spironolactone has been researched along with Hepatic Encephalopathy in 19 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Patients without hyperkalemia were administrated 100 mg of spironolactone/day." | 9.22 | High Dose Oral Furosemide with Salt Ingestion in the Treatment of Refractory Ascites of Liver Cirrhosis. ( Demir, M; Dogan, O; Ozer, B; Parlakgumus, A; Serin, E; Yakar, T, 2016) |
| "The aim of this study was to specify the mechanism of hepatic encephalopathy which may occur in some cirrhotics treated by Spironolactone." | 7.65 | [Hyperammonemia and hepatic encephalopathy in cirrhotics receiving spironolactone (author's transl)]. ( Imler, M; Schlienger, JL, 1977) |
| "Spironolactone is an aldosterone receptor antagonist used to control fluid overload in cirrhotic patients although recent studies suggest that it also inhibits angiogenesis." | 5.42 | The Impact of Spironolactone on the Severity of Portal-Systemic Collaterals and Hepatic Encephalopathy in Cirrhotic Rats. ( Chang, CC; Ho, HL; Hsin, IF; Hsu, SJ; Huang, HC; Huo, TI; Lee, FY; Lee, SD; Lin, HC; Wang, SS, 2015) |
| " Patients without hyperkalemia were administrated 100 mg of spironolactone/day." | 5.22 | High Dose Oral Furosemide with Salt Ingestion in the Treatment of Refractory Ascites of Liver Cirrhosis. ( Demir, M; Dogan, O; Ozer, B; Parlakgumus, A; Serin, E; Yakar, T, 2016) |
| "To compare the efficacy of three commonly used diuretic regimens in the treatment of ascites, we randomized 90 patients to three treatment groups: Sequential Spironolactone (spironolactone followed by furosemide if necessary), Combination (spironolactone and furosemide in combination), and Furosemide (furosemide given alone)." | 5.05 | Diuresis in the ascitic patient: a randomized controlled trial of three regimens. ( Fogel, MR; Gregory, PB; Knauer, CM; Miller, RG; Neal, EA; Sawhney, VK, 1981) |
| "The aim of this study was to specify the mechanism of hepatic encephalopathy which may occur in some cirrhotics treated by Spironolactone." | 3.65 | [Hyperammonemia and hepatic encephalopathy in cirrhotics receiving spironolactone (author's transl)]. ( Imler, M; Schlienger, JL, 1977) |
| "In 8 out of 20 patients with chronic liver disease ascites was controlled with metolazone, 10 required additional amiloride or spironolactone to achieve control, and 2 were resistant to all diuretic therapy." | 3.65 | Use of metolazone in the treatment of ascites due to liver disease. ( Hillenbrand, P; Sherlock, S, 1971) |
| "Ascites, variceal bleeding, hepatic encephalopathy, and hepatorenal syndrome are among the complications you are likely to encounter when caring for a patient with cirrhosis." | 1.42 | Cirrhosis complications: keeping them under control. ( Eliacin, I; Kashan, S; Minor, SE; Whisenant, EB, 2015) |
| "Spironolactone is an aldosterone receptor antagonist used to control fluid overload in cirrhotic patients although recent studies suggest that it also inhibits angiogenesis." | 1.42 | The Impact of Spironolactone on the Severity of Portal-Systemic Collaterals and Hepatic Encephalopathy in Cirrhotic Rats. ( Chang, CC; Ho, HL; Hsin, IF; Hsu, SJ; Huang, HC; Huo, TI; Lee, FY; Lee, SD; Lin, HC; Wang, SS, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (84.21) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Minor, SE | 1 |
| Eliacin, I | 1 |
| Kashan, S | 1 |
| Whisenant, EB | 1 |
| Hsu, SJ | 1 |
| Wang, SS | 1 |
| Huo, TI | 1 |
| Lee, FY | 1 |
| Huang, HC | 1 |
| Chang, CC | 1 |
| Hsin, IF | 1 |
| Ho, HL | 1 |
| Lin, HC | 1 |
| Lee, SD | 1 |
| Yakar, T | 1 |
| Demir, M | 1 |
| Dogan, O | 1 |
| Parlakgumus, A | 1 |
| Ozer, B | 1 |
| Serin, E | 1 |
| STERNBERG, MS | 1 |
| HAGEDORN, CW | 1 |
| KALSER, MH | 1 |
| BAGROS, P | 1 |
| Pisi, E | 1 |
| Marchesini, G | 1 |
| Fogel, MR | 1 |
| Sawhney, VK | 1 |
| Neal, EA | 1 |
| Miller, RG | 1 |
| Knauer, CM | 1 |
| Gregory, PB | 1 |
| Di Constanzo, J | 1 |
| Cano, N | 1 |
| Sarrat, P | 1 |
| Millet, Y | 1 |
| Gauthier, A | 1 |
| Bossone, CM | 1 |
| Imler, M | 1 |
| Schlienger, JL | 1 |
| Sherlock, S | 3 |
| Senewiratne, B | 2 |
| Scott, A | 2 |
| Walker, JG | 2 |
| Inberg, MV | 1 |
| Harjola, PT | 1 |
| Scheinin, TM | 1 |
| Ilinich, VK | 1 |
| Plastun, FF | 1 |
| Leemhuis, MP | 1 |
| Struyvenberg, A | 1 |
| Kommerell, B | 2 |
| Leiter, L | 1 |
| Hillenbrand, P | 1 |
3 reviews available for spironolactone and Hepatic Encephalopathy
| Article | Year |
|---|---|
[Treatment of acute hepatic insufficiency (a survey of the literature)].
