spironolactone has been researched along with Liver Cirrhosis, Alcoholic in 23 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Liver Cirrhosis, Alcoholic: FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was undertaken to determine whether or not spironolactone could induce drug-metabolizing enzymes in patients with ascites due to alcoholic cirrhosis of the liver." | 9.05 | Spironolactone and enzyme induction in patients with alcoholic cirrhosis. ( Dhumeaux, D; Joanne, C; Miguet, JP; Thebault-Lucas, A; Vuitton, D, 1980) |
| "We have studied the efficacy of urea in the treatment of hyponatremia and hydrosaline retention in cirrhotic patients with ascites resistant to diuretics." | 7.67 | Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. ( Cauchie, P; Decaux, G; Delwiche, F; Flamion, B; Mols, P, 1986) |
| "Ten patients with ascites due to chronic liver disease were treated with spironolactone as the sole diuretic in doses of 300 to 600 mg daily." | 7.66 | Effectiveness of high-dose spironolactone therapy in patients with chronic liver disease and relatively refractory ascites. ( Campra, JL; Reynolds, TB, 1978) |
| "Six patients with alcoholic cirrhosis developed a reversible metabolic acidosis during treatment with the aldosterone antagonist spironolactone." | 7.66 | Spironolactone-induced hyperchloremic acidosis in cirrhosis. ( Gabow, PA; Moore, S; Schrier, RW, 1979) |
| "Plasma levels of canrenone and androgen receptor-active materials (ARM) were determined during long-term oral K-canrenoate or spironolactone therapy in cirrhotics with chronic recurrent ascites." | 5.06 | Canrenone and androgen receptor-active materials in plasma of cirrhotic patients during long-term K-canrenoate or spironolactone therapy. ( Andriulli, A; Armanini, D; Arrigoni, A; Buzzetti, G; Gindro, T; Karbowiak, I, 1989) |
| "The present study was undertaken to determine whether or not spironolactone could induce drug-metabolizing enzymes in patients with ascites due to alcoholic cirrhosis of the liver." | 5.05 | Spironolactone and enzyme induction in patients with alcoholic cirrhosis. ( Dhumeaux, D; Joanne, C; Miguet, JP; Thebault-Lucas, A; Vuitton, D, 1980) |
| "Twenty-seven patients with nonazotemic liver cirrhosis and ascites were initially treated with spironolactone, 200 mg/day." | 3.70 | Predictive factors influencing the therapeutic response to diuretic treatment of ascites in nonazotemic cirrhotic patients. ( Banić, M; Kujundzić, M; Ljubicić, N; Vrkljan, M, 1998) |
| "We have studied the efficacy of urea in the treatment of hyponatremia and hydrosaline retention in cirrhotic patients with ascites resistant to diuretics." | 3.67 | Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. ( Cauchie, P; Decaux, G; Delwiche, F; Flamion, B; Mols, P, 1986) |
| "Ten patients with ascites due to chronic liver disease were treated with spironolactone as the sole diuretic in doses of 300 to 600 mg daily." | 3.66 | Effectiveness of high-dose spironolactone therapy in patients with chronic liver disease and relatively refractory ascites. ( Campra, JL; Reynolds, TB, 1978) |
| "Six patients with alcoholic cirrhosis developed a reversible metabolic acidosis during treatment with the aldosterone antagonist spironolactone." | 3.66 | Spironolactone-induced hyperchloremic acidosis in cirrhosis. ( Gabow, PA; Moore, S; Schrier, RW, 1979) |
| " Hepatic microsomal reserve, defined as the difference between the basal and phenobarbital-stimulated ABT, was therefore studied in eight healthy control subjects and 12 patients with stable alcoholic cirrhosis." | 3.66 | Decreased hepatic microsomal reserve in patients with cirrhosis. Studies using aminopyrine as model drug. ( Hepner, GW; Piken, E, 1979) |
