spironolactone has been researched along with Hyponatremia in 52 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Hyponatremia: Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)
Excerpt | Relevance | Reference |
---|---|---|
" To investigate the effects of the addition of a vasopressin V(2) receptor antagonist, satavaptan, to 100mg spironolactone on ascites recurrence after a large volume paracentesis in patients with liver cirrhosis irrespective of the presence of hyponatraemia." | 9.14 | Effects of a selective vasopressin V2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosis. ( Angeli, P; Bernardi, M; Gines, P; Gow, P; Horsmans, Y; Minini, P; Watson, H; Wong, F, 2010) |
"This study was designed to investigate the appropriateness and complications of the use of spironolactone for heart failure (HF) in clinical practice." | 9.10 | Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines. ( Agoston, I; Bozkurt, B; Knowlton, AA, 2003) |
" We investigated the association of clinical variables and cardiovascular drugs, including furosemide, hydrochlorothiazide, spironolactone, and their doses, with the presence of hyponatremia at admission." | 7.96 | Furosemide and spironolactone doses and hyponatremia in patients with heart failure. ( Bušić, Ž; Čulić, V; Jurić Paić, M; Velat, I, 2020) |
"This paper details the case of a 26-year-old woman with depletion syndrome and the effectiveness of her treatment with indomethacin." | 7.85 | Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma. ( Kagan, MD; Sangha, G; Schmidt, K, 2017) |
"We have studied the efficacy of urea in the treatment of hyponatremia and hydrosaline retention in cirrhotic patients with ascites resistant to diuretics." | 7.67 | Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. ( Cauchie, P; Decaux, G; Delwiche, F; Flamion, B; Mols, P, 1986) |
"To evaluate the role of the renin-angiotensin system and sodium depletion in the hypotensive response to 1-sarcosine-8-alanine-angiotensin II (saralasin), 15 male patients with essential hypertension were studied on a diet containing 120 mEq of sodium and 100 mEq of potassium per day." | 7.66 | Angiotensin II, plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension. ( Barrett, JD; Eggena, P; Golub, MS; Sambhi, MP; Thananopavarn, C, 1980) |
"Spironolactone was evaluated as a diuretic in the therapy of six patients with chronic severe congestive heart failure, during which metabolic balance studies were performed." | 7.64 | EFFECT OF AN ALDOSTERONE ANTAGONIST (SPIRONOLACTONE) ON PATIENTS WITH SEVERE CONGESTIVE HEART FAILURE. ( CARRUTHERS, BM; LEDRAY, RD; MCINTOSH, HW; SERAGLIA, M; WALSH, GC, 1963) |
" To investigate the effects of the addition of a vasopressin V(2) receptor antagonist, satavaptan, to 100mg spironolactone on ascites recurrence after a large volume paracentesis in patients with liver cirrhosis irrespective of the presence of hyponatraemia." | 5.14 | Effects of a selective vasopressin V2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosis. ( Angeli, P; Bernardi, M; Gines, P; Gow, P; Horsmans, Y; Minini, P; Watson, H; Wong, F, 2010) |
"This study was designed to investigate the appropriateness and complications of the use of spironolactone for heart failure (HF) in clinical practice." | 5.10 | Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines. ( Agoston, I; Bozkurt, B; Knowlton, AA, 2003) |
" We investigated the association of clinical variables and cardiovascular drugs, including furosemide, hydrochlorothiazide, spironolactone, and their doses, with the presence of hyponatremia at admission." | 3.96 | Furosemide and spironolactone doses and hyponatremia in patients with heart failure. ( Bušić, Ž; Čulić, V; Jurić Paić, M; Velat, I, 2020) |
