spironolactone has been researched along with Infarction, Middle Cerebral Artery in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aldosterone is a risk factor for stroke, and the literature suggests it may play a role in increasing the expression of the receptor for EGF (EGFR)." | 5.31 | Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats. ( Dorrance, AM; Grekin, R; Osborn, HL; Webb, RC, 2001) |
| "Brain edema was measured on day 5 by MRI, histochemical staining of brain sections and tissue water content determination (n=7, each experiment)." | 1.43 | Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na⁺/H⁺ exchanger 1 expression. ( Aono, H; Choudhury, ME; Fujita, T; Islam, A; Mise, A; Miyanishi, K; Nishioka, R; Sugimoto, K; Takahashi, H; Takeda, H; Tanaka, J; Yano, H, 2016) |
| "Treatment with eplerenone at a dose of 1." | 1.34 | Pretreatment with eplerenone reduces stroke volume in mouse middle cerebral artery occlusion model. ( Gao, XY; Horiuchi, M; Ide, A; Iwai, M; Iwanami, J; Li, JM; Min, LJ; Mogi, M; Okamoto, S; Tsukuda, K, 2007) |
| "Aldosterone is a risk factor for stroke, and the literature suggests it may play a role in increasing the expression of the receptor for EGF (EGFR)." | 1.31 | Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats. ( Dorrance, AM; Grekin, R; Osborn, HL; Webb, RC, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nishioka, R | 1 |
| Sugimoto, K | 1 |
| Aono, H | 1 |
| Mise, A | 1 |
| Choudhury, ME | 1 |
| Miyanishi, K | 1 |
| Islam, A | 1 |
| Fujita, T | 1 |
| Takeda, H | 1 |
| Takahashi, H | 1 |
| Yano, H | 1 |
| Tanaka, J | 1 |
| Frieler, RA | 1 |
| Ray, JJ | 1 |
| Meng, H | 1 |
| Ramnarayanan, SP | 1 |
| Usher, MG | 1 |
| Su, EJ | 1 |
| Berger, S | 1 |
| Pinsky, DJ | 1 |
| Lawrence, DA | 1 |
| Wang, MM | 1 |
| Mortensen, RM | 1 |
| Iwanami, J | 1 |
| Mogi, M | 1 |
| Okamoto, S | 1 |
| Gao, XY | 1 |
| Li, JM | 1 |
| Min, LJ | 1 |
| Ide, A | 1 |
| Tsukuda, K | 1 |
| Iwai, M | 1 |
| Horiuchi, M | 1 |
| Dorrance, AM | 1 |
| Osborn, HL | 1 |
| Grekin, R | 1 |
| Webb, RC | 1 |
4 other studies available for spironolactone and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na⁺/H⁺ exchanger 1 expression.
Topics: Acid Sensing Ion Channel Blockers; Animals; Aquaporin 4; Brain Edema; Cells, Cultured; Corticosteron | 2016 |
Myeloid mineralocorticoid receptor during experimental ischemic stroke: effects of model and sex.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Eplerenone; Female; Gene Expression Profiling; Immu | 2012 |
Pretreatment with eplerenone reduces stroke volume in mouse middle cerebral artery occlusion model.
Topics: Animals; Blood Pressure; Brain Ischemia; Disease Models, Animal; Eplerenone; Infarction, Middle Cere | 2007 |
Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats.
Topics: Aldosterone; Animals; Aorta; Basal Ganglia; Blood Pressure; Body Weight; Cerebral Cortex; Cerebral I | 2001 |