spironolactone has been researched along with Glaucoma in 6 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to eliminate a previously reported stimulation of aqueous humor production by aldosterone, 22 glaucoma patients were treated for two weeks with 200 mg Spironolactone daily." | 7.66 | [Effect of spironolactone on intraocular pressure in glaucoma patients]. ( Witzmann, R, 1980) |
| "Aldosterone was administered via an osmotic minipump that was implanted subcutaneously into the mid-scapular region." | 5.39 | Aldosterone: a mediator of retinal ganglion cell death and the potential role in the pathogenesis in normal-tension glaucoma. ( Fujita, T; Hirooka, K; Itano, T; Nakamura, T; Nishiyama, A; Nitta, E; Shiraga, F; Tenkumo, K, 2013) |
| "Aldosterone was administered via an osmotic minipump that was implanted subcutaneously into the mid-scapular region." | 1.39 | Aldosterone: a mediator of retinal ganglion cell death and the potential role in the pathogenesis in normal-tension glaucoma. ( Fujita, T; Hirooka, K; Itano, T; Nakamura, T; Nishiyama, A; Nitta, E; Shiraga, F; Tenkumo, K, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nitta, E | 1 |
| Hirooka, K | 1 |
| Tenkumo, K | 1 |
| Fujita, T | 1 |
| Nishiyama, A | 1 |
| Nakamura, T | 1 |
| Itano, T | 1 |
| Shiraga, F | 1 |
| Sevcik, J | 1 |
| Pullmann, R | 1 |
| Pitiová, G | 1 |
| Witzmann, R | 1 |
| Marone, C | 1 |
| Beretta-Piccoli, C | 1 |
| Weidmann, P | 1 |
| Selchau, M | 1 |
| Schmidt, P | 1 |
1 review available for spironolactone and Glaucoma
| Article | Year |
|---|---|
[Diuretics. 47].
Topics: Antihypertensive Agents; Bendroflumethiazide; Chlorothiazide; Chlorthalidone; Clopamide; Dichlorphen | 1970 |
5 other studies available for spironolactone and Glaucoma
| Article | Year |
|---|---|
Aldosterone: a mediator of retinal ganglion cell death and the potential role in the pathogenesis in normal-tension glaucoma.
Topics: Aldosterone; Animals; Apoptosis; Cell Survival; Glaucoma; Intraocular Pressure; Male; Mineralocortic | 2013 |
[Participation of aldosterone in pathogenesis of primary glaucoma (author's transl)].
Topics: Aldosterone; Glaucoma; Humans; Intraocular Pressure; Spironolactone | 1981 |
[Effect of spironolactone on intraocular pressure in glaucoma patients].
Topics: Glaucoma; Humans; Intraocular Pressure; Spironolactone | 1980 |
[Basis and clinical aspects of diuretic drug therapy].
Topics: Acetazolamide; Benzothiadiazines; Diuretics; Edema; Edema, Cardiac; Furosemide; Glaucoma; Humans; Hy | 1979 |
[Diuresis and diuretics].
Topics: Acetazolamide; Acute Disease; Agranulocytosis; Anuria; Biological Transport; Blood Platelet Disorder | 1971 |