spironolactone has been researched along with Metastase in 14 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osimertinib is a tyrosine kinase approved and effective in treating lung adenocarcinomas that have one of several common activating mutations in epidermal growth factor receptor." | 6.72 | OPALS: A New Osimertinib Adjunctive Treatment of Lung Adenocarcinoma or Glioblastoma Using Five Repurposed Drugs. ( Halatsch, ME; Kast, RE; Rosell, R, 2021) |
| "Osimertinib is a tyrosine kinase approved and effective in treating lung adenocarcinomas that have one of several common activating mutations in epidermal growth factor receptor." | 2.72 | OPALS: A New Osimertinib Adjunctive Treatment of Lung Adenocarcinoma or Glioblastoma Using Five Repurposed Drugs. ( Halatsch, ME; Kast, RE; Rosell, R, 2021) |
| "Eplerenone is a nonsteroidal mineralocorticoid antagonist demonstrated to abrogate mineralocorticoid excess." | 1.46 | Efficacy of Eplerenone in the Management of Mineralocorticoid Excess in Men With Metastatic Castration-resistant Prostate Cancer Treated With Abiraterone Without Prednisone. ( Agarwal, N; Alex, A; Bailey, E; Batten, J; Boucher, K; Gaston, D; Gill, D; Gupta, S; Hahn, A; Stenehjem, D, 2017) |
| "Treatment with spironolactone, mitotane, or aminoglutethimide had transient clinical effects." | 1.27 | Aldosterone-producing adrenocortical carcinoma. Preoperative recognition and course in three cases. ( Arteaga, E; Biglieri, EG; Kater, CE; Lopez, JM; Schambelan, M, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (64.29) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Kast, RE | 1 |
| Halatsch, ME | 1 |
| Rosell, R | 1 |
| Feldman, RD | 1 |
| Ding, Q | 1 |
| Hussain, Y | 1 |
| Limbird, LE | 1 |
| Pickering, JG | 1 |
| Gros, R | 1 |
| Flynn, T | 1 |
| Guancial, EA | 1 |
| Kilari, M | 1 |
| Kilari, D | 1 |
| Gill, D | 1 |
| Gaston, D | 1 |
| Bailey, E | 1 |
| Hahn, A | 1 |
| Gupta, S | 1 |
| Batten, J | 1 |
| Alex, A | 1 |
| Boucher, K | 1 |
| Stenehjem, D | 1 |
| Agarwal, N | 1 |
| GEOKAS, MC | 1 |
| CHUN, JY | 1 |
| DINAN, JJ | 1 |
| BECK, IT | 1 |
| CRANE, MG | 1 |
| HARRIS, JJ | 1 |
| HERBER, R | 1 |
| Arteaga, E | 1 |
| Biglieri, EG | 1 |
| Kater, CE | 1 |
| Lopez, JM | 1 |
| Schambelan, M | 1 |
| Bare, RL | 1 |
| Torti, FM | 1 |
| Walsh, PC | 1 |
| Siiteri, PK | 1 |
| Moertel, CG | 1 |
| Engstrom, P | 1 |
| Lavin, PT | 1 |
| Gelber, RD | 1 |
| Carbone, PP | 1 |
| Stephens, RL | 1 |
| Hoogstraten, B | 1 |
| Haas, C | 1 |
| Clark, G | 1 |
| Taylor, SG | 1 |
| Newmark, SR | 1 |
| Dluhy, RG | 1 |
| Bennett, AH | 1 |
| Waddell, WR | 1 |
2 reviews available for spironolactone and Metastase
| Article | Year |
|---|---|
OPALS: A New Osimertinib Adjunctive Treatment of Lung Adenocarcinoma or Glioblastoma Using Five Repurposed Drugs.
Topics: Acrylamides; Adenocarcinoma of Lung; Aniline Compounds; Animals; Azithromycin; Carcinoma, Non-Small- | 2021 |
Endocrine therapy of prostate cancer.
Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Aminoglutethimide; Androgen Antagonists; Antineoplasti | 1998 |
2 trials available for spironolactone and Metastase
| Article | Year |
|---|---|
Chemotherapy of gastric and pancreatic carcinoma: a controlled evaluation of combinations of 5-fluorouracil with nitrosoureas and "lactones".
Topics: Adenocarcinoma; Antineoplastic Agents; Drug Therapy, Combination; Fluorouracil; Humans; Lomustine; N | 1979 |
Pancreatic cancer treated with carmustine, fluorouracil, and spironolactone: a randomized study.
Topics: Adult; Carmustine; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Neopl | 1978 |
10 other studies available for spironolactone and Metastase
| Article | Year |
|---|---|
Aldosterone mediates metastatic spread of renal cancer via the G protein-coupled estrogen receptor (GPER).
Topics: Aldosterone; Animals; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Kid | 2016 |
Case Report: Spironolactone Withdrawal Associated With a Dramatic Response in a Patient With Metastatic Castrate-Resistant Prostate Cancer.
Topics: Abiraterone Acetate; Benzamides; Drug Antagonism; Humans; Male; Middle Aged; Neoplasm Metastasis; Ni | 2017 |
Efficacy of Eplerenone in the Management of Mineralocorticoid Excess in Men With Metastatic Castration-resistant Prostate Cancer Treated With Abiraterone Without Prednisone.
Topics: Abiraterone Acetate; Aged; Antineoplastic Combined Chemotherapy Protocols; Eplerenone; Humans; Male; | 2017 |
ISLET-CELL CARCINOMA (ZOLLINGER-ELLISON SYNDROME) WITH FULMINATING ADRENOCORTICAL HYPERFUNCTION AND HYPOKALEMIA.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenoma, Islet Cell; Adrenalectomy; Adrenocortical Hyper | 1965 |
PRIMARY ALDOSTERONISM DUE TO AN ADRENAL CARCINOMA.
Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Alkalosis; Blood; Drug Therapy; Hyperaldosteronism | 1965 |
Aldosterone-producing adrenocortical carcinoma. Preoperative recognition and course in three cases.
Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Female; Glucocortico | 1984 |
Suppression of plasma androgens by spironolactone in castrated men with carcinoma of the prostate.
Topics: Aged; Androgens; Androstenedione; Castration; Dehydroepiandrosterone; Depression, Chemical; Humans; | 1975 |
Common medical problems in disseminated cancer.
Topics: Androgens; Brain Neoplasms; Chlorothiazide; Dactinomycin; Estrogens; Humans; Hypercalcemia; Lymphede | 1970 |
Ectopic adrenocorticotropin syndrome with prostatic carcinoma.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adenocarcinoma; Adrenocorticotropic Hormone; Blood Gluco | 1973 |
Chemotherapy for carcinoma of the pancreas.
Topics: Adult; Aged; Autopsy; Biopsy; Carcinoma; Female; Fluorouracil; Humans; Laparotomy; Male; Middle Aged | 1973 |