spironolactone has been researched along with Lupus Nephritis in 3 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Lupus Nephritis: Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).
| Excerpt | Relevance | Reference |
|---|---|---|
| "These features were consistent with the Gitelman syndrome." | 1.56 | Systemic lupus erythematosus complicated by a Gitelman-like syndrome in an 8-year-old girl. ( Barathidasan, GS; Dhandapany, G; Ganesh, RN; Karunakar, P; Krishnamurthy, S; Rajendran, R; Ramamoorthy, JG; Ramya, K, 2020) |
| "Spironolactone-treated mice exhibited decreased histopathologic evidence of inflammation and tissue damage, as compared with control mice." | 1.35 | The role of aldosterone blockade in murine lupus nephritis. ( Anderson, MR; Bradke, A; Kaplan, MJ; Killen, PD; Monrad, SU, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Barathidasan, GS | 1 |
| Krishnamurthy, S | 1 |
| Karunakar, P | 1 |
| Rajendran, R | 1 |
| Ramya, K | 1 |
| Dhandapany, G | 1 |
| Ramamoorthy, JG | 1 |
| Ganesh, RN | 1 |
| SMITH, FG | 1 |
| LITMAN, N | 1 |
| LATTA, H | 1 |
| Monrad, SU | 1 |
| Killen, PD | 1 |
| Anderson, MR | 1 |
| Bradke, A | 1 |
| Kaplan, MJ | 1 |
3 other studies available for spironolactone and Lupus Nephritis
| Article | Year |
|---|---|
Systemic lupus erythematosus complicated by a Gitelman-like syndrome in an 8-year-old girl.
Topics: Alkalosis; Child; Cyclophosphamide; Drug Therapy, Combination; Female; Gitelman Syndrome; Humans; Hy | 2020 |
LUPUS GLOMERULONEPHRITIS. THE EFFECT OF LARGE DOSES OF CORTICOSTEROIDS ON RENAL FUNCTION AND RENAL LESIONS IN TWO CHILDREN.
Topics: Adolescent; Adrenal Cortex Hormones; Cortisone; Drug Therapy; Glomerulonephritis; Guanethidine; Hydr | 1965 |
The role of aldosterone blockade in murine lupus nephritis.
Topics: Animals; Antigen-Antibody Complex; Autoantibodies; Disease Progression; Female; Gene Expression; Kid | 2008 |