spironolactone has been researched along with Low Back Pain in 1 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Low Back Pain: Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The MR/GR agonist 6-α methylprednisolone, commonly injected for low back pain, reduced mechanical hypersensitivity when applied locally to the DRG but was less effective than fluticasone." | 3.80 | Blocking the mineralocorticoid receptor improves effectiveness of steroid treatment for low back pain in rats. ( Strong, JA; Xie, W; Ye, L; Zhang, JM, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, L | 1 |
| Xie, W | 1 |
| Strong, JA | 1 |
| Zhang, JM | 1 |
1 other study available for spironolactone and Low Back Pain
| Article | Year |
|---|---|
Blocking the mineralocorticoid receptor improves effectiveness of steroid treatment for low back pain in rats.
Topics: Androstadienes; Animals; Disease Models, Animal; Eplerenone; Fluticasone; Ganglia, Spinal; Inflammat | 2014 |