spironolactone has been researched along with Genetic Predisposition in 5 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aldosterone is a risk factor for stroke, and the literature suggests it may play a role in increasing the expression of the receptor for EGF (EGFR)." | 5.31 | Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats. ( Dorrance, AM; Grekin, R; Osborn, HL; Webb, RC, 2001) |
| "Metformin has proven to be effective in the management of the metabolic disturbances, anovulation and hirsutism and is now a widely accepted therapy." | 2.43 | [Polycystic ovary syndrome. New pathophysiological discoveries--therapeutic consequences]. ( Madsbad, S; Nilas, L; Nørgaard, K; Svendsen, PF, 2005) |
| "Treatment with spironolactone or potassium supplements alone significantly increased serum potassium concentration by 0." | 1.46 | Mutation profile and treatment of Gitelman syndrome in Chinese patients. ( Cui, Y; Li, C; Shi, C; Tong, A; Wang, F, 2017) |
| "Inherited classic Bartter syndrome (cBS) is an autosomal recessive renal tubular disorder resulting from inactivating mutations in the asolateral chloride channel (C1C-Kb) and usually presents in early infancy or childhood with mild to moderate hypokalemia." | 1.40 | Hypokalemic paralysis in a middle-aged female with classic Bartter syndrome. ( Chan, JS; Chiang, WF; Lin, SH, 2014) |
| "Aldosterone is a risk factor for stroke, and the literature suggests it may play a role in increasing the expression of the receptor for EGF (EGFR)." | 1.31 | Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats. ( Dorrance, AM; Grekin, R; Osborn, HL; Webb, RC, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, F | 1 |
| Shi, C | 1 |
| Cui, Y | 1 |
| Li, C | 1 |
| Tong, A | 1 |
| Chiang, WF | 1 |
| Lin, SH | 2 |
| Chan, JS | 1 |
| Svendsen, PF | 1 |
| Nilas, L | 1 |
| Nørgaard, K | 1 |
| Madsbad, S | 1 |
| Funder, JW | 1 |
| Dorrance, AM | 1 |
| Osborn, HL | 1 |
| Grekin, R | 1 |
| Webb, RC | 1 |
1 review available for spironolactone and Genetic Predisposition
| Article | Year |
|---|---|
[Polycystic ovary syndrome. New pathophysiological discoveries--therapeutic consequences].
Topics: Contraceptives, Oral; Diabetes Mellitus, Type 2; Female; Genetic Predisposition to Disease; Humans; | 2005 |
4 other studies available for spironolactone and Genetic Predisposition
| Article | Year |
|---|---|
Mutation profile and treatment of Gitelman syndrome in Chinese patients.
Topics: Adolescent; Adult; Asian People; China; Dietary Supplements; Diuretics; DNA Mutational Analysis; Fem | 2017 |
Hypokalemic paralysis in a middle-aged female with classic Bartter syndrome.
Topics: Bartter Syndrome; Chloride Channels; Dietary Supplements; Diuretics; Female; Genetic Predisposition | 2014 |
Translational research goes both ways: lessons from clinical studies.
Topics: Aldosterone; Amino Acid Sequence; Antihypertensive Agents; Biomedical Research; Clinical Trials as T | 2008 |
Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats.
Topics: Aldosterone; Animals; Aorta; Basal Ganglia; Blood Pressure; Body Weight; Cerebral Cortex; Cerebral I | 2001 |