spironolactone has been researched along with Hypoglycemia in 6 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A total of 6,496 patients from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) were categorized into 4 groups by plasma glucose concentration: ≤4." | 5.16 | Hypo- and hyperglycemia predict outcome in patients with left ventricular dysfunction after acute myocardial infarction: data from EPHESUS. ( Böhm, M; Dobre, D; Kindermann, I; Lamiral, Z; Mahfoud, F; Pitt, B; Rossignol, P; Tala, S; Turgonyi, E; Ukena, C; Zannad, F, 2012) |
| " The following experiments were performed: I) A relationship was observed between the amount of insulin dosage and the levels of serum potassium, blood sugar, and plasma cyclic AMP or plasma cyclic GMP in normal controls and rats." | 1.26 | [The mechanism of the decrease in serum potassium during insulin-induced hypoglycemia (author's transl)]. ( Aikawa, T, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Man, JJ | 1 |
| Lu, Q | 1 |
| Moss, ME | 1 |
| Carvajal, B | 1 |
| Baur, W | 1 |
| Garza, AE | 1 |
| Freeman, R | 1 |
| Anastasiou, M | 1 |
| Ngwenyama, N | 1 |
| Adler, GK | 1 |
| Alcaide, P | 1 |
| Jaffe, IZ | 1 |
| Osborne, DM | 1 |
| O'Leary, KE | 1 |
| Fitzgerald, DP | 1 |
| George, AJ | 1 |
| Vidal, MM | 1 |
| Anderson, BM | 1 |
| McNay, EC | 1 |
| Ukena, C | 1 |
| Dobre, D | 1 |
| Mahfoud, F | 1 |
| Kindermann, I | 1 |
| Lamiral, Z | 1 |
| Tala, S | 1 |
| Rossignol, P | 1 |
| Turgonyi, E | 1 |
| Pitt, B | 1 |
| Böhm, M | 1 |
| Zannad, F | 1 |
| Hoff, F | 1 |
| Aikawa, T | 1 |
| Weille, FL | 1 |
1 trial available for spironolactone and Hypoglycemia
| Article | Year |
|---|---|
Hypo- and hyperglycemia predict outcome in patients with left ventricular dysfunction after acute myocardial infarction: data from EPHESUS.
Topics: Aged; Blood Glucose; Diabetes Complications; Double-Blind Method; Eplerenone; Female; Humans; Hyperg | 2012 |
5 other studies available for spironolactone and Hypoglycemia
| Article | Year |
|---|---|
Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis.
Topics: Adult; Animals; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Cell Adhesion; Disease Models, An | 2021 |
Context-dependent memory following recurrent hypoglycaemia in non-diabetic rats is mediated via glucocorticoid signalling in the dorsal hippocampus.
Topics: Animals; Corticosterone; Glucocorticoids; Hippocampus; Hypoglycemia; Male; Mifepristone; Rats; Rats, | 2017 |
[Instinctive food selection as a disease-regulating factor].
Topics: Appetite; Autonomic Nervous System; Disease; Female; Food; Humans; Hunger; Hyperaldosteronism; Hypoc | 1966 |
[The mechanism of the decrease in serum potassium during insulin-induced hypoglycemia (author's transl)].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Animals; Blood Glucose; Cyclic AMP; Dose-Respo | 1982 |
Hypoglycemia in Meniere's disease.
Topics: Adrenocorticotropic Hormone; Aldosterone; Desoxycorticosterone; Diet Therapy; Dietary Carbohydrates; | 1968 |