spironolactone has been researched along with Hypernatremia in 9 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Hypernatremia: Excessive amount of sodium in the blood. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spironolactone is an aldosterone antagonist that promotes natriuresis and may attenuate such hypernatraemia, but its effect in this setting has not been previously studied." | 2.73 | Pilot randomised double-blind controlled trial of high-dose spironolactone in critically ill patients receiving a frusemide infusion. ( Apte, Y; Bellomo, R; Gillies, M; Goldsmith, D; McGain, F; Warrillow, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Apte, Y | 1 |
| Bellomo, R | 1 |
| Warrillow, S | 1 |
| Goldsmith, D | 1 |
| Gillies, M | 1 |
| McGain, F | 1 |
| CATTANEO, G | 1 |
| DE LUCA, S | 1 |
| CENANI, A | 1 |
| FRIEDERISZICK, FK | 1 |
| CAVELL, B | 1 |
| HOEKFELT, B | 1 |
| Greenberg, A | 1 |
| Reimold, EW | 1 |
| Sridhar, CB | 1 |
| Calvert, GD | 1 |
| Ibbertson, HK | 1 |
| Eriksson, I | 1 |
| Sawyer, RB | 1 |
| Spencer, JR | 1 |
| Dudzinski, PJ | 1 |
| Enis, JE | 1 |
1 trial available for spironolactone and Hypernatremia
| Article | Year |
|---|---|
Pilot randomised double-blind controlled trial of high-dose spironolactone in critically ill patients receiving a frusemide infusion.
Topics: Aged; Critical Care; Critical Illness; Diuretics; Double-Blind Method; Female; Furosemide; Humans; H | 2008 |
8 other studies available for spironolactone and Hypernatremia
| Article | Year |
|---|---|
[On the use of spironolactone in water and salt retention in pregnancy toxemia].
Topics: Female; Humans; Hypernatremia; Natriuresis; Pre-Eclampsia; Pregnancy; Spironolactone; Toxemia; Water | 1962 |
[FAMILIAL RENAL DIABETES INSIPIDUS. II].
Topics: Blood Chemical Analysis; Chlorides; Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Diagnosis; H | 1963 |
PRIMARY ALDOSTERONISM DUE TO AN ADRENAL ADENOMA IN A THREE-YEAR-OLD CHILD.
Topics: 17-Ketosteroids; Adenoma; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenocortical Adenoma; | 1964 |
What's new in diuretic therapy.
Topics: Acetazolamide; Acid-Base Imbalance; Biological Transport; Diuretics; Drug Resistance; Ethacrynic Aci | 1986 |
[Angiotensin and saluretics in nephrogenic diabetes insipidus of early infancy].
Topics: Angiotensin II; Body Temperature; Chlorthalidone; Diabetes Insipidus; Electrolytes; Female; Furosemi | 1967 |
Syndrome of hypernatremia, hypodipsia and partial diabetes insipidus: a new interpretation.
Topics: Adolescent; Chlorpropamide; Diabetes Insipidus; Drinking; Female; Humans; Hydrochlorothiazide; Hyper | 1974 |
Severe hypernatremia complicating heart valve surgery. A preliminary report.
Topics: Aortic Valve; Aortic Valve Stenosis; Body Weight; Chlorides; Heart Failure; Heart Valve Prosthesis; | 1969 |
Hypernatremia with pharmacologic doses of steroids.
Topics: Aged; Female; Humans; Hydrocortisone; Hypernatremia; Male; Methylprednisolone; Middle Aged; Pituitar | 1967 |