| "The origin of the pleural effusion is a decompensated liver cirrhosis without ascites." | 1.32 | [Massive unilateral hydrothorax as clinical manifestation of decompensated liver cirrhosis without ascites]. ( Camartin, C; Kuhn, M; Reinhart, WH, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (65.22) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perri, GA | 1 |
| FLANDRIN, P | 1 |
| GROULADE, J | 1 |
| HOLLARD, D | 1 |
| RACHAIL, M | 1 |
| TOLOT, F | 1 |
| ROULLET, A | 1 |
| SALLE, B | 1 |
| JOUD, R | 1 |
| POULET, R | 1 |
| EVREUX, P | 1 |
| GIRARD, M | 1 |
| FRAISSE, H | 1 |
| ETAIX, JP | 1 |
| Camartin, C | 1 |
| Reinhart, WH | 1 |
| Kuhn, M | 1 |
| Merino Angulo, J | 1 |
| Bilbao Ercoreca, F | 1 |
| del Villar Negro, A | 1 |
| de la Riva Aguinaco, C | 1 |
| Aguirre Errasti, C | 1 |
| Pérez-Ayuso, RM | 1 |
| Arroyo, V | 1 |
| Planas, R | 1 |
| Gaya, J | 1 |
| Bory, F | 1 |
| Rimola, A | 1 |
| Rivera, F | 1 |
| Rodés, J | 1 |
| Zipser, RD | 1 |
| Kerlin, P | 1 |
| Hoefs, JC | 1 |
| Zia, P | 1 |
| Barg, A | 1 |
| Miguet, JP | 1 |
| Vuitton, D | 1 |
| Thebault-Lucas, A | 1 |
| Joanne, C | 1 |
| Dhumeaux, D | 1 |
| Zapater, P | 1 |
| Alba, D | 1 |
| Ljubicić, N | 2 |
| Bilić, A | 1 |
| Kopjar, B | 1 |
| Kujundzić, M | 1 |
| Banić, M | 1 |
| Vrkljan, M | 1 |
| Aagaard, NK | 1 |
| Andersen, H | 1 |
| Vilstrup, H | 1 |
| Clausen, T | 1 |
| Jakobsen, J | 1 |
| Dørup, I | 1 |
| Campra, JL | 1 |
| Reynolds, TB | 1 |
| Gabow, PA | 1 |
| Moore, S | 1 |
| Schrier, RW | 1 |
| Piken, E | 1 |
| Hepner, GW | 1 |
| Vetter, H | 1 |
| Vetter, W | 1 |
| Beckerhoff, R | 1 |
| Glänzer, K | 1 |
| Furrer, J | 1 |
| Hahn, C | 1 |
| Kolloch, R | 1 |
| Krück, F | 1 |
| Kutz, K | 1 |
| Siegenthaler, W | 1 |
| Witassek, F | 1 |
| Hagège, H | 1 |
| Ink, O | 1 |
| Ducreux, M | 1 |
| Pelletier, G | 1 |
| Buffet, C | 1 |
| Etienne, JP | 1 |
| Duclos, B | 1 |
| Bories, P | 1 |
| Mathieu-Daude, JC | 1 |
| Michel, H | 1 |
| Andriulli, A | 1 |
| Arrigoni, A | 1 |
| Gindro, T | 1 |
| Karbowiak, I | 1 |
| Buzzetti, G | 1 |
| Armanini, D | 1 |
| Wathen, CG | 1 |
| MacDonald, T | 1 |
| Wise, LA | 1 |
| Boyd, SM | 1 |
| Decaux, G | 1 |
| Mols, P | 1 |
| Cauchie, P | 1 |
| Flamion, B | 1 |
| Delwiche, F | 1 |
5 trials available for spironolactone and Liver Cirrhosis, Alcoholic
| Article | Year |
|---|---|
Randomized comparative study of efficacy of furosemide versus spironolactone in nonazotemic cirrhosis with ascites. Relationship between the diuretic response and the activity of the renin-aldosterone system.
Topics: Ascites; Clinical Trials as Topic; Diuresis; Dose-Response Relationship, Drug; Furosemide; Humans; L | 1983 |
Spironolactone and enzyme induction in patients with alcoholic cirrhosis.
Topics: Adult; Aged; Antipyrine; Body Weight; Drug Interactions; Enzyme Induction; Female; Furosemide; Human | 1980 |
Diuretics vs. paracentesis followed by diuretics in cirrhosis: effect on ascites opsonic activity and immunoglobulin and complement concentrations.
Topics: Adult; Aged; Ascites; Ascitic Fluid; Blood Cell Count; Chemotherapy, Adjuvant; Complement C3; Comple | 1994 |
[Treatment of ascites in patients with liver cirrhosis without neither hyponatremia nor renal insufficiency. Results of a randomized study comparing diuretics and punctures compensated by albumin].
Topics: Aged; Albumins; Ascites; Combined Modality Therapy; Drug Therapy, Combination; Female; Furosemide; H | 1992 |
Canrenone and androgen receptor-active materials in plasma of cirrhotic patients during long-term K-canrenoate or spironolactone therapy.
