spironolactone has been researched along with Hypertension, Essential in 7 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the effects of eplerenone monotherapy versus placebo for primary hypertension in adults." | 8.95 | Eplerenone for hypertension. ( Kinkade, A; Masson, SC; Stabler, SN; Tam, TS; Tejani, AM; Tsang, MP; Tung, A; Wu, MH, 2017) |
| "Eplerenone is a selective mineralocorticoid receptor antagonist; however, little is known about its effects on insulin action." | 6.79 | Effect of eplerenone on insulin action in essential hypertension: a randomised, controlled, crossover study. ( Atkinson, AB; Bell, PM; Ennis, C; Hunter, SJ; McMurray, EM; Wallace, IR, 2014) |
| "The incidence of left ventricular hypertrophy (LVH) in primary aldosteronism (PA) is higher than in essential hypertension." | 5.39 | Regression of left ventricular hypertrophy in patients with primary aldosteronism/low-renin hypertension on low-dose spironolactone. ( Bergman, M; Chagnac, A; Gafter, U; Herman-Edelstein, M; Korzets, A; Ori, Y; Salman, H; Zingerman, B, 2013) |
| "To assess the effects of eplerenone monotherapy versus placebo for primary hypertension in adults." | 4.95 | Eplerenone for hypertension. ( Kinkade, A; Masson, SC; Stabler, SN; Tam, TS; Tejani, AM; Tsang, MP; Tung, A; Wu, MH, 2017) |
| "Eplerenone is a selective mineralocorticoid receptor antagonist; however, little is known about its effects on insulin action." | 2.79 | Effect of eplerenone on insulin action in essential hypertension: a randomised, controlled, crossover study. ( Atkinson, AB; Bell, PM; Ennis, C; Hunter, SJ; McMurray, EM; Wallace, IR, 2014) |
| "The incidence of left ventricular hypertrophy (LVH) in primary aldosteronism (PA) is higher than in essential hypertension." | 1.39 | Regression of left ventricular hypertrophy in patients with primary aldosteronism/low-renin hypertension on low-dose spironolactone. ( Bergman, M; Chagnac, A; Gafter, U; Herman-Edelstein, M; Korzets, A; Ori, Y; Salman, H; Zingerman, B, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lorthioir, A | 1 |
| Belmihoub, I | 1 |
| Fouassier, D | 1 |
| Azizi, M | 1 |
| Amar, L | 1 |
| Funder, JW | 1 |
| McMurray, EM | 1 |
| Wallace, IR | 1 |
| Ennis, C | 1 |
| Hunter, SJ | 1 |
| Atkinson, AB | 1 |
| Bell, PM | 1 |
| Tam, TS | 1 |
| Wu, MH | 1 |
| Masson, SC | 1 |
| Tsang, MP | 1 |
| Stabler, SN | 1 |
| Kinkade, A | 1 |
| Tung, A | 1 |
| Tejani, AM | 1 |
| Ori, Y | 1 |
| Chagnac, A | 1 |
| Korzets, A | 1 |
| Zingerman, B | 1 |
| Herman-Edelstein, M | 1 |
| Bergman, M | 1 |
| Gafter, U | 1 |
| Salman, H | 1 |
| MIZGALA, HF | 1 |
| SCHAEFER, HE | 1 |
| WOELFER, HJ | 1 |
| SCHNEIDER, KW | 1 |
3 reviews available for spironolactone and Hypertension, Essential
| Article | Year |
|---|---|
[Spironolactone in resistant essential hypertension].
Topics: Antihypertensive Agents; Blood Pressure; Drug Resistance; Drug Therapy, Combination; Essential Hyper | 2019 |
Eplerenone for hypertension.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Eplerenone; Essential Hypertension; Female; Humans; | 2017 |
NEWER DRUGS IN THE TREATMENT OF HYPERTENSION.
Topics: Antihypertensive Agents; Bretylium Compounds; Chlorothiazide; Chlorthalidone; Diuretics; Drug Therap | 1965 |
1 trial available for spironolactone and Hypertension, Essential
| Article | Year |
|---|---|
Effect of eplerenone on insulin action in essential hypertension: a randomised, controlled, crossover study.
Topics: Blood Glucose; Cross-Over Studies; Double-Blind Method; Eplerenone; Essential Hypertension; Female; | 2014 |
3 other studies available for spironolactone and Hypertension, Essential
| Article | Year |
|---|---|
Primary aldosteronism and low-renin hypertension: a continuum?
Topics: Essential Hypertension; Female; Humans; Hyperaldosteronism; Hypertension; Hypertrophy, Left Ventricu | 2013 |
Regression of left ventricular hypertrophy in patients with primary aldosteronism/low-renin hypertension on low-dose spironolactone.
Topics: Aged; Blood Pressure Determination; Echocardiography; Essential Hypertension; Female; Follow-Up Stud | 2013 |
[Contribution to the treatment of essential hypertension.(Control of blood pressure, active blood volume, venous pressure, circulation time and mineral metabolism after Repicin and spirolactone medication)].
Topics: Aldosterone; Blood Circulation Time; Blood Pressure; Blood Pressure Determination; Blood Volume; Chl | 1962 |