spironolactone has been researched along with Hyperglycemia in 17 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin (an insulin sensitizer) and spironolactone (an antiandrogen) are both used for treatment of polycystic ovary syndrome." | 7.78 | Effect of metformin and spironolactone therapy on OGTT in patients with polycystic ovarian syndrome - a retrospective analysis. ( Ammini, AC; Ganie, MA; Gupta, N; Kulshreshtha, B, 2012) |
| "A total of 6,496 patients from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) were categorized into 4 groups by plasma glucose concentration: ≤4." | 5.16 | Hypo- and hyperglycemia predict outcome in patients with left ventricular dysfunction after acute myocardial infarction: data from EPHESUS. ( Böhm, M; Dobre, D; Kindermann, I; Lamiral, Z; Mahfoud, F; Pitt, B; Rossignol, P; Tala, S; Turgonyi, E; Ukena, C; Zannad, F, 2012) |
| "Metformin (an insulin sensitizer) and spironolactone (an antiandrogen) are both used for treatment of polycystic ovary syndrome." | 3.78 | Effect of metformin and spironolactone therapy on OGTT in patients with polycystic ovarian syndrome - a retrospective analysis. ( Ammini, AC; Ganie, MA; Gupta, N; Kulshreshtha, B, 2012) |
| "Type 1 diabetes was induced in female Wistar rats by a single tail vein injection of streptozotocin (STZ), and SPL was administrated daily by gavage, from days 3-21." | 1.46 | Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats. ( González-Ramírez, R; Molina-Jijón, E; Namorado-Tónix, C; Pedraza-Chaverri, J; Reyes, JL; Rodríguez-Muñoz, R, 2017) |
| "Aldosterone plays a crucial role in cardiovascular disease." | 1.39 | Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity. ( Berger, S; Lohmann, C; Lüscher, TF; Matter, CM; Miranda, MX; Nussberger, J; Ruschitzka, F; Schäfer, N; van Tits, LJ; Vergopoulos, A; Verrey, F; Winnik, S, 2013) |
| "The spironolactone treatment group had significantly reduced IL-6 and TNF-alpha expression compared with the high glucose group." | 1.36 | [Effect of spironolactone on the expression of Toll-like receptor 4 in renal tubular epithelia cells exposed to high glucose]. ( Ao, X; Bao, RL; Hong, XM; Liu, KH; Tang, TF; Zhou, QL, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (52.94) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ebadi, Z | 1 |
| Moradi, N | 1 |
| Kazemi Fard, T | 1 |
| Balochnejadmojarrad, T | 1 |
| Chamani, E | 1 |
| Fadaei, R | 1 |
| Fallah, S | 1 |
| Molina-Jijón, E | 1 |
| Rodríguez-Muñoz, R | 1 |
| González-Ramírez, R | 1 |
| Namorado-Tónix, C | 1 |
| Pedraza-Chaverri, J | 1 |
| Reyes, JL | 1 |
| Schäfer, N | 1 |
| Lohmann, C | 1 |
| Winnik, S | 1 |
| van Tits, LJ | 1 |
| Miranda, MX | 1 |
| Vergopoulos, A | 1 |
| Ruschitzka, F | 1 |
| Nussberger, J | 1 |
| Berger, S | 1 |
| Lüscher, TF | 1 |
| Verrey, F | 1 |
| Matter, CM | 1 |
| Liu, KH | 1 |
| Zhou, QL | 1 |
| Ao, X | 1 |
| Tang, TF | 1 |
| Hong, XM | 1 |
| Bao, RL | 1 |
| Toyonaga, J | 1 |
| Tsuruya, K | 1 |
| Ikeda, H | 1 |
| Noguchi, H | 1 |
| Yotsueda, H | 1 |
| Fujisaki, K | 1 |
| Hirakawa, M | 1 |
| Taniguchi, M | 1 |
| Masutani, K | 1 |
| Iida, M | 1 |
| Lian, M | 1 |
| Hewitson, TD | 1 |
| Wigg, B | 1 |
| Samuel, CS | 1 |
| Chow, F | 1 |
| Becker, GJ | 1 |
| Kulshreshtha, B | 1 |
| Gupta, N | 1 |
| Ganie, MA | 1 |
| Ammini, AC | 1 |
| Ukena, C | 1 |
| Dobre, D | 1 |
| Mahfoud, F | 1 |
| Kindermann, I | 1 |
| Lamiral, Z | 1 |
| Tala, S | 1 |
| Rossignol, P | 1 |
| Turgonyi, E | 1 |
| Pitt, B | 1 |
| Böhm, M | 1 |
| Zannad, F | 1 |
| Foy, JM | 1 |
| Marone, C | 1 |
| Beretta-Piccoli, C | 1 |
| Weidmann, P | 1 |
| Cannon, ML | 1 |
| Tannenbaum, RP | 1 |
| La Franco, M | 1 |
| Gifford, RW | 1 |
| Sitt, R | 1 |
| Senft, G | 1 |
| Losert, W | 1 |
| Kaess, H | 1 |
| Hori, S | 2 |
| Masumura, S | 2 |
| Ono, K | 2 |
| Sato, Y | 1 |
| Leiter, L | 1 |
| Reubi, FC | 1 |
2 reviews available for spironolactone and Hyperglycemia
| Article | Year |
|---|---|
Combinations of diuretics in the treatment of edema.
Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Edema; Ethacrynic Acid; Furosemide; Glu | 1970 |
Combination diuretic drug therapy.
Topics: Amiloride; Benzothiadiazines; Diet; Diuretics; Drug Therapy, Combination; Ethacrynic Acid; Furosemid | 1971 |
1 trial available for spironolactone and Hyperglycemia
| Article | Year |
|---|---|
Hypo- and hyperglycemia predict outcome in patients with left ventricular dysfunction after acute myocardial infarction: data from EPHESUS.
Topics: Aged; Blood Glucose; Diabetes Complications; Double-Blind Method; Eplerenone; Female; Humans; Hyperg | 2012 |
14 other studies available for spironolactone and Hyperglycemia
| Article | Year |
|---|---|
Captopril and Spironolactone Can Attenuate Diabetic Nephropathy in Wistar Rats by Targeting microRNA-192 and microRNA-29a/b/c.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Blood Urea Nitrogen; Captopril; Creatinine; Diabete | 2019 |
Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats.
Topics: Aldosterone; Animals; Claudin-4; Claudins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2017 |
Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity.
Topics: Adipose Tissue; Aldosterone; Animals; Antioxidants; Aorta; Cyclooxygenase 1; Cyclooxygenase Inhibito | 2013 |
[Effect of spironolactone on the expression of Toll-like receptor 4 in renal tubular epithelia cells exposed to high glucose].
Topics: Cells, Cultured; Diabetic Nephropathies; Epithelial Cells; Humans; Hyperglycemia; Immunohistochemist | 2010 |
Spironolactone inhibits hyperglycemia-induced podocyte injury by attenuating ROS production.
Topics: Animals; Blotting, Western; Diabetes Mellitus, Experimental; Hyperglycemia; Male; Mineralocorticoid | 2011 |
Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease.
Topics: Aldosterone; Animals; Blood Pressure; Blotting, Western; Collagen Type IV; Diabetes Mellitus, Experi | 2012 |
Effect of metformin and spironolactone therapy on OGTT in patients with polycystic ovarian syndrome - a retrospective analysis.
Topics: Adolescent; Adult; Androgen Antagonists; Female; Glucose Intolerance; Hirsutism; Humans; Hyperglycem | 2012 |
Acute diuretic induced hyperglycaemia in rats.
Topics: Acetazolamide; Adrenalectomy; Animals; Bendroflumethiazide; Chlorthalidone; Ergotamine; Ethacrynic A | 1967 |
[Basis and clinical aspects of diuretic drug therapy].
Topics: Acetazolamide; Benzothiadiazines; Diuretics; Edema; Edema, Cardiac; Furosemide; Glaucoma; Humans; Hy | 1979 |
Diuretics in the treatment of hypertension.
Topics: Benzothiadiazines; Diuretics; Humans; Hyperglycemia; Hypertension; Hypokalemia; Sodium Chloride Symp | 1978 |
A guide to the practical use of diuretics.
Topics: Administration, Oral; Diuretics; Edema; Furosemide; Humans; Hypercalcemia; Hyperglycemia; Hypertensi | 1976 |
[The effect of hydrochlorthiazide on the blood sugar-increasing action of diazoxide].
Topics: Animals; Antihypertensive Agents; Carbohydrate Metabolism; Diazoxide; Hydrochlorothiazide; Hyperglyc | 1966 |
Effect of aldosterone on angiotensin-induced glycosuria.
Topics: Aldosterone; Angiotensin II; Animals; Glycosuria; Hyperglycemia; Injections, Intravenous; Rabbits; R | 1969 |
Mechanism of angiotensin-induce glycosuria.
Topics: Aldosterone; Angiotensin II; Animals; Blood Glucose; Epinephrine; Glycosuria; Hyperglycemia; Injecti | 1969 |