spironolactone has been researched along with Lung Diseases in 8 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Lung Diseases: Pathological processes involving any part of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Under this point of view and in connection with it the conception to apply cortisone in a combination as low as possible or even to avoid it al all, aldactone has been applied by way of trial in the therapy of the sarcoidosis of the lungs." | 3.65 | [Aldactone in the treatment of sarcoidosis of the lungs (author's transl)]. ( Wandelt-Freerksen, E, 1977) |
| " Patient demographic information was collected, as well as dosing regimens, use of other medications, and potassium concentrations." | 1.33 | Clinical experience with spironolactone in pediatrics. ( Buck, ML, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Ramalho, SHR | 1 |
| Claggett, BL | 1 |
| Sweitzer, NK | 1 |
| Fang, JC | 1 |
| Shah, SJ | 1 |
| Anand, IS | 1 |
| Pitt, B | 1 |
| Lewis, EF | 1 |
| Pfeffer, MA | 1 |
| Solomon, SD | 1 |
| Shah, AM | 1 |
| Segar, JL | 1 |
| Buck, ML | 1 |
| Wandelt-Freerksen, E | 1 |
| Komarov, FI | 1 |
| Daniliak, IG | 1 |
| Tuzel'baev, NK | 1 |
| Schauer, J | 1 |
| Urbaszek, W | 1 |
| Hahn, S | 1 |
| Günther, K | 1 |
| Lazar, G | 1 |
| Szabo, S | 1 |
| Husztik, E | 1 |
| Seassaro, E | 1 |
| Pellegrini, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Determining the Effect of Spironolactone on Electrolyte Supplementation in Preterm Infants With Chronic Lung Disease[NCT01721655] | Phase 2/Phase 3 | 40 participants (Anticipated) | Interventional | 2012-10-31 | Recruiting | ||
| A Retrospective Chart Review Evaluating the Impact of Steroid, Diuretic, and Fluid Use Practice Trends in Extreme Premature Infants at Risk for Bronchopulmonary Dysplasia (BPD) at a Single Center Neonatal Intensive Care Unit[NCT04971694] | 175 participants (Anticipated) | Observational | 2021-09-08 | Recruiting | |||
| A Randomized Open Label Trial of Spironolactone Versus Prednisolone in Corticosteroid-naïve Boys With DMD[NCT03777319] | Phase 1 | 2 participants (Actual) | Interventional | 2018-12-05 | Terminated (stopped due to Inability to recruit participants.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The determination of whether spironolactone has similar efficacy to glucocorticoids in improving muscle strength in steroid naïve DMD patients. This will be determined by measuring the time to complete a 100 meter timed test (100M). (NCT03777319)
Timeframe: 6 months
| Intervention | sec (Number) |
|---|---|
| Spironolactone | -0.6 |
| Prednisolone | -5.3 |
Secondary outcome measures will be Dynamometry score, which is a summation of maximum voluntary isometric contraction test values for knee flexion, knee extension, elbow flexion, and elbow extension (NCT03777319)
Timeframe: 6 months
| Intervention | kg (Number) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Elbow Flexion (Right)-Baseline | Elbow Flexion (Left)-Baseline | Elbow Extension (Right)-Baseline | Elbow Extension (Left)-Baseline | Knee Flexion (Right)-Baseline | Knee Flexion (Left)-Baseline | Knee Extension (Right)-Baseline | Knee Extension (Left)-Baseline | Elbow Flexion (Right)-Month 6 | Elbow Flexion (Left)-Month 6 | Elbow Extension (Right)-Month 6 | Elbow Extension (Left)-Month 6 | Knee Flexion (Right)-Month 6 | Knee Flexion (Left)-Month 6 | Knee Extension (Right)-Month 6 | Knee Extension (Left)-Month 6 | |
| Prednisolone | 3.6 | 4.1 | 5.3 | 4.1 | 3.3 | 3.4 | 4.8 | 5.2 | 2.9 | 3.4 | 4.3 | 3.8 | 4.1 | 3.9 | 6 | 5.1 |
