spironolactone has been researched along with Hepatorenal Syndrome in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Hepatorenal Syndrome: Functional KIDNEY FAILURE in patients with liver disease, usually LIVER CIRRHOSIS or portal hypertension (HYPERTENSION, PORTAL), and in the absence of intrinsic renal disease or kidney abnormality. It is characterized by intense renal vasculature constriction, reduced renal blood flow, OLIGURIA, and sodium retention.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Portal hypertension is one of the main consequences of cirrhosis." | 2.43 | Current management of the complications of portal hypertension: variceal bleeding and ascites. ( Calès, P; Dib, N; Oberti, F, 2006) |
| " Minimum effective dosage is recommented to reduce side-effects." | 1.35 | [Ascites]. ( Maier, KP, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maier, KP | 1 |
| Kalambokis, G | 1 |
| Tsianos, EV | 1 |
| Dib, N | 1 |
| Oberti, F | 1 |
| Calès, P | 1 |
| Arroyo, V | 1 |
| Badalamenti, S | 1 |
| Ginès, P | 1 |
1 review available for spironolactone and Hepatorenal Syndrome
| Article | Year |
|---|---|
Current management of the complications of portal hypertension: variceal bleeding and ascites.
Topics: Algorithms; Anti-Bacterial Agents; Ascites; Collateral Circulation; Diuretics; Endoscopy, Gastrointe | 2006 |
3 other studies available for spironolactone and Hepatorenal Syndrome
| Article | Year |
|---|---|
[Ascites].
Topics: Algorithms; Ascites; Diagnosis, Differential; Diet, Sodium-Restricted; Hepatorenal Syndrome; Humans; | 2008 |
Refractory ascites: can it be defined only by the response to furosemide and spironolactone?
Topics: Ascites; Diuretics; Furosemide; Glomerular Filtration Rate; Hepatorenal Syndrome; Humans; Liver Cirr | 2010 |
Refractory ascites: definition and mechanism.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ascites; Diet, Sodium-Restricted; Diuretics; Drainage; Drug | 1987 |