spironolactone has been researched along with Hypomenorrhea in 18 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There are limited data regarding the long-term outcomes of spironolactone use for women with acne and its effect on truncal acne." | 8.02 | Long-term use of spironolactone for acne in women: A case series of 403 patients. ( Barbieri, JS; Choi, JK; Garg, V; James, WD, 2021) |
| "Thirty-five consecutive patients with acne were treated with spironolactone 100 mg/day, 16 days each month for 3 months." | 7.73 | Effects and side-effects of spironolactone therapy in women with acne. ( Gorgulu, A; Piskin, S; Yemisci, A, 2005) |
| "The authors examined the effect of three months' treatment with spironolactone in 34 women with polycystic ovary syndrome." | 7.66 | Therapeutic effects of spironolactone in polycystic ovary syndrome. ( Kirschner, MA; Milewicz, A; Silber, D, 1983) |
| "Spironolactone was equally effective in the treatment of idiopathic hirsutism and of the polycystic ovary syndrome." | 5.27 | Spironolactone in the treatment of idiopathic hirsutism and the polycystic ovary syndrome. ( Burke, CW; Evans, DJ, 1986) |
| "There are limited data regarding the long-term outcomes of spironolactone use for women with acne and its effect on truncal acne." | 4.02 | Long-term use of spironolactone for acne in women: A case series of 403 patients. ( Barbieri, JS; Choi, JK; Garg, V; James, WD, 2021) |
| "Thirty-five consecutive patients with acne were treated with spironolactone 100 mg/day, 16 days each month for 3 months." | 3.73 | Effects and side-effects of spironolactone therapy in women with acne. ( Gorgulu, A; Piskin, S; Yemisci, A, 2005) |
| "Menstrual irregularity is a recognized side effect of spironolactone when used as a treatment for hirsutism in women." | 3.67 | Absence of progestational activity of oral spironolactone. ( Brumsted, JR; Gibson, M; Nakajima, ST; Riddick, DH, 1989) |
| "The use of spironolactone in the treatment of hypertension has been limited by the occurrence of sexual side effects, mainly menstrual disturbances in women and gynaecomastia in men." | 3.67 | Antialdosterones: incidence and prevention of sexual side effects. ( Corvol, P; de Gasparo, M; Jeunemaître, X; Ménard, J; Preiswerk, G; Whitebread, SE, 1989) |
| "A survey of 54 patients taking spironolactone for hirsutes or acne showed that side-effects occurred in 91%; in 80% of patients, these were related to the anti-androgenic mechanism of the drug (menstrual disturbances, and breast enlargement and tenderness)." | 3.67 | Tolerance of spironolactone. ( Cunliffe, WJ; Hughes, BR, 1988) |
| "The authors examined the effect of three months' treatment with spironolactone in 34 women with polycystic ovary syndrome." | 3.66 | Therapeutic effects of spironolactone in polycystic ovary syndrome. ( Kirschner, MA; Milewicz, A; Silber, D, 1983) |
| "Therapy with spironolactone is often associated with estrogenlike side-effects, including impotence and gynecomastia in men and menstrual irregularity in women." | 3.65 | Spironolactone and endocrine dysfunction. ( , 1976) |
| "Spironolactone was equally effective in the treatment of idiopathic hirsutism and of the polycystic ovary syndrome." | 1.27 | Spironolactone in the treatment of idiopathic hirsutism and the polycystic ovary syndrome. ( Burke, CW; Evans, DJ, 1986) |
| "Spironolactone treatment resulted in the improvement or disappearance of acne in 4 of 5 patients who suffered from this ailment." | 1.27 | Spironolactone therapy for hyperandrogenic anovulatory women--clinical and endocrinological study. ( Asai, M; Hanai, K; Ichikawa, Y; Kikkawa, H; Masahashi, T; Mizutani, S; Narita, O; Ohsawa, M; Tomoda, Y; Wu, MC, 1986) |
| "Thirteen anovulatory oligomenorrheic, hyperandrogenic, and normoprolactinemic women were treated with spironolactone (aldactone) throughout six consecutive menstrual cycles in a dosage of 100 to 150 mg/day." | 1.26 | Induction of ovulation with spironolactone (Aldactone) in anovulatory oligomenorrheic and hyperandrogenic women. ( Diamant, YZ; Evron, S; Shapiro, G, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (66.67) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Garg, V | 1 |
| Choi, JK | 1 |
| James, WD | 1 |
| Barbieri, JS | 1 |
| Kulshreshtha, B | 1 |
| Arora, A | 1 |
| Pahuja, I | 1 |
| Sharma, N | 1 |
| Pant, S | 1 |
| Artini, PG | 1 |
| Di Berardino, OM | 1 |
| Simi, G | 1 |
| Papini, F | 1 |
| Ruggiero, M | 1 |
| Monteleone, P | 1 |
| Cela, V | 1 |
| Yemisci, A | 1 |
| Gorgulu, A | 1 |
| Piskin, S | 1 |
| Evron, S | 1 |
| Shapiro, G | 1 |
| Diamant, YZ | 1 |
| Milewicz, A | 1 |
| Silber, D | 1 |
| Kirschner, MA | 1 |
| Molinatti, GM | 1 |
| Dunaif, A | 1 |
| Erenus, M | 1 |
| Prezelj, J | 1 |
| Kocijancic, A | 1 |
| Andolsek, L | 1 |
| Nakajima, ST | 1 |
| Brumsted, JR | 1 |
| Riddick, DH | 1 |
| Gibson, M | 1 |
| de Gasparo, M | 1 |
| Whitebread, SE | 1 |
| Preiswerk, G | 1 |
| Jeunemaître, X | 1 |
| Corvol, P | 1 |
| Ménard, J | 1 |
| Hughes, BR | 1 |
| Cunliffe, WJ | 1 |
| Evans, DJ | 1 |
| Burke, CW | 1 |
| Masahashi, T | 1 |
| Wu, MC | 1 |
| Ohsawa, M | 1 |
| Asai, M | 1 |
| Ichikawa, Y | 1 |
| Hanai, K | 1 |
| Kikkawa, H | 1 |
| Mizutani, S | 1 |
| Narita, O | 1 |
| Tomoda, Y | 1 |
| Givens, JR | 1 |
| Levitt, JI | 1 |
1 review available for spironolactone and Hypomenorrhea
| Article | Year |
|---|---|
Best methods for identification and treatment of PCOS.