"This paper details the case of a 26-year-old woman with depletion syndrome and the effectiveness of her treatment with indomethacin." | 3.85 | Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma. ( Kagan, MD; Sangha, G; Schmidt, K, 2017) |
"To determine if the administration of an angiotensin-converting enzyme inhibitor (ACEI) plus spironolactone caused hyperkalemia, hypermagnesemia, or hyponatremia in elderly small dogs with degenerative mitral valve disease (MVD)." | 3.74 | Influence of combined angiotensin-converting enzyme inhibitors and spironolactone on serum K+, Mg 2+, and Na+ concentrations in small dogs with degenerative mitral valve disease. ( Calvert, CA; Fallaw, TK; Rockwell, JE; Thomason, JD, 2007) |
"We have studied the efficacy of urea in the treatment of hyponatremia and hydrosaline retention in cirrhotic patients with ascites resistant to diuretics." | 3.67 | Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea. ( Cauchie, P; Decaux, G; Delwiche, F; Flamion, B; Mols, P, 1986) |
"To evaluate the role of the renin-angiotensin system and sodium depletion in the hypotensive response to 1-sarcosine-8-alanine-angiotensin II (saralasin), 15 male patients with essential hypertension were studied on a diet containing 120 mEq of sodium and 100 mEq of potassium per day." | 3.66 | Angiotensin II, plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension. ( Barrett, JD; Eggena, P; Golub, MS; Sambhi, MP; Thananopavarn, C, 1980) |
"In 8 out of 20 patients with chronic liver disease ascites was controlled with metolazone, 10 required additional amiloride or spironolactone to achieve control, and 2 were resistant to all diuretic therapy." | 3.65 | Use of metolazone in the treatment of ascites due to liver disease. ( Hillenbrand, P; Sherlock, S, 1971) |
"Spironolactone was evaluated as a diuretic in the therapy of six patients with chronic severe congestive heart failure, during which metabolic balance studies were performed." | 3.64 | EFFECT OF AN ALDOSTERONE ANTAGONIST (SPIRONOLACTONE) ON PATIENTS WITH SEVERE CONGESTIVE HEART FAILURE. ( CARRUTHERS, BM; LEDRAY, RD; MCINTOSH, HW; SERAGLIA, M; WALSH, GC, 1963) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 36 (69.23) | 18.7374 |
1990's | 4 (7.69) | 18.2507 |
2000's | 7 (13.46) | 29.6817 |
2010's | 4 (7.69) | 24.3611 |
2020's | 1 (1.92) | 2.80 |
Authors | Studies |
---|---|
Velat, I | 1 |
Bušić, Ž | 1 |
Jurić Paić, M | 1 |
Čulić, V | 1 |
Kagan, MD | 1 |
Schmidt, K | 1 |
Sangha, G | 1 |
Morris, MJ | 1 |
Na, ES | 1 |
Johnson, AK | 1 |
Wong, F | 1 |
Gines, P | 2 |
Watson, H | 1 |
Horsmans, Y | 1 |
Angeli, P | 1 |
Gow, P | 1 |
Minini, P | 1 |
Bernardi, M | 1 |
Salerno, F | 1 |
Cazzaniga, M | 1 |
Accordino, S | 1 |
Bozkurt, B | 1 |
Agoston, I | 1 |
Knowlton, AA | 1 |
FORLAND, M | 1 |
PULLMAN, TN | 1 |
CARRUTHERS, BM | 1 |
LEDRAY, RD | 1 |
SERAGLIA, M | 1 |
MCINTOSH, HW | 1 |
WALSH, GC | 1 |
STERNBERG, MS | 1 |
HAGEDORN, CW | 1 |
KALSER, MH | 1 |
ALBEAUX-FERNET, M | 1 |
ROMANI, JD | 1 |
CONTE, M | 1 |
FOUET, P | 1 |
JACOBS, C | 1 |
BAGROS, P | 1 |
ROYER, P | 1 |
DELAITRE, R | 1 |
MATHIEU, H | 1 |
GABILAN, JC | 1 |
RAYNAUD, C | 1 |
PASQUALINI, JR | 1 |
DEBRIS, P | 1 |
GERBEAUX, S | 1 |
HABIB, R | 1 |
MAHER, JF | 1 |
SCHREINER, GE | 1 |
Fujii, M | 1 |
Suto, H | 1 |
Goto, M | 1 |
Miki, Y | 1 |
Asai, N | 1 |
Shibata, H | 2 |
Thomason, JD | 1 |
Rockwell, JE | 1 |
Fallaw, TK | 1 |
Calvert, CA | 1 |
Handler, J | 1 |
Thananopavarn, C | 1 |
Golub, MS | 1 |
Eggena, P | 1 |
Barrett, JD | 1 |
Sambhi, MP | 1 |
Hirschl, MM | 1 |
Seidler, D | 1 |
Laggner, AN | 1 |
van Furth, WR | 1 |
Eelkman Rooda, SJ | 1 |
Schwinger, RH | 1 |
Lenaerts, A | 1 |
Codden, T | 1 |
Henry, JP | 1 |
Van Cauter, J | 1 |
Meunier, JC | 1 |
Ligny, G | 1 |
Taylor, JW | 1 |
Delavelle, F | 1 |
Becchio, J | 1 |
Fries, D | 1 |
Marone, C | 1 |
Beretta-Piccoli, C | 1 |
Weidmann, P | 1 |
Datey, KK | 1 |
Bhagat, SJ | 1 |
Barat, AK | 1 |
Surana, MC | 1 |
