spironolactone has been researched along with Long QT Syndrome in 5 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Further, this is the first study demonstrating amiloride could also improve myocardial fibrosis." | 9.17 | Myocardial fibrosis and QTc are reduced following treatment with spironolactone or amiloride in stroke survivors: a randomised placebo-controlled cross-over trial. ( MacWalter, RS; McSwiggan, S; Ogston, SA; Struthers, AD; Sze, KY; Wong, KY; Wong, SY, 2013) |
| " Further, this is the first study demonstrating amiloride could also improve myocardial fibrosis." | 5.17 | Myocardial fibrosis and QTc are reduced following treatment with spironolactone or amiloride in stroke survivors: a randomised placebo-controlled cross-over trial. ( MacWalter, RS; McSwiggan, S; Ogston, SA; Struthers, AD; Sze, KY; Wong, KY; Wong, SY, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vaksmann, G | 1 |
| Lucidarme, S | 1 |
| Henriet, E | 1 |
| Wong, KY | 1 |
| Wong, SY | 1 |
| McSwiggan, S | 1 |
| Ogston, SA | 1 |
| Sze, KY | 1 |
| MacWalter, RS | 1 |
| Struthers, AD | 1 |
| Maule, S | 1 |
| Bertello, C | 1 |
| Rabbia, F | 1 |
| Milan, A | 1 |
| Mulatero, P | 1 |
| Milazzo, V | 1 |
| Papotti, G | 1 |
| Veglio, F | 1 |
| Etheridge, SP | 1 |
| Compton, SJ | 1 |
| Tristani-Firouzi, M | 1 |
| Mason, JW | 1 |
| Csanády, M | 1 |
1 trial available for spironolactone and Long QT Syndrome
| Article | Year |
|---|---|
Myocardial fibrosis and QTc are reduced following treatment with spironolactone or amiloride in stroke survivors: a randomised placebo-controlled cross-over trial.
Topics: Aged; Amiloride; Cross-Over Studies; Diuretics; Double-Blind Method; Female; Fibrosis; Heart Disease | 2013 |
4 other studies available for spironolactone and Long QT Syndrome
| Article | Year |
|---|---|
Fetal ventricular tachycardia: betablockers should be the first line treatment.
Topics: Adrenergic beta-Antagonists; Adult; Diuretics; Female; Fetal Diseases; Fetal Monitoring; Humans; Inf | 2021 |
Ventricular repolarization before and after treatment in patients with secondary hypertension due to renal-artery stenosis and primary aldosteronism.
Topics: Adrenalectomy; Adult; Aged; Angioplasty; Blood Pressure; Electrocardiography; Female; Heart Ventricl | 2011 |
A new oral therapy for long QT syndrome: long-term oral potassium improves repolarization in patients with HERG mutations.
Topics: Administration, Oral; Adolescent; Adult; Cation Transport Proteins; Child; Dietary Supplements; Diur | 2003 |
More on the history of arrhythmia in long QT syndrome.
Topics: Arrhythmias, Cardiac; Cation Transport Proteins; Diuretics; DNA-Binding Proteins; ERG1 Potassium Cha | 2004 |