Topics: Androgens; Aromatase Inhibitors; Clomiphene; Contraceptives, Oral, Hormonal; Diagnosis, Differential | 2010 |
2 trials available for spironolactone and Hypomenorrhea
| Article | Year |
|---|---|
Efficacy of flutamide versus spironolactone.
Topics: Contraceptives, Oral; Female; Flutamide; Hirsutism; Humans; Incidence; Menstruation Disturbances; Sp | 1995 |
Dexamethasone and spironolactone in the treatment of non-tumorous hyperandrogenism.
Topics: Adolescent; Adult; Androgens; Dexamethasone; Drug Therapy, Combination; Estrogens; Female; Follicle | 1989 |
15 other studies available for spironolactone and Hypomenorrhea
| Article | Year |
|---|---|
Long-term use of spironolactone for acne in women: A case series of 403 patients.
Topics: Acne Vulgaris; Administration, Oral; Adult; Contraceptives, Oral, Combined; Drug Therapy, Combinatio | 2021 |
Menstrual cyclicity post OC withdrawal in PCOS: Use of non-hormonal options.
Topics: Adolescent; Adult; Contraceptives, Oral, Hormonal; Female; Humans; Hypoglycemic Agents; Menstrual Cy | 2016 |
Effects and side-effects of spironolactone therapy in women with acne.
Topics: Acne Vulgaris; Adult; Androgen Receptor Antagonists; Case-Control Studies; Dehydroepiandrosterone Su | 2005 |
Induction of ovulation with spironolactone (Aldactone) in anovulatory oligomenorrheic and hyperandrogenic women.
Topics: 17-Ketosteroids; Androgens; Anovulation; Female; Follicle Stimulating Hormone; Hirsutism; Humans; Lu | 1981 |
Therapeutic effects of spironolactone in polycystic ovary syndrome.
Topics: Adult; Female; Hirsutism; Humans; Menstruation Disturbances; Pituitary Hormones; Polycystic Ovary Sy | 1983 |
[Can the anti-androgenic effect of spironolactone contraindicate its use in pregnancy?].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Female; Fetus; Genitalia, Male; Hirsutism; | 1980 |
Polycystic ovary syndrome.
Topics: Clomiphene; Contraceptives, Oral; Drug Therapy, Combination; Female; Glucocorticoids; Gonadotropin-R | 1994 |
Spironolactone and endocrine dysfunction.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Androgen Antagonists; Animals; Child, Presc | 1976 |
Absence of progestational activity of oral spironolactone.
Topics: Endometrium; Estrogens; Female; Hirsutism; Humans; Menstruation Disturbances; Progesterone; Prolacti | 1989 |
Antialdosterones: incidence and prevention of sexual side effects.
Topics: Blood Pressure; Female; Fludrocortisone; Gynecomastia; Humans; Hypertension; Male; Menstruation Dist | 1989 |
Tolerance of spironolactone.
Topics: Acne Vulgaris; Adult; Androgen Antagonists; Contraceptives, Oral; Drug Tolerance; Female; Hirsutism; | 1988 |
Spironolactone in the treatment of idiopathic hirsutism and the polycystic ovary syndrome.
Topics: Adolescent; Adult; Female; Hirsutism; Humans; Menstruation Disturbances; Middle Aged; Polycystic Ova | 1986 |
Spironolactone therapy for hyperandrogenic anovulatory women--clinical and endocrinological study.
Topics: Adult; Androgens; Anovulation; Estradiol; Female; Humans; Luteinizing Hormone; Menstruation Disturba | 1986 |
Treatment of hirsutism with spironolactone.
Topics: Androgens; Drug Administration Schedule; Female; Hirsutism; Humans; Menstruation Disturbances; Spiro | 1985 |
Spironolactone therapy and amenorrhea.
Topics: Adult; Amenorrhea; Female; Humans; Kidney Diseases; Menstruation Disturbances; Spironolactone | 1970 |