Gifford, RW | 1 |
Hagège, H | 1 |
Ink, O | 1 |
Ducreux, M | 1 |
Pelletier, G | 1 |
Buffet, C | 1 |
Etienne, JP | 1 |
Arroyo, V | 1 |
Badalamenti, S | 1 |
Greenberg, A | 1 |
Decaux, G | 1 |
Mols, P | 1 |
Cauchie, P | 1 |
Flamion, B | 1 |
Delwiche, F | 1 |
Sherlock, S | 4 |
Senewiratne, B | 3 |
Scott, A | 2 |
Walker, JG | 2 |
Wolf, LM | 1 |
Courtois, H | 1 |
Schrub, JC | 1 |
Raynaud, R | 1 |
Brochier, M | 1 |
Raynaud, P | 1 |
Fauchier, JP | 1 |
Greenblatt, DJ | 1 |
Koch-Weser, J | 1 |
Nitter-Hauge, S | 1 |
Brodwall, EK | 1 |
Rootwelt, K | 1 |
Dölle, W | 1 |
Paris, GL | 1 |
Macoul, KL | 1 |
Sánchez, A | 1 |
Anderton, JL | 1 |
Kincaid-Smith, P | 1 |
Reubi, FC | 1 |
Sobel, A | 1 |
Safar, M | 1 |
Milliez, P | 1 |
Hillenbrand, P | 1 |
Schmidt, P | 1 |
Rorive, G | 1 |
Christensen, BE | 1 |
Andrieu, J | 1 |
Lesueur, G | 1 |
Schwarzbach, W | 1 |
Haas, W | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Study for the Prevention of Ascites (SPA): Comparison of Fixed Doses of SR121463B Versus Placebo in the Reduction of Recurrence of Cirrhotic Ascites[NCT00501384] | Phase 2 | 151 participants (Actual) | Interventional | 2004-04-30 | Completed | ||
The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients With Ascites and Activation of Sympathetic Nervous System: a Randomized Double-Blind Placebo Controlled Study.[NCT00356226] | 64 participants | Interventional | 2000-10-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
7 reviews available for spironolactone and Hyponatremia
Article | Year |
---|---|
[Corticosterone-producing adrenal tumor].
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Corticosterone; Diagnosis, Differential; Humans; Hy | 2006 |
[Deoxycorticosterone-producing adrenal tumor].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Agents, Hormonal; Desoxycorticosterone; Diagn | 2006 |
Well tolerated spironolactone-related hyponatremia.
Topics: Aged, 80 and over; Diuretics; Female; Humans; Hyponatremia; Risk Factors; Spironolactone | 2008 |
[Value of diuretics and aldosterone antagonists in the treatment of heart failure].
Topics: Benzothiadiazines; Diuretics; Drug Interactions; Drug Resistance; Heart Failure; Humans; Hyponatremi | 1999 |
[Depletion therapy of chronic congestive heart failure].
Topics: Bloodletting; Carbonic Anhydrase Inhibitors; Chlorides; Diet, Sodium-Restricted; Digitalis Glycoside | 1968 |
Diuretics. II. Clinical considerations.
Topics: Administration, Oral; Aminophylline; Ascites; Calcium; Carbohydrate Metabolism; Carbonic Anhydrase I | 1971 |
Combination diuretic drug therapy.
Topics: Amiloride; Benzothiadiazines; Diet; Diuretics; Drug Therapy, Combination; Ethacrynic Acid; Furosemid | 1971 |
4 trials available for spironolactone and Hyponatremia
Article | Year |
---|---|
Effects of a selective vasopressin V2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosis.
Topics: Aged; Antidiuretic Hormone Receptor Antagonists; Ascites; Combined Modality Therapy; Creatinine; Diu | 2010 |
Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines.
Topics: Aged; Guideline Adherence; Heart Failure; Humans; Hyperkalemia; Hyponatremia; Hypotension; Male; Mid | 2003 |
[Use of demeclotetracycline in the treatment of hyponatremia in cirrhotic ascitis].
Topics: Adult; Aged; Ascites; Clinical Trials as Topic; Demeclocycline; Drug Therapy, Combination; Edema; Fe | 1977 |
[Treatment of ascites in patients with liver cirrhosis without neither hyponatremia nor renal insufficiency. Results of a randomized study comparing diuretics and punctures compensated by albumin].
Topics: Aged; Albumins; Ascites; Combined Modality Therapy; Drug Therapy, Combination; Female; Furosemide; H | 1992 |
41 other studies available for spironolactone and Hyponatremia
Article | Year |
---|---|
Furosemide and spironolactone doses and hyponatremia in patients with heart failure.
