spironolactone has been researched along with Glomerulonephritis in 23 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Glomerulonephritis: Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " After 4 weeks of DOCA-salt hypertension, rats were either killed (n = 6), or treated with a non-hypotensive dose of spironolactone (n = 7) or triple therapy (hydrochlorothiazide, reserpine and hydralazine, n = 8) to normalize blood pressure or with vehicle (n = 19) for two further weeks." | 3.74 | Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension. ( Cordasic, N; Hartner, A; Hilgers, KF; Klanke, B; Schmieder, RE; Veelken, R, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (73.91) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, JJ | 1 |
| Chen, YP | 1 |
| Yang, M | 1 |
| Liu, BL | 1 |
| Dong, J | 1 |
| Dong, HR | 1 |
| Rui, HL | 1 |
| Cheng, H | 1 |
| Klanke, B | 1 |
| Cordasic, N | 1 |
| Hartner, A | 1 |
| Schmieder, RE | 1 |
| Veelken, R | 1 |
| Hilgers, KF | 1 |
| Bianchi, S | 1 |
| Bigazzi, R | 1 |
| Campese, VM | 1 |
| Terada, Y | 1 |
| Ueda, S | 1 |
| Hamada, K | 1 |
| Shimamura, Y | 1 |
| Ogata, K | 1 |
| Inoue, K | 1 |
| Taniguchi, Y | 1 |
| Kagawa, T | 1 |
| Horino, T | 1 |
| Takao, T | 1 |
| LIEBERMAN, ME | 1 |
| ANIBALDI, A | 2 |
| BOSCHERINI, B | 2 |
| PAIELLA, R | 1 |
| PATANE, E | 1 |
| PEDULLA, T | 1 |
| DELVAGLIO, B | 1 |
| SMITH, FG | 1 |
| LITMAN, N | 1 |
| LATTA, H | 1 |
| Aldigier, JC | 1 |
| Kanjanbuch, T | 1 |
| Ma, LJ | 1 |
| Brown, NJ | 1 |
| Fogo, AB | 1 |
| Piecha, G | 1 |
| Koleganova, N | 1 |
| Gross, ML | 1 |
| Geldyyev, A | 1 |
| Adamczak, M | 1 |
| Ritz, E | 1 |
| Maebashi, M | 2 |
| Yoshinaga, K | 2 |
| Lewy, JE | 1 |
| Black, JA | 1 |
| Challacombe, DN | 1 |
| Ockenden, BG | 1 |
| Lagrue, G | 1 |
| Fournier, A | 1 |
| Rawlins, MD | 1 |
| Silverberg, DS | 1 |
| Kjellstrand, CM | 1 |
| Loggie, JM | 1 |
| Miura, K | 1 |
| Goto, K | 1 |
| Katsushima, I | 1 |
| Praetorius, F | 1 |
| Neuhaus, GA | 1 |
| Horbach, L | 1 |
| Michaelis, J | 1 |
| Dürr, F | 1 |
| Kaufmann, W | 1 |
| Gentili, G | 1 |
| Liberti, R | 1 |
| Belci, C | 1 |
| Zegarra Puppi, J | 1 |
| Rivera Felices, J | 1 |
| Larrea Ramírez, P | 1 |
| Olivo, R | 1 |
4 reviews available for spironolactone and Glomerulonephritis
| Article | Year |
|---|---|
Aldosterone stimulates nuclear factor-kappa B activity and transcription of intercellular adhesion molecule-1 and connective tissue growth factor in rat mesangial cells via serum- and glucocorticoid-inducible protein kinase-1.
Topics: Aldosterone; Animals; Connective Tissue Growth Factor; Eplerenone; Glomerulonephritis; I-kappa B Pro | 2012 |
Diuretics in infancy.
Topics: Acute Disease; Benzothiadiazines; Diet, Sodium-Restricted; Diuretics; Diuretics, Osmotic; Edema; Eth | 1981 |
Variability in response to drugs.
Topics: Acute Disease; Acylation; Chlorthalidone; Chronic Disease; Depression; Diazoxide; Digoxin; Dose-Resp | 1974 |
Hypertension in children and adolescents. II. Drug therapy.
Topics: Age Factors; Antihypertensive Agents; Blood Pressure Determination; Child; Chlorothiazide; Chronic D | 1969 |
2 trials available for spironolactone and Glomerulonephritis
| Article | Year |
|---|---|
Intensive versus conventional therapy to slow the progression of idiopathic glomerular diseases.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Disease Progression; Dru | 2010 |
Clinical use of high doses of furosemide (Lasix) in the treatment of resistant nephrotic edema.
