spironolactone has been researched along with Intracranial Aneurysm in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of the 82 patients, 80 (88 unruptured aneurysms) were followed for a mean of 21." | 2.87 | Treatment of Unruptured Cerebral Aneurysms with the Mineralocorticoid Receptor Blocker Eplerenone-Pilot Study. ( Abe, T; Harada, M; Kanematsu, Y; Kinouchi, T; Kitazato, KT; Korai, M; Kuwayama, K; Matsushita, N; Miyamoto, T; Mure, H; Nagahiro, S; Nakajima, K; Okayama, Y; Satomi, J; Shimada, K; Tada, Y; Yagi, K; Yamaguchi, T, 2018) |
| "The formation of cerebral aneurysms is associated with endothelial damage and macrophage migration." | 1.36 | Reduction of endothelial tight junction proteins is related to cerebral aneurysm formation in rats. ( Kageji, T; Kinouchi, T; Kitazato, KT; Matsushita, N; Nagahiro, S; Nakajima, N; Satomi, J; Shimada, K; Tada, Y; Tamura, T; Yagi, K, 2010) |
| "Eplerenone reduced the incidence of cerebral aneurysms and saline intake without lowering of the blood pressure." | 1.35 | Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats. ( Kinouchi, T; Kitazato, KT; Nagahiro, S; Satomi, J; Shimada, K; Tada, Y; Tamura, T; Yagi, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nagahiro, S | 3 |
| Tada, Y | 3 |
| Satomi, J | 3 |
| Kinouchi, T | 3 |
| Kuwayama, K | 1 |
| Yagi, K | 3 |
| Nakajima, K | 1 |
| Matsushita, N | 2 |
| Miyamoto, T | 1 |
| Yamaguchi, T | 1 |
| Shimada, K | 3 |
| Korai, M | 1 |
| Mure, H | 1 |
| Okayama, Y | 1 |
| Abe, T | 1 |
| Harada, M | 1 |
| Kitazato, KT | 3 |
| Kanematsu, Y | 1 |
| Tamura, T | 2 |
| Nakajima, N | 1 |
| Kageji, T | 1 |
| Slosberg, PS | 1 |
1 trial available for spironolactone and Intracranial Aneurysm
| Article | Year |
|---|---|
Treatment of Unruptured Cerebral Aneurysms with the Mineralocorticoid Receptor Blocker Eplerenone-Pilot Study.
Topics: Aged; Aneurysm, Ruptured; Brain; Disease Progression; Eplerenone; Female; Follow-Up Studies; Humans; | 2018 |
3 other studies available for spironolactone and Intracranial Aneurysm
| Article | Year |
|---|---|
Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats.
Topics: Aldosterone; Angiotensin II; Animals; Blood Pressure; Cerebral Arteries; Chemokine CCL2; Eplerenone; | 2009 |
Reduction of endothelial tight junction proteins is related to cerebral aneurysm formation in rats.
Topics: Animals; Base Sequence; Brain; Cells, Cultured; Chemokine CCL2; DNA Primers; Endothelial Cells; Eple | 2010 |
Symptomatic unruptured giant aneurysms: medical treatment.
Topics: Aged; Antihypertensive Agents; Female; Humans; Hydrochlorothiazide; Intracranial Aneurysm; Middle Ag | 1982 |