| Spironolactone | 0 | 0 | 0 | 0 | 4.1 | 2.8 | 3.8 | 5.9 | 3.1 | 3.5 | 2.4 | 2.5 | 4.3 | 4.1 | 7.2 | 8.3 |
Electrolytes (Sodium, Potassium, Cloride and Carbon dioxide, mmol/L) will be measured on a monthly basis following initiation of either spironolactone or prednisolone. (NCT03777319)
Timeframe: 6 months
| Intervention | mmol/L (Number) | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sodium-Baseline | Sodium-Month 1 | Sodium-Month 2 | Sodium-Month 3 | Sodium-Month 4 | Sodium-Month 5 | Sodium-Month 6 | Potassium-Baseline | Potassium-Month 1 | Potassium-Month 2 | Potassium-Month 3 | Potassium-Month 4 | Potassium-Month 5 | Potassium-Month 6 | Chloride-Baseline | Chloride-Month 1 | Chloride-Month 2 | Chloride-Month 3 | Chloride-Month 4 | Chloride-Month 5 | Chloride-Month 6 | CO2-Baseline | CO2-Month 1 | CO2-Month 2 | CO2-Month 3 | CO2-Month 4 | CO2-Month 5 | CO2-Month 6 | |
| Prednisolone | 140 | 140 | 139 | 141 | 139 | 139 | 143 | 3.8 | 4 | 4.5 | 3.9 | 4.6 | 4.2 | 3.9 | 105 | 105 | 104 | 105 | 105 | 106 | 105 | 22 | 24 | 24 | 24 | 25 | 26 | 26 |
| Spironolactone | 142 | 142 | 141 | 142 | 139 | 139 | 140 | 4.5 | 4.7 | 4.2 | 4.1 | 4.5 | 4.5 | 4.3 | 103 | 109 | 107 | 103 | 103 | 103 | 101 | 29 | 22 | 25 | 27 | 28 | 28 | 26 |
1 review available for spironolactone and Lung Diseases
| Article | Year |
|---|---|
Neonatal diuretic therapy: furosemide, thiazides, and spironolactone.
Topics: Bronchopulmonary Dysplasia; Diuretics; Ductus Arteriosus, Patent; Furosemide; Humans; Infant, Newbor | 2012 |
Neonatal diuretic therapy: furosemide, thiazides, and spironolactone.
Topics: Bronchopulmonary Dysplasia; Diuretics; Ductus Arteriosus, Patent; Furosemide; Humans; Infant, Newbor | 2012 |
Neonatal diuretic therapy: furosemide, thiazides, and spironolactone.
Topics: Bronchopulmonary Dysplasia; Diuretics; Ductus Arteriosus, Patent; Furosemide; Humans; Infant, Newbor | 2012 |
Neonatal diuretic therapy: furosemide, thiazides, and spironolactone.
Topics: Bronchopulmonary Dysplasia; Diuretics; Ductus Arteriosus, Patent; Furosemide; Humans; Infant, Newbor | 2012 |
2 trials available for spironolactone and Lung Diseases
| Article | Year |
|---|---|
Impact of pulmonary disease on the prognosis in heart failure with preserved ejection fraction: the TOPCAT trial.
Topics: Heart Failure; Humans; Lung Diseases; Mineralocorticoid Receptor Antagonists; Prognosis; Spironolact | 2020 |
[Use of verospiron in chronic nonspecific lung diseases].
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Lung Diseases; Ma | 1975 |
5 other studies available for spironolactone and Lung Diseases
| Article | Year |
|---|---|
Clinical experience with spironolactone in pediatrics.
Topics: Chronic Disease; Diagnosis-Related Groups; Diuretics; Female; Heart Diseases; Humans; Hyperkalemia; | 2005 |
[Aldactone in the treatment of sarcoidosis of the lungs (author's transl)].
Topics: Biopsy; Cortisone; Drug Synergism; Humans; Lung Diseases; Sarcoidosis; Spironolactone | 1977 |
[The efficacy of spironolacton in cardiopulmonary insufficiency (author's transl)].
Topics: Animals; Bicarbonates; Blood Gas Analysis; Drug Evaluation; Guinea Pigs; Heart Diseases; Humans; Lun | 1976 |
The experimental production of hemorrhagic lesions in the rat adrenal, liver and lung by basic polyglutamic acid derivatives.
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Chemical and Drug Induced Liver Injury; Ethylestren | 1972 |
[Experimental study on teratology of spironolactone].
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Lung Diseases; Male; Mice; Pregnancy; Pregnancy | 1969 |