Topics: Adult; Clinical Trials as Topic; Diabetes Complications; Diuretics; Edema; Female; Furosemide; Glome | 1968 |
17 other studies available for spironolactone and Glomerulonephritis
| Article | Year |
|---|---|
Aldosterone is involved in the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes.
Topics: Aldosterone; Animals; beta Catenin; Disease Models, Animal; Down-Regulation; Eplerenone; Glomerulone | 2018 |
Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Dise | 2008 |
MEMBRANOUS GLOMERULONEPHRITIS: DISCUSSION AND CASE PRESENTATION.
Topics: Adolescent; Adrenocorticotropic Hormone; Biopsy; Cortisone; Diagnosis; Electrons; Glomerulonephritis | 1964 |
[EFFECTS OF HYDROCHLOROTHIAZIDE ASSOCIATED WITH ALDOSTERONE ANTAGONISTS IN THE THERAPY OF INFANTILE NEPHROTIC EDEMA. II. STUDY OF OSMOLAR CLEARANCES AND FREE WATER].
Topics: Child; Diuresis; Edema; Glomerulonephritis; Humans; Hydrochlorothiazide; Ketones; Kidney Function Te | 1963 |
[EFFECTS OF HYDROCHLOROTHIAZIDE ASSOCIATED WITH ALDOSTERONE IN THE THERAPY OF NEPHROTIC EDEMA. I. CLINICAL RESULTS AND STUDY OF WATER AND SALT METABOLISM IN 3 CASES].
Topics: Adrenocorticotropic Hormone; Aldosterone; Child; Edema; Glomerulonephritis; Humans; Hydrochlorothiaz | 1963 |
[EDEMAS AND SPIRONOLACTONES].
Topics: Edema; Female; Glomerulonephritis; Humans; Nephritis; Pregnancy; Pregnancy Complications; Premenstru | 1964 |
LUPUS GLOMERULONEPHRITIS. THE EFFECT OF LARGE DOSES OF CORTICOSTEROIDS ON RENAL FUNCTION AND RENAL LESIONS IN TWO CHILDREN.
Topics: Adolescent; Adrenal Cortex Hormones; Cortisone; Drug Therapy; Glomerulonephritis; Guanethidine; Hydr | 1965 |
Regression of existing glomerulosclerosis by inhibition of aldosterone.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Diuretics; Glomerulonephri | 2005 |
Regression of glomerulosclerosis in subtotally nephrectomized rats: effects of monotherapy with losartan, spironolactone, and their combination.
Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Collagen Type IV; Desmin; Dihydralazi | 2008 |
Changes in plasma renin activity after administration of spironolactone.
Topics: Adolescent; Adult; Aortic Coarctation; Blood Pressure; Cushing Syndrome; Female; Glomerulonephritis; | 1967 |
Nephrotic syndrome associated with bacteraemia after shunt operations for hydrocephalus.
Topics: Edema; Escherichia coli; Female; Fluorescent Antibody Technique; Glomerulonephritis; Humans; Hydroce | 1965 |
[Nephrology in 1972].
Topics: Bone Resorption; Calcium; Dextrans; Female; Fluorescent Antibody Technique; Gentamicins; Glomerulone | 1972 |
Suppressed plasma renin activity in in hypertensive patients--its evaluation for the diagnosis of primary aldosteronism.
Topics: Aldosterone; Cushing Syndrome; Diet, Sodium-Restricted; Glomerulonephritis; Humans; Hydrochlorothiaz | 1969 |
[Effect of diuretic measures in hydropic condition. 3. Results in nephrotic syndrome, comparison with other disease groups].
Topics: Adult; Body Weight; Diet, Sodium-Restricted; Diuresis; Diuretics; Edema; Female; Glomerulonephritis; | 1969 |
[Clinical study of the use of "Spirolang" 50].
Topics: Adult; Aged; Ascites; Chronic Disease; Digitalis Glycosides; Diuresis; Electrolytes; Ethacrynic Acid | 1971 |
[Transitory myopia in the course of therapy with diuretics].
Topics: Child; Female; Glomerulonephritis; Humans; Myopia; Spironolactone | 1968 |
[Nephrotic syndrome. Treatment and control with serial renal biopsy].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Biopsy; Blood Transfusion; Glomerulonephritis; Hum | 1966 |