Topics: Aged; Aged, 80 and over; Diuretics; Female; Furosemide; Heart Failure; Hospitalization; Humans; Hydr | 2020 |
Indomethacin therapy effective in a patient with depletion syndrome from secretory villous adenoma.
Topics: Adenoma, Villous; Adult; Cyclooxygenase Inhibitors; Diuretics; Drug Therapy, Combination; Female; Hu | 2017 |
Mineralocorticoid receptor antagonism prevents hedonic deficits induced by a chronic sodium appetite.
Topics: Aldosterone; Animals; Appetite; Captopril; Desoxycorticosterone; Drug Interactions; Furosemide; Hypo | 2010 |
May vaptans contribute to the treatment of refractory ascites?
Topics: Antidiuretic Hormone Receptor Antagonists; Ascites; Combined Modality Therapy; Diuretics; Dose-Respo | 2010 |
Electrolyte complications of drug therapy.
Topics: Alkalosis; Anatomy; Carbonic Anhydrases; Diuretics; Electrolytes; Estrogens; Humans; Hypercalcemia; | 1963 |
EFFECT OF AN ALDOSTERONE ANTAGONIST (SPIRONOLACTONE) ON PATIENTS WITH SEVERE CONGESTIVE HEART FAILURE.
Topics: Aldosterone; Antihypertensive Agents; Body Fluids; Diuresis; Diuretics; Female; Geriatrics; Heart Fa | 1963 |
THE USE OF SPIRONOLACTONE AND LARGE DOSES OF STEROIDS IN THE TREATMENT OF ASCITES OF LIVER DISEASE.
Topics: Adrenal Cortex Hormones; Ascites; Chlorothiazide; Diuresis; Hepatic Encephalopathy; Humans; Hyponatr | 1963 |
[LIMITS OF TREATMENT OF CIRRHOSIS WITH DIURETICS (SALDIURETICS AND ALDOSTERONE ANTAGONISTS)].
Topics: Ascites; Diuretics; Humans; Hyperkalemia; Hyponatremia; Liver Cirrhosis; Mineralocorticoid Receptor | 1963 |
[WATER RETENTION IN CIRRHOTICS. PHYSIOPATHOLOGICAL DATA AND THERAPEUTIC RESULTS].
Topics: Ascites; Edema; Heart Failure; Humans; Hypokalemia; Hyponatremia; Liver Cirrhosis; Mineralocorticoid | 1963 |
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS].
Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics; | 1964 |
[CHRONIC IDIOPATHIC HYPOKALEMIA WITH HYPERKALIURIA IN CHILDREN].
Topics: Adrenal Glands; Aldosterone; Blood Platelet Disorders; Blood Platelets; Child; Corticosterone; Dwarf | 1964 |
STUDIES ON ETHACRYNIC ACID IN PATIENTS WITH REFRACTORY EDEMA.
Topics: Alkalosis; Blood; Chlorides; Creatine; Creatinine; Diuretics; Drug Therapy; Edema; Ethacrynic Acid; | 1965 |
[Water-electrolyte imbalance: Reality in diagnosis and therapy (discussion)].
Topics: Acid-Base Equilibrium; Acidosis; Diagnosis, Differential; Extracellular Fluid; Humans; Hypercalcemia | 2006 |
Influence of combined angiotensin-converting enzyme inhibitors and spironolactone on serum K+, Mg 2+, and Na+ concentrations in small dogs with degenerative mitral valve disease.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diuretics; Dog Diseases; Dogs; Drug Interactions; | 2007 |
Angiotensin II, plasma renin and sodium depletion as determinants of blood pressure response to saralasin in essential hypertension.
Topics: Adult; Aged; Angiotensin II; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combina | 1980 |
Spironolactone-associated hyponatremic coma.
Topics: Aged; Aged, 80 and over; Coma; Female; Humans; Hyponatremia; Spironolactone | 1994 |
[A little less sodium is not without hazard].
Topics: Diagnosis, Differential; Female; Humans; Hyponatremia; Inappropriate ADH Syndrome; Male; Middle Aged | 1993 |
[Biological factors influencing response to diuretics in patients with cirrhosis and ascites].
Topics: Aldosterone; Ascites; Diuretics; Female; Furosemide; Glomerular Filtration Rate; Humans; Hyperkalemi | 2001 |
Mental symptoms and electrolyte imbalance.
Topics: Aged; Chlorine; Cognition Disorders; Confusion; Depression; Diuretics; Female; Humans; Hyponatremia; | 1979 |
[Basis and clinical aspects of diuretic drug therapy].
