spironolactone has been researched along with Hemorrhage, Peptic Ulcer in 2 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The risk of gastroduodenal ulcers or upper gastrointestinal bleeding is significantly increased in patients using spironolactone." | 3.73 | Spironolactone and risk of upper gastrointestinal events: population based case-control study. ( Dieleman, J; Mosis, G; Stricker, B; Sturkenboom, M; Verhamme, K, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Verhamme, K | 1 |
| Mosis, G | 1 |
| Dieleman, J | 1 |
| Stricker, B | 1 |
| Sturkenboom, M | 1 |
| Mackay, A | 1 |
| Stevenson, RD | 1 |
2 other studies available for spironolactone and Hemorrhage, Peptic Ulcer
| Article | Year |
|---|---|
Spironolactone and risk of upper gastrointestinal events: population based case-control study.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Diuretics; Duodenal Ulcer; Female; Humans; Male; Midd | 2006 |
Gastric ulceration induced by spironolactone.
Topics: Ascites; Female; Hematemesis; Humans; Middle Aged; Peptic Ulcer Hemorrhage; Spironolactone; Stomach | 1977 |