spironolactone has been researched along with Liver Neoplasms in 8 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Coexistent hepatocellular carcinoma (HCC) was the only significant predictive variable that attenuated the efficacy of TLV." | 5.46 | Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma. ( Goya, T; Kato, M; Kohjima, M; Kotoh, K; Masumoto, A; Miyazaki, M; Motomura, K; Senjyu, T; Tanaka, K; Yada, M, 2017) |
| " Patients with edema, ascites, or both had significantly greater elevation of plasma aldosterone levels compared to nonedematous patients; these patients also demonstrated a substantial degree of hepatic dysfunction as evidenced by lower serum albumin levels and higher bilirubin and alkaline phosphatase levels." | 3.66 | Hyperaldosteronism associated with liver metastases. ( Citrin, DL; Crowley, J; Pandya, KJ; Whitehead, R, 1980) |
| "Coexistent hepatocellular carcinoma (HCC) was the only significant predictive variable that attenuated the efficacy of TLV." | 1.46 | Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma. ( Goya, T; Kato, M; Kohjima, M; Kotoh, K; Masumoto, A; Miyazaki, M; Motomura, K; Senjyu, T; Tanaka, K; Yada, M, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miyazaki, M | 1 |
| Yada, M | 1 |
| Tanaka, K | 1 |
| Senjyu, T | 1 |
| Goya, T | 1 |
| Motomura, K | 1 |
| Kohjima, M | 1 |
| Kato, M | 1 |
| Masumoto, A | 1 |
| Kotoh, K | 1 |
| Simó-Servat, A | 1 |
| Peiró, I | 1 |
| Villabona, C | 1 |
| Springer, J | 1 |
| Tschirner, A | 1 |
| Haghikia, A | 1 |
| von Haehling, S | 1 |
| Lal, H | 1 |
| Grzesiak, A | 1 |
| Kaschina, E | 1 |
| Palus, S | 1 |
| Pötsch, M | 1 |
| von Websky, K | 1 |
| Hocher, B | 1 |
| Latouche, C | 1 |
| Jaisser, F | 1 |
| Morawietz, L | 1 |
| Coats, AJ | 1 |
| Beadle, J | 1 |
| Argiles, JM | 1 |
| Thum, T | 1 |
| Földes, G | 1 |
| Doehner, W | 1 |
| Hilfiker-Kleiner, D | 1 |
| Force, T | 1 |
| Anker, SD | 1 |
| Lee, HJ | 1 |
| Rho, J | 1 |
| Gui, SR | 1 |
| Kim, MK | 1 |
| Lee, YK | 1 |
| Lee, YS | 1 |
| Kim, JE | 1 |
| Cho, E | 1 |
| Cho, M | 1 |
| Hwang, TH | 1 |
| Li, D | 1 |
| Cai, H | 1 |
| Jiang, B | 1 |
| Liu, G | 1 |
| Wang, Y | 1 |
| Wang, L | 1 |
| Yao, H | 1 |
| Wu, X | 1 |
| Sun, Y | 1 |
| Xu, J | 1 |
| Pandya, KJ | 1 |
| Whitehead, R | 1 |
| Crowley, J | 1 |
| Citrin, DL | 1 |
| Reynolds, ES | 1 |
| Moslen, MT | 1 |
| Szabo, S | 1 |
| Jaeger, RJ | 1 |
| Murphy, SD | 1 |
| Yamada, S | 1 |
| Reynolds, TB | 1 |
1 trial available for spironolactone and Liver Neoplasms
| Article | Year |
|---|---|
Amiloride (MK-870), a new antikaluretic diuretic. Comparison to other antikaluretic diuretics in patients with liver disease and ascites.
Topics: Acid-Base Equilibrium; Amidines; Ascites; Autopsy; Carcinoma; Diuretics; Ethacrynic Acid; Humans; Hy | 1970 |
7 other studies available for spironolactone and Liver Neoplasms
| Article | Year |
|---|---|
Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma.
Topics: Aged; Aged, 80 and over; Antidiuretic Hormone Receptor Antagonists; Ascites; Benzazepines; Body Weig | 2017 |
Corticotropin secreting pancreatic neuroendocrine tumour, a therapeutic management challenge. A presentation of 2 cases.
Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Chromogranins; Combined Modality Therapy; Embol | 2019 |
Prevention of liver cancer cachexia-induced cardiac wasting and heart failure.
Topics: Adrenergic beta-1 Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Bisoprolo | 2014 |
Effect of aldosterone on the amplification of oncolytic vaccinia virus in human cancer lines.
Topics: Aldosterone; Amiloride; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Hydrocortisone | 2011 |
Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Diterpenes; Diterpenes, Kaurane; Flo | 2013 |
Hyperaldosteronism associated with liver metastases.
Topics: Aldosterone; Alkaline Phosphatase; Ascites; Bilirubin; Edema; Female; Humans; Hyperaldosteronism; Li | 1980 |
Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.
Topics: Animals; Aroclors; Carcinogens; Cell Membrane; Cytochrome P-450 Enzyme System; Dichloroethylenes; En | 1975 |