spironolactone has been researched along with Gastrointestinal Hemorrhage in 20 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of spironolactone on esophageal variceal pressure (VP) in patients without ascites was investigated." | 9.08 | The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites. ( Fevery, J; Lijnen, P; Nevens, F; VanBilloen, H, 1996) |
| " He developed nonA-nonB-induced liver cirrhosis and had been treated with spironolactone for the last 6 years." | 7.68 | Reversal of andro-genetic alopecia in a male. A spironolactone effect? ( Bou-Abboud, CF; Nemec, F; Toffel, F, 1990) |
| "The effect of spironolactone on esophageal variceal pressure (VP) in patients without ascites was investigated." | 5.08 | The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites. ( Fevery, J; Lijnen, P; Nevens, F; VanBilloen, H, 1996) |
| " He developed nonA-nonB-induced liver cirrhosis and had been treated with spironolactone for the last 6 years." | 3.68 | Reversal of andro-genetic alopecia in a male. A spironolactone effect? ( Bou-Abboud, CF; Nemec, F; Toffel, F, 1990) |
| "Portal hypertension is one of the main consequences of cirrhosis." | 2.43 | Current management of the complications of portal hypertension: variceal bleeding and ascites. ( Calès, P; Dib, N; Oberti, F, 2006) |
| "Terlipressin has longer effects and is more effective and safer than vasopressin alone or in combination with nitroglycerin." | 2.41 | The sixth Carlos E. Rubio Memorial Lecture. Prevention and treatment of variceal hemorrhage. ( Bosch, J, 2000) |
| "Spironolactone is a potassium-sparing diuretic marketed since the 1960s that is known to cause the same adverse effects as other diuretics as well as some effects of its own, such as hyperkalaemia, gynaecomastia and menstrual disturbances." | 1.37 | Upper gastrointestinal bleeding and spironolactone. ( , 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (35.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, M | 1 |
| Qi, X | 1 |
| Yang, M | 1 |
| Han, G | 1 |
| Fan, D | 1 |
| Gulmez, SE | 1 |
| Lassen, AT | 1 |
| Aalykke, C | 1 |
| Dall, M | 1 |
| Andries, A | 1 |
| Andersen, BS | 1 |
| Hansen, JM | 1 |
| Andersen, M | 1 |
| Hallas, J | 1 |
| CHAPIS, NJ | 1 |
| Dib, N | 1 |
| Oberti, F | 1 |
| Calès, P | 1 |
| Jones, GP | 1 |
| Russo, A | 1 |
| Autelitano, M | 1 |
| Bisanti, L | 1 |
| De, BK | 1 |
| Dutta, D | 1 |
| Som, R | 1 |
| Biswas, PK | 1 |
| Pal, SK | 1 |
| Biswas, A | 1 |
| Trewby, PN | 1 |
| Nevens, F | 2 |
| Lijnen, P | 1 |
| VanBilloen, H | 1 |
| Fevery, J | 1 |
| Bosch, J | 1 |
| Bou-Abboud, CF | 1 |
| Nemec, F | 1 |
| Toffel, F | 1 |
| Marcos Sánchez, F | 1 |
| Aguirre de Cárcer, A | 1 |
| Durán Pérez-Navarro, A | 1 |
| Inberg, MV | 1 |
| Harjola, PT | 1 |
| Scheinin, TM | 1 |
| Ilinich, VK | 1 |
| Plastun, FF | 1 |
| Wohlenberg, H | 1 |
6 reviews available for spironolactone and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Combined therapies versus monotherapies for the first variceal bleeding in patients with high-risk varices: a meta-analysis of randomized controlled trials.
Topics: Combined Modality Therapy; Databases, Bibliographic; Drug Therapy, Combination; Endpoint Determinati | 2014 |
Bleeding from ruptured oesophageal varices: propranolol for primary prevention.
Topics: Adrenergic beta-Antagonists; Combined Modality Therapy; Diuretics; Endoscopy; Esophageal and Gastric | 2012 |
Current management of the complications of portal hypertension: variceal bleeding and ascites.
Topics: Algorithms; Anti-Bacterial Agents; Ascites; Collateral Circulation; Diuretics; Endoscopy, Gastrointe | 2006 |
Drug-induced peptic ulcer and upper gastrointestinal bleeding.
Topics: Adrenal Cortex Hormones; Alcoholism; Animals; Aspirin; Diuretics; Emepronium; Female; Gastrointestin | 1980 |
The sixth Carlos E. Rubio Memorial Lecture. Prevention and treatment of variceal hemorrhage.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Double-Blind Method; Drug Therapy, Combination | 2000 |
[Treatment of acute hepatic insufficiency (a survey of the literature)].
Topics: Acute Disease; Adenosine Triphosphate; Arginine; Chemical and Drug Induced Liver Injury; Exchange Tr | 1972 |
3 trials available for spironolactone and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Hemodynamic effects of propranolol with spironolactone in patients with variceal bleeds: a randomized controlled trial.
Topics: Adrenergic beta-Antagonists; Adult; Diuretics; Drug Therapy, Combination; Esophageal and Gastric Var | 2008 |
The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Ascites; Atrial Natriuretic Factor; | 1996 |
Non-invasive variceal pressure measurements: validation and clinical implications.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure Determination; Double-Blind Method; Esophageal | 1996 |
11 other studies available for spironolactone and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Spironolactone use and the risk of upper gastrointestinal bleeding: a population-based case-control study.
Topics: Aged; Case-Control Studies; Denmark; Diuretics; Dose-Response Relationship, Drug; Duodenal Ulcer; Ep | 2008 |
Slow adoption of helpful heart failure drug. Many people who could benefit from spironolactone aren't getting it.
Topics: Drug Utilization; Female; Gastrointestinal Hemorrhage; Health Education; Health Knowledge, Attitudes | 2010 |
Upper gastrointestinal bleeding and spironolactone.
Topics: Diuretics; Dose-Response Relationship, Drug; Gastrointestinal Hemorrhage; Humans; Mineralocorticoid | 2011 |
PORTACAVAL SHUNT PERFORMED DURING PREGNANCY.
Topics: Chlorothiazide; Diet, Sodium-Restricted; Esophageal and Gastric Varices; Female; Gastrointestinal He | 1964 |
Spironolactone and risk of upper gastrointestinal events: causality remains unconvincing.
Topics: Gastrointestinal Hemorrhage; Humans; Mineralocorticoid Receptor Antagonists; Risk Factors; Spironola | 2006 |
Spironolactone and gastrointestinal bleeding: a population based study.
Topics: Aged; Aged, 80 and over; Bias; Cohort Studies; Diuretics; Dose-Response Relationship, Drug; Female; | 2008 |
Reversal of andro-genetic alopecia in a male. A spironolactone effect?
Topics: Aged; Alopecia; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hair; Humans; Liver Cir | 1990 |
[Upper digestive hemorrhage caused by recurrent gastritis. Adverse effects of spironolactone].
Topics: Aged; Gastritis; Gastrointestinal Hemorrhage; Humans; Male; Recurrence; Spironolactone | 1985 |
Role of the mesentericocaval shunt in the management of portal hypertension.
Topics: Adolescent; Adult; Diuretics; Duodenal Ulcer; Edema; Female; Follow-Up Studies; Gastrointestinal Hem | 1974 |
Medical grand rounds from the University of Alabama Medical Center.
Topics: Alcoholism; Antacids; Ascites; Biopsy; Blood Transfusion; Collateral Circulation; Esophageal and Gas | 1969 |
[Myelofibrosis and esophageal varices].
Topics: Aged; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Hypertension, Por | 1969 |