Topics: Adult; Aged; Ascites; Canrenoic Acid; Canrenone; Chronic Disease; Clinical Trials as Topic; Double-B | 1989 |
18 other studies available for spironolactone and Liver Cirrhosis, Alcoholic
| Article | Year |
|---|---|
Ascites in patients with cirrhosis.
Topics: Abdominal Pain; Aged; Analgesics, Opioid; Ascites; Catheters, Indwelling; Diet, Sodium-Restricted; D | 2013 |
[Study of the action of spirolactone in edematous alcoholic cirrhosis].
Topics: Aldosterone; Diuretics; Edema; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Mineralocorticoid Recept | 1961 |
[Use of spironolactone in 2 cases of ascitic alcoholic cirrhosis refractory to the usual treatment].
Topics: Aldosterone; Humans; Liver Cirrhosis, Alcoholic; Mineralocorticoid Receptor Antagonists; Spironolact | 1961 |
[THE TREATMENT OF ALCOHOLIC CIRRHOSIS].
Topics: Adrenal Cortex Hormones; Alcoholism; Arginine; Diet; Diet Therapy; Diuretics; Folic Acid; Glutamates | 1963 |
[CONTRIBUTION TO THE STUDY OF THE ACTION OF TRIAMTERENE IN THE TREATMENT OF ALCOHOLIC CIRRHOSIS WITH ASCITES. (APROPOS OF 24 CASES)].
Topics: Ascites; Body Fluids; Diuretics; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Potassium; Pterins; Sp | 1964 |
[Massive unilateral hydrothorax as clinical manifestation of decompensated liver cirrhosis without ascites].
Topics: Diagnosis, Differential; Diuretics; Exudates and Transudates; Furosemide; Humans; Liver Cirrhosis, A | 2003 |
[Bilateral metastatic gynecomastia. An unusual manifestation of small-cell pulmonary carcinoma].
Topics: Breast Neoplasms; Carcinoma, Small Cell; Gynecomastia; Humans; Liver Cirrhosis, Alcoholic; Lung Neop | 1983 |
Renal kallikrein excretion in alcoholic cirrhosis. Relationship to other vasoactive systems.
Topics: Adult; Aldosterone; Creatinine; Humans; Kallikreins; Kidney; Liver Cirrhosis, Alcoholic; Middle Aged | 1981 |
Acidosis and extreme hyperkalemia associated with cholestyramine and spironolactone.
Topics: Acidosis; Cholestyramine Resin; Humans; Hyperkalemia; Hypertension, Portal; Liver Cirrhosis, Alcohol | 1995 |
Predictive factors influencing the therapeutic response to diuretic treatment of ascites in nonazotemic cirrhotic patients.
Topics: Ascites; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Liver Cirrhosis, Alcoholi | 1998 |
Muscle strength, Na,K-pumps, magnesium and potassium in patients with alcoholic liver cirrhosis -- relation to spironolactone.
Topics: Adult; Case-Control Studies; Cross-Sectional Studies; Denmark; Diuretics; Female; Humans; Linear Mod | 2002 |
Effectiveness of high-dose spironolactone therapy in patients with chronic liver disease and relatively refractory ascites.
Topics: Adult; Ascites; Blood Urea Nitrogen; Creatinine; Drug Evaluation; Female; Hepatitis, Alcoholic; Huma | 1978 |
Spironolactone-induced hyperchloremic acidosis in cirrhosis.
Topics: Acidosis; Adult; Aged; Bicarbonates; Chlorides; Female; Humans; Liver Cirrhosis, Alcoholic; Male; Mi | 1979 |
Decreased hepatic microsomal reserve in patients with cirrhosis. Studies using aminopyrine as model drug.
Topics: Adult; Aminopyrine; Antipyrine; Female; Humans; Liver Cirrhosis, Alcoholic; Male; Microsomes, Liver; | 1979 |
[Aldosterone and renin in liver cirrhosis with ascites].
Topics: Aldosterone; Ascites; Furosemide; Humans; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Renin; Spiron | 1977 |
Jejunal permeability to water and electrolytes in patients with chronic intrahepatic hypertension: evidence for a role of aldosterone.
Topics: Adult; Aged; Aldosterone; Chlorides; Electrolytes; Female; Humans; Hypertension, Portal; Intestinal | 1991 |
Eosinophilia associated with spironolactone.
Topics: Acute Disease; Aged; Drug Eruptions; Eosinophilia; Humans; Liver Cirrhosis, Alcoholic; Male; Middle | 1986 |
Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea.
Topics: Adult; Ascites; Body Weight; Creatinine; Drug Therapy, Combination; Edema; Furosemide; Humans; Hypon | 1986 |