spironolactone has been researched along with Familial Hypokalemia-Hypomagnesemia in 18 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indomethacin was the most effective but can cause gastrointestinal intolerance and decreased eGFR." | 6.80 | Indomethacin, amiloride, or eplerenone for treating hypokalemia in Gitelman syndrome. ( Allard, J; Azizi, M; Baron, S; Bergerot, D; Blanchard, A; Bridoux, F; Caumont-Prim, A; Desport, E; Dubourg, L; Essig, M; Monge, M; Tack, I; Vallet, M; Vargas-Poussou, R, 2015) |
| "These findings were compatible with Gitelman's syndrome (GS)." | 5.38 | Eplerenone improved hypokalemia in a patient with Gitelman's syndrome. ( Ito, Y; Maeda, H; Miyata, M; Nakayama, M; Ogawa, K; Oiso, Y; Tsutaya, S; Yoshida, M, 2012) |
| " Hypokalemia and hypomagnesemia in GS were difficult to correct; however, spironolactone might be helpful for hypokalemia to some degree." | 3.83 | Genotype/Phenotype Analysis in 67 Chinese Patients with Gitelman's Syndrome. ( Lang, Y; Liu, T; Lu, J; Shao, L; Wang, C; Zhao, X, 2016) |
| "Indomethacin was the most effective