spironolactone has been researched along with Leiomyoma in 2 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Leiomyoma: A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of aldosterone increased the levels of Ang II type-1 receptor mRNA." | 5.36 | Aldosterone stimulates the proliferation of uterine leiomyoma cells. ( Isobe, A; Kimura, T; Li, B; Sakata, M; Takeda, T; Tsuiji, K; Wakabayashi, A; Yaegashi, N, 2010) |
| " Another patient was a 61-year-old man with gynecomastia induced by spironolactone of 6 months duration." | 3.78 | Two cases of male nipple leiomyoma: idiopathic leiomyoma and gynecomastia-associated leiomyoma. ( Hashimoto, Y; Iizuka, H; Ishida-Yamamoto, A; Mizumoto, T; Nakamura, S; Nishi, K; Takeda, K, 2012) |
| "Treatment of aldosterone increased the levels of Ang II type-1 receptor mRNA." | 1.36 | Aldosterone stimulates the proliferation of uterine leiomyoma cells. ( Isobe, A; Kimura, T; Li, B; Sakata, M; Takeda, T; Tsuiji, K; Wakabayashi, A; Yaegashi, N, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Isobe, A | 1 |
| Takeda, T | 1 |
| Wakabayashi, A | 1 |
| Tsuiji, K | 1 |
| Li, B | 1 |
| Sakata, M | 1 |
| Yaegashi, N | 1 |
| Kimura, T | 1 |
| Nakamura, S | 1 |
| Hashimoto, Y | 1 |
| Takeda, K | 1 |
| Nishi, K | 1 |
| Ishida-Yamamoto, A | 1 |
| Mizumoto, T | 1 |
| Iizuka, H | 1 |
2 other studies available for spironolactone and Leiomyoma
| Article | Year |
|---|---|
Aldosterone stimulates the proliferation of uterine leiomyoma cells.
Topics: Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Division; Cell L | 2010 |
Two cases of male nipple leiomyoma: idiopathic leiomyoma and gynecomastia-associated leiomyoma.
Topics: Actins; Aged; Breast Neoplasms, Male; Desmin; Gynecomastia; Humans; Leiomyoma; Male; Middle Aged; Mi | 2012 |