonium Chloride; Ephedrine; Humans; Muscle Weakness; Myasthenia Gravis; Neostigmine; Physostigmi

1964
[PRACTICAL TREATMENT OF MYASTHENIA].
    Le Progres medical, 1964, Dec-10, Volume: 92

    Topics: Adrenal Cortex Hormones; Cholinesterase Inhibitors; Drug Therapy; Humans; Muscle Weakness; Myastheni

1964
[MYASTHENIA GRAVIS].
    Belgisch tijdschrift voor geneeskunde, 1965, Jan-15, Volume: 21

    Topics: Ambenonium Chloride; Atropine; Diagnosis; Drug Therapy; Humans; Myasthenia Gravis; Neostigmine; Pral

1965
[5 CASES OF MYASTHENIA TREATED WITH SPIRONOLACTONE (SC9420 LEPETIT)].
    Giornale di psichiatria e di neuropatologia, 1964, Volume: 92

    Topics: Humans; Muscle Weakness; Myasthenia Gravis; Spironolactone

1964
MYASTHENIA GRAVIS: MEDICAL ASPECTS.
    Canadian Medical Association journal, 1965, Jul-31, Volume: 93

    Topics: Acetylcholine; Botulism; Bromides; Cholinesterase Inhibitors; Decamethonium Compounds; Diagnosis; Di

1965
[Preliminary note on the use of a spirolactone in the treatment of myasthenia].
    Lyon medical, 1962, May-27, Volume: 94

    Topics: Aldosterone; Humans; Mineralocorticoid Receptor Antagonists; Muscle Weakness; Myasthenia Gravis; Spi

1962
[Myasthenia gravis and spironolactone].
    Acta neurologica et psychiatrica Belgica, 1962, Volume: 62

    Topics: Aldosterone; Humans; Mineralocorticoid Receptor Antagonists; Myasthenia Gravis; Progesterone; Spiron

1962
[Apropos of a case of myasthenia gravis improved by spirolactones].
    Lyon medical, 1962, May-27, Volume: 94

    Topics: Aldosterone; Humans; Mineralocorticoid Receptor Antagonists; Myasthenia Gravis; Spironolactone

1962
[Myasthenia gravis and pregnancy: clinical course and management of delivery and the postpartum phase].
    Revue neurologique, 2006, Volume: 162, Issue:3

    Topics: Abortion, Therapeutic; Adult; Autoantibodies; Autoantigens; Cholinesterase Inhibitors; Delivery, Obs

2006
[Treatment of myasthenia with the aldosterone antagonist spironolactone].
    Munchener medizinische Wochenschrift (1950), 1966, Feb-04, Volume: 108, Issue:5

    Topics: Cholinesterase Inhibitors; Female; Humans; Hyperkalemia; Middle Aged; Mineralocorticoid Receptor Ant

1966
[Transient and curable myasthenia appearing 3 years after lower right thymectomy].
    Le Poumon et le coeur, 1977, Volume: 33, Issue:2

    Topics: Female; Humans; Middle Aged; Myasthenia Gravis; Neostigmine; Postoperative Complications; Pyridostig

1977
Results with ACTH and spironolactone in severe cases of myasthenia gravis.
    Acta neurologica Scandinavica. Supplementum, 1965, Volume: 13 Pt 2

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Female; Humans; Intensive Care Units; Male; Mi

1965
Treatment of severe myasthenia gravis with large doses of ACTH.
    Annals of the New York Academy of Sciences, 1966, Jan-26, Volume: 135, Issue:1

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Cholinesterase Inhibitors; Female; Humans; Mal

1966
[On motor end-plate diseases with special reference to myasthenia gravis].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1965, Volume: 71

    Topics: Acetylcholine; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Antigen-Antibody React

1965
[On the therapy of myasthenia gravis. (Presentation of a case)].
    Minerva anestesiologica, 1970, Volume: 36, Issue:4

    Topics: Adrenocorticotropic Hormone; Adult; Autoantibodies; Autoimmune Diseases; Female; Humans; Myasthenia

1970
[Treatment of myasthenia with corticotropic hormones].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1972, Dec-14, Volume: 48, Issue:51

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Delayed-Action Preparations; Female; Hu

1972
[Treatment of myasthenia with adrencorticotrophins (ACTH and Synacthen). Apropos of 100 treatments in 25 patients].
    Revue neurologique, 1972, Volume: 127, Issue:4

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Cholinesterase Inhibitors; Evaluation Studies

1972
The effect of aldactone-A on intracellular potassium in patients with myasthenia gravis.
    Journal of the neurological sciences, 1973, Volume: 19, Issue:4

    Topics: Adult; Body Water; Cholinesterase Inhibitors; Evaluation Studies as Topic; Female; Humans; Male; Mid

1973
[Treatment of myasthenia gravis in children].
    Pediatria polska, 1972, Volume: 47, Issue:4

    Topics: Adolescent; Age Factors; Child; Female; Humans; Myasthenia Gravis; Neostigmine; Spironolactone; Thym

1972
[Clinical studies on the urinary excretion of aldosterone in myasthenia gravis].
    Nihon Naibunpi Gakkai zasshi, 1967, Nov-20, Volume: 43, Issue:8

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adult; Aldosterone; Ambenonium Chloride; Cat

1967
[Treatment of myasthenia with spironolactone].
    Minerva medica, 1969, Jul-21, Volume: 60, Issue:57

    Topics: Adult; Female; Humans; Middle Aged; Myasthenia Gravis; Spironolactone

1969
[On the diagnosis and therapy of myasthenia gravis pseudoparalytica].
    Zeitschrift fur arztliche Fortbildung, 1969, May-15, Volume: 63, Issue:10

    Topics: Diagnosis, Differential; Female; Humans; Middle Aged; Myasthenia Gravis; Physostigmine; Spironolacto

1969
[Use of spirolactone in treatment of myasthenia in pregnancy].
    Quaderni di clinica ostetrica e ginecologica, 1965, Volume: 20, Issue:2

    Topics: Female; Humans; Myasthenia Gravis; Pregnancy; Pregnancy Complications; Spironolactone

1965