spironolactone has been researched along with Hypogonadism in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Hypogonadism: Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The recent introduction of a novel, long-acting testosterone formulation (testosterone undecanoate) which only requires one intramuscular injection every 3 months, together with the already available hydroalcoholic testosterone gels, appear to be promising alternatives to the previous standard substitution therapy for male hypogonadism." | 4.83 | [The latest developments in endocrinology 2004/2005]. ( Fottner, C; Weber, MM, 2006) |
| "Spironolactone (Aldactone) acts as an antiandrogen by blocking testosterone synthesis and competing with testosterone for the androgen receptor." | 1.26 | Spironolactone stimulation of gonadotropin secretion in boys with delayed adolescence. ( Friend, J; Kulin, HE; Loriaux, DL; Santen, RJ, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fottner, C | 1 |
| Weber, MM | 1 |
| Kley, HK | 1 |
| Santen, RJ | 1 |
| Kulin, HE | 1 |
| Loriaux, DL | 1 |
| Friend, J | 1 |
| Potter, C | 1 |
| Willis, D | 1 |
| Sharp, HL | 1 |
| Scharzenberg, SJ | 1 |
1 review available for spironolactone and Hypogonadism
| Article | Year |
|---|---|
[The latest developments in endocrinology 2004/2005].
Topics: Adrenal Gland Neoplasms; Adult; Bone Density Conservation Agents; Chronic Kidney Disease-Mineral and | 2006 |
3 other studies available for spironolactone and Hypogonadism
| Article | Year |
|---|---|
[Diagnostic procedures in gynecomastia].
Topics: Adolescent; Adult; Diagnosis, Differential; Digitalis; Estradiol Congeners; Gynecomastia; Humans; Hy | 1984 |
Spironolactone stimulation of gonadotropin secretion in boys with delayed adolescence.
Topics: Adolescent; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Hypogonadism; Male; Puberty; | 1976 |
Primary and secondary amenorrhea associated with spironolactone therapy in chronic liver disease.
Topics: Adolescent; Adult; Amenorrhea; Cholestasis; Chronic Disease; Female; Humans; Hypertension, Portal; H | 1992 |