spironolactone has been researched along with Glioblastoma in 3 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Osimertinib is a tyrosine kinase approved and effective in treating lung adenocarcinomas that have one of several common activating mutations in epidermal growth factor receptor." | 6.72 | OPALS: A New Osimertinib Adjunctive Treatment of Lung Adenocarcinoma or Glioblastoma Using Five Repurposed Drugs. ( Halatsch, ME; Kast, RE; Rosell, R, 2021) |
| "Osimertinib is a tyrosine kinase approved and effective in treating lung adenocarcinomas that have one of several common activating mutations in epidermal growth factor receptor." | 2.72 | OPALS: A New Osimertinib Adjunctive Treatment of Lung Adenocarcinoma or Glioblastoma Using Five Repurposed Drugs. ( Halatsch, ME; Kast, RE; Rosell, R, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aldaz, P | 1 |
| Fernández-Celis, A | 1 |
| López-Andrés, N | 1 |
| Arozarena, I | 1 |
| Kast, RE | 2 |
| Burns, TC | 1 |
| Halatsch, ME | 2 |
| Rosell, R | 1 |
1 review available for spironolactone and Glioblastoma
| Article | Year |
|---|---|
OPALS: A New Osimertinib Adjunctive Treatment of Lung Adenocarcinoma or Glioblastoma Using Five Repurposed Drugs.
Topics: Acrylamides; Adenocarcinoma of Lung; Aniline Compounds; Animals; Azithromycin; Carcinoma, Non-Small- | 2021 |
2 other studies available for spironolactone and Glioblastoma
| Article | Year |
|---|---|
Novel Insights into the Role of the Mineralocorticoid Receptor in Human Glioblastoma.
Topics: Aldosterone; Cell Line, Tumor; Glioblastoma; Humans; Neoplastic Stem Cells; Receptors, Mineralocorti | 2021 |
Short review of SEC, a potential dexamethasone-sparing regimen for glioblastoma: Spironolactone, ecallantide, clotrimazole.
Topics: Clotrimazole; Dexamethasone; Glioblastoma; Humans; Peptides; Pilot Projects; Spironolactone | 2021 |