Topics: Acetazolamide; Benzothiadiazines; Diuretics; Edema; Edema, Cardiac; Furosemide; Glaucoma; Humans; Hy | 1979 |
Management of intractable heart failure with hyponatremia.
Topics: Adult; Aged; Dexamethasone; Drug Therapy, Combination; Female; Furosemide; Heart Failure; Humans; Hy | 1978 |
A guide to the practical use of diuretics.
Topics: Administration, Oral; Diuretics; Edema; Furosemide; Humans; Hypercalcemia; Hyperglycemia; Hypertensi | 1976 |
Refractory ascites: definition and mechanism.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ascites; Diet, Sodium-Restricted; Diuretics; Drainage; Drug | 1987 |
What's new in diuretic therapy.
Topics: Acetazolamide; Acid-Base Imbalance; Biological Transport; Diuretics; Drug Resistance; Ethacrynic Aci | 1986 |
Treatment of hyponatremic cirrhosis with ascites resistant to diuretics by urea.
Topics: Adult; Ascites; Body Weight; Creatinine; Drug Therapy, Combination; Edema; Furosemide; Humans; Hypon | 1986 |
Complications of diuretic therapy in hepatic cirrhosis.
Topics: Chlorothiazide; Diuretics; Ethacrynic Acid; Furosemide; Hepatic Encephalopathy; Humans; Hypokalemia; | 1966 |
Amiloride ('MK 870') in patients with ascites due to cirrhosis of the liver.
Topics: Adult; Ascites; Bicarbonates; Creatinine; Diuretics; Ethacrynic Acid; Furosemide; Guanidines; Humans | 1968 |
[Hypercalcemia and thiazides].
Topics: Benzothiadiazines; Diabetic Angiopathies; Diuretics; Drug Synergism; Edema; Female; Humans; Hypercal | 1973 |
[Hyperkalemias in cardiac patients].
Topics: Acidosis; Acute Kidney Injury; Adult; Aged; Arrhythmias, Cardiac; Digitalis Glycosides; Diuretics; F | 1974 |
Adverse reactions to spironolactone. A report from the Boston Collaborative Drug Surveillance Program.
Topics: Adult; Aged; Blood Urea Nitrogen; Coma; Dehydration; Diarrhea; Female; Gynecomastia; Headache; Heart | 1973 |
[Hyponatremia syndrome in congestive heart failure].
Topics: Female; Furosemide; Heart Failure; Humans; Hyponatremia; Middle Aged; Sodium; Spironolactone; Syndro | 1973 |
[Pathogenesis and therapy of ascites in liver cirrhosis].
Topics: Acid-Base Equilibrium; Alkalosis; Ascites; Deficiency Diseases; Diet; Diuresis; Diuretics; Furosemid | 1966 |
Reversible bullous retinal detachment in chronic renal disease.
Topics: Adult; Angiography; Diet; Female; Fluorescence; Humans; Hydrochlorothiazide; Hypertension, Renal; Hy | 1969 |
[Water-sodium depletion and clonidine in severe arterial hypertension].
Topics: Adult; Antihypertensive Agents; Body Weight; Clonidine; Creatinine; Drug Synergism; Electrocardiogra | 1972 |
Use of metolazone in the treatment of ascites due to liver disease.
Topics: Adult; Ascites; Chlorides; Chronic Disease; Diuretics; Female; Hepatic Encephalopathy; Humans; Hypok | 1971 |
[Diuresis and diuretics].
Topics: Acetazolamide; Acute Disease; Agranulocytosis; Anuria; Biological Transport; Blood Platelet Disorder | 1971 |
The complications of diuretic therapy in patients with cirrhosis.
Topics: Alkalosis; Ascites; Blood Urea Nitrogen; Chlorothiazide; Ethacrynic Acid; Furosemide; Hepatic Enceph | 1966 |
[Apropos of certain secondary effects of diuretics].
Topics: Blood Volume; Diabetes Mellitus; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hyperkalemia; Hypon | 1968 |
[Metyrapone incombination with spironolactone and prednisone in the therapy of severe edema].
Topics: Aged; Brain Edema; Drug Synergism; Edema; Female; Humans; Hyperkalemia; Hyponatremia; Metyrapone; Mi | 1968 |
[Diuretics in cirrhosis. Accidents. Indications].
Topics: Adrenal Cortex Hormones; Alkalosis; Blood Urea Nitrogen; Blood Volume; Diuretics; Edema; Ethacrynic | 1969 |
[Saluretic therapy and insulin resistance in diabetes mellitus].
Topics: Aged; Diabetes Complications; Diabetes Mellitus; Diabetic Coma; Female; Furosemide; Humans; Hyponatr | 1966 |