Topics: Acute Disease; Adenosine Triphosphate; Arginine; Chemical and Drug Induced Liver Injury; Exchange Tr | 1972 |
Significance of hypokalaemia due to diuretics.
Topics: Amiloride; Arrhythmias, Cardiac; Chlorothiazide; Diuretics; Ethacrynic Acid; Extracellular Space; Fu | 1973 |
Combinations of diuretics in the treatment of edema.
Topics: Acetazolamide; Benzothiadiazines; Chlorthalidone; Diuretics; Edema; Ethacrynic Acid; Furosemide; Glu | 1970 |
2 trials available for spironolactone and Hepatic Encephalopathy
| Article | Year |
|---|---|
High Dose Oral Furosemide with Salt Ingestion in the Treatment of Refractory Ascites of Liver Cirrhosis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Albumins; Ascites; Bilirubin; Creatinine; End | 2016 |
Diuresis in the ascitic patient: a randomized controlled trial of three regimens.
Topics: Ascites; Body Weight; Clinical Trials as Topic; Drug Therapy, Combination; Female; Furosemide; Hepat | 1981 |
14 other studies available for spironolactone and Hepatic Encephalopathy
| Article | Year |
|---|---|
Cirrhosis complications: keeping them under control.
Topics: Antihypertensive Agents; Ascites; Diuretics; Furosemide; Hemorrhage; Hepatic Encephalopathy; Humans; | 2015 |
The Impact of Spironolactone on the Severity of Portal-Systemic Collaterals and Hepatic Encephalopathy in Cirrhotic Rats.
Topics: Ammonia; Animals; Bile Ducts; Body Weight; Hemodynamics; Hepatic Encephalopathy; Kidney; Ligation; L | 2015 |
THE USE OF SPIRONOLACTONE AND LARGE DOSES OF STEROIDS IN THE TREATMENT OF ASCITES OF LIVER DISEASE.
Topics: Adrenal Cortex Hormones; Ascites; Chlorothiazide; Diuresis; Hepatic Encephalopathy; Humans; Hyponatr | 1963 |
[THE TREATMENT OF EDEMA WITH SULFONAMIDE DIURETICS].
Topics: Acetazolamide; Acidosis; Benzothiadiazines; Chlorothiazide; Chlorthalidone; Dehydration; Diuretics; | 1964 |
[Hepatic coma. Therapeutic aspects].
Topics: Amino Acids; Bromocriptine; Electrolytes; Furosemide; Glucose; Hepatic Encephalopathy; Histamine H2 | 1984 |
[Letter: The treatment of brain edema during hepatic coma].
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Brain Edema; Female; Hepatic Encephalopathy; Hepatit | 1975 |
The liver: a pharmacologic perspective.
Topics: Acetaldehyde; Alcoholism; Chemical and Drug Induced Liver Injury; Diuretics; Drug-Related Side Effec | 1977 |
[Hyperammonemia and hepatic encephalopathy in cirrhotics receiving spironolactone (author's transl)].
Topics: Adult; Aged; Ammonia; Hepatic Encephalopathy; Humans; Intestinal Mucosa; Liver Cirrhosis; Male; Midd | 1977 |
Complications of diuretic therapy in hepatic cirrhosis.
Topics: Chlorothiazide; Diuretics; Ethacrynic Acid; Furosemide; Hepatic Encephalopathy; Humans; Hypokalemia; | 1966 |
Role of the mesentericocaval shunt in the management of portal hypertension.
Topics: Adolescent; Adult; Diuretics; Duodenal Ulcer; Edema; Female; Follow-Up Studies; Gastrointestinal Hem | 1974 |
[Therapy of liver cirrhosis].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Diet, Sodium-Restricted; Esophageal and Gastric V | 1972 |
Use of metolazone in the treatment of ascites due to liver disease.
Topics: Adult; Ascites; Chlorides; Chronic Disease; Diuretics; Female; Hepatic Encephalopathy; Humans; Hypok | 1971 |
The complications of diuretic therapy in patients with cirrhosis.
Topics: Alkalosis; Ascites; Blood Urea Nitrogen; Chlorothiazide; Ethacrynic Acid; Furosemide; Hepatic Enceph | 1966 |
[Therapy of liver cirrhosis].
Topics: Adrenal Cortex Hormones; Anabolic Agents; Diet Therapy; Hepatic Encephalopathy; Humans; Hypertension | 1971 |