spironolactone has been researched along with Hypophosphatasia in 1 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Hypophosphatasia: A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In an 18-year-old boy with Bartter's syndrome, hypophosphatemia was discovered (2." | 1.26 | Hypophosphatemia and hyperparathyroidism in a case of Bartter's syndrome. ( Bernheim, J; David, L; François, R; Sann, L, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sann, L | 1 |
| David, L | 1 |
| Bernheim, J | 1 |
| François, R | 1 |
1 other study available for spironolactone and Hypophosphatasia
| Article | Year |
|---|---|
Hypophosphatemia and hyperparathyroidism in a case of Bartter's syndrome.
Topics: Adolescent; Alkalosis; Bartter Syndrome; Humans; Hyperaldosteronism; Hyperparathyroidism; Hypokalemi | 1978 |