spironolactone has been researched along with Mercury Poisoning in 10 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Mercury Poisoning: Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of MERCURY or MERCURY COMPOUNDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus, both the composition of the sulfur-containing radical and the steroid moiety are important for protection against inorganic mercury poisoning." | 7.66 | The protective effect of sulfur-containing steroids against nephrocalcinosis induced by mercuric chloride in rats. ( Gagnon, MJ; Szabo, S, 1983) |
| "The renal tubular necrosis and calcification as well as the mortality induced by mercuric chloride in the rat are readily prevented by prior treatment with well-tolerated amounts of spironolactone." | 7.65 | Mercury poisoning: prevention by spironolactone. ( Selye, H, 1970) |
| " Thus, both the composition of the sulfur-containing radical and the steroid moiety are important for protection against inorganic mercury poisoning." | 3.66 | The protective effect of sulfur-containing steroids against nephrocalcinosis induced by mercuric chloride in rats. ( Gagnon, MJ; Szabo, S, 1983) |
| "The renal tubular necrosis and calcification as well as the mortality induced by mercuric chloride in the rat are readily prevented by prior treatment with well-tolerated amounts of spironolactone." | 3.65 | Mercury poisoning: prevention by spironolactone. ( Selye, H, 1970) |
| "Spironolactone was given 30 min after the toxic agent." | 1.28 | Interaction of spironolactone with mercury. A possible molecular mechanism. ( Kourounakis, PN; Pouskoulelis, GP; Rekka, E, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (90.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Szabo, S | 1 |
| Gagnon, MJ | 1 |
| Cikrt, M | 1 |
| Lenger, V | 1 |
| Takahashi, H | 1 |
| Shibuya, Y | 1 |
| Kourounakis, PN | 1 |
| Pouskoulelis, GP | 1 |
| Rekka, E | 1 |
| Khandelwal, S | 1 |
| Kachru, DN | 1 |
| Tandon, SK | 1 |
| Lehotzky, K | 1 |
| Haddow, JE | 2 |
| Fish, CA | 1 |
| Marshall, PC | 1 |
| Lester, R | 1 |
| Eybl, V | 1 |
| Sýkora, J | 1 |
| Koutenská, M | 1 |
| Koutenský, J | 1 |
| Mertl, F | 1 |
| Marshall, P | 1 |
| Selye, H | 1 |
10 other studies available for spironolactone and Mercury Poisoning
| Article | Year |
|---|---|
The protective effect of sulfur-containing steroids against nephrocalcinosis induced by mercuric chloride in rats.
Topics: Animals; Female; Mercuric Chloride; Mercury; Mercury Poisoning; Nephrocalcinosis; Rats; Rats, Inbred | 1983 |
Distribution and excretion of 203Hg2+ in rats after unitiol, spironolactone and polythiol resin treatment.
Topics: Animals; Dimercaprol; Drug Combinations; Female; Mercury; Mercury Poisoning; Rats; Resins, Synthetic | 1980 |
Preventive mechanism of spironolactone against mercury-induced renal damage: role of metallothionein.
Topics: Animals; Kidney; Kidney Diseases; Male; Mercury; Mercury Poisoning; Metalloproteins; Metallothionein | 1979 |
Interaction of spironolactone with mercury. A possible molecular mechanism.
Topics: Animals; Canrenone; Feces; Female; Mercury; Mercury Poisoning; Rats; Rats, Sprague-Dawley; Spironola | 1992 |
Chelation in metal intoxication. XXVIII: Effect of thiochelators on mercury (II) toxicity: pre- and post treatment.
Topics: Acetylcysteine; Acrylates; Animals; Chelating Agents; Male; Mercury; Mercury Poisoning; Mercury Radi | 1988 |
Protection by spironolactone and different antidotes against acute organic mercury poisoning of rats.
Topics: Animals; Ethylmercuric Chloride; Male; Mercury Poisoning; Methanol; Organometallic Compounds; Penici | 1974 |
Biliary excretion of mercury enhanced by spironolactone.
Topics: Animals; Bile; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocytes; Kidney; Liver | 1972 |
Effect of spironolactone, thiomestrone and dimercaprol on the toxicity, retention and distribution of mercury in the mouse.
Topics: Androstenes; Androstenols; Animals; Antidotes; Brain; Digestive System; Dimercaprol; Drug Antagonism | 1973 |
Increased stool mercury excretion in the rat: the effect of spironolactone.
Topics: Adrenal Glands; Adrenalectomy; Animals; Brain Chemistry; Digestive System; Feces; Injections, Intrav | 1972 |
Mercury poisoning: prevention by spironolactone.
Topics: Acute Kidney Injury; Animals; Chelating Agents; Dimercaprol; Female; Kidney Tubules; Mercury Poisoni | 1970 |