spironolactone has been researched along with Muscular Dystrophy in 3 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Combined treatment with the ACEi lisinopril and the nonspecific MR antagonist spironolactone surprisingly improves skeletal muscle, in addition to heart function and pathology in a Duchenne muscular dystrophy (DMD) mouse model." | 3.85 | Renin-angiotensin-aldosterone system inhibitors improve membrane stability and change gene-expression profiles in dystrophic skeletal muscles. ( Bhattacharya, S; Chadwick, JA; Lowe, J; Rafael-Fortney, JA; Weisleder, N, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chadwick, JA | 1 |
| Bhattacharya, S | 1 |
| Lowe, J | 1 |
| Weisleder, N | 1 |
| Rafael-Fortney, JA | 1 |
| PEARSON, CM | 1 |
| Nielsen, H | 1 |
| Landbo, K | 1 |
3 other studies available for spironolactone and Muscular Dystrophy
| Article | Year |
|---|---|
Renin-angiotensin-aldosterone system inhibitors improve membrane stability and change gene-expression profiles in dystrophic skeletal muscles.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cell Membrane; Dose-Response Relationship, Drug; | 2017 |
THE PERIODIC PARALYSES: DIFFERENTIAL FEATURES AND PATHOLOGICAL OBSERVATIONS IN PERMANENT MYOPATHIC WEAKNESS.
Topics: Acetazolamide; Drug Therapy; Epinephrine; Humans; Hydrochlorothiazide; Hydrocortisone; Hyperkalemia; | 1964 |
[Hypokalemia, myopathy with myoglobinuria after prolonged ingestion of licorice].
Topics: Adult; Alkalosis; Glycyrrhiza; Humans; Hypokalemia; Male; Muscular Dystrophies; Myoglobinuria; Plant | 1970 |