spironolactone has been researched along with Leucocythaemia in 1 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we evaluated the cytotoxic and NF-ĸB inhibition potential of new spiro(lactone-cyclohexanone) compounds in two different human leukemia cell lines (U937 and K562)." | 7.85 | Anti-proliferative, Cytotoxic and NF-ĸB Inhibitory Properties of Spiro(Lactone-Cyclohexanone) Compounds in Human Leukemia. ( Bachari, K; Bouhenna, MM; Diederich, M; Mameri, N; Orlikova, B; Pinto, DCGA; Schram, B; Silva, AMS; Taibi, N; Talhi, O, 2017) |
| " In this study, we evaluated the cytotoxic and NF-ĸB inhibition potential of new spiro(lactone-cyclohexanone) compounds in two different human leukemia cell lines (U937 and K562)." | 3.85 | Anti-proliferative, Cytotoxic and NF-ĸB Inhibitory Properties of Spiro(Lactone-Cyclohexanone) Compounds in Human Leukemia. ( Bachari, K; Bouhenna, MM; Diederich, M; Mameri, N; Orlikova, B; Pinto, DCGA; Schram, B; Silva, AMS; Taibi, N; Talhi, O, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bouhenna, MM | 1 |
| Orlikova, B | 1 |
| Talhi, O | 1 |
| Schram, B | 1 |
| Pinto, DCGA | 1 |
| Taibi, N | 1 |
| Bachari, K | 1 |
| Diederich, M | 1 |
| Silva, AMS | 1 |
| Mameri, N | 1 |
1 other study available for spironolactone and Leucocythaemia
| Article | Year |
|---|---|
Anti-proliferative, Cytotoxic and NF-ĸB Inhibitory Properties of Spiro(Lactone-Cyclohexanone) Compounds in Human Leukemia.
Topics: Biological Assay; Caspase 3; Caspase 7; Cell Death; Cell Proliferation; Cell Survival; Chromatograph | 2017 |