spironolactone has been researched along with Liddle Syndrome in 1 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Liddle Syndrome: Familial pseudoaldosteronism characterized by autosomal dominant inheritance of hypertension with HYPOKALEMIA; ALKALOSIS; RENIN and ALDOSTERONE level decreases. It is caused by mutations in EPITHELIAL SODIUM CHANNELS beta and gamma subunits. Different mutations in the same EPITHELIAL SODIUM CHANNELS subunits can cause PSEUDOHYPOALDOSTERONISM, TYPE I, AUTOSOMAL DOMINANT.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus we diagnosed pseudoaldosteronism that was related to the long-term use of glycyrrhizin." | 1.36 | Pseudoaldosteronism with increased serum cortisol associated with pneumonia, hypouricemia, hypocalcemia, and hypophosphatemia. ( Asano, Y; Homma, S; Inaba, T; Kusano, E; Muto, S; Onishi, A; Shuto, R, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Onishi, A | 1 |
| Muto, S | 1 |
| Homma, S | 1 |
| Inaba, T | 1 |
| Shuto, R | 1 |
| Kusano, E | 1 |
| Asano, Y | 1 |
1 other study available for spironolactone and Liddle Syndrome
| Article | Year |
|---|---|
Pseudoaldosteronism with increased serum cortisol associated with pneumonia, hypouricemia, hypocalcemia, and hypophosphatemia.
Topics: Aged; Biomarkers; Glycyrrhizic Acid; Humans; Hydrocortisone; Hypocalcemia; Hypophosphatemia; Liddle | 2010 |