spironolactone has been researched along with Hearing Loss, Sensorineural in 2 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Hearing Loss, Sensorineural: Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The spironolactone treatment did not block normal glucocorticoid receptor-mediated immune-suppression functions because mice receiving prednisolone, either with or without spironolactone, maintained normal body weights, hematocrits, and serum immune complexes." | 1.33 | Mineralocorticoid receptor mediates glucocorticoid treatment effects in the autoimmune mouse ear. ( Gross, ND; Kempton, JB; Trune, DR, 2006) |
| "Although autoimmune sensorineural hearing loss can be effectively treated with corticosteroids, little is known about how these drugs affect cochlear function." | 1.31 | Spironolactone blocks glucocorticoid-mediated hearing preservation in autoimmune mice. ( Gross, ND; Kempton, JB; Trune, DR, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trune, DR | 2 |
| Kempton, JB | 2 |
| Gross, ND | 2 |
2 other studies available for spironolactone and Hearing Loss, Sensorineural
| Article | Year |
|---|---|
Mineralocorticoid receptor mediates glucocorticoid treatment effects in the autoimmune mouse ear.
Topics: Aldosterone; Animals; Antigen-Antibody Complex; Auditory Threshold; Autoimmune Diseases; Body Weight | 2006 |
Spironolactone blocks glucocorticoid-mediated hearing preservation in autoimmune mice.
Topics: Aldosterone; Animals; Audiometry, Pure-Tone; Auditory Threshold; Disease Models, Animal; Drug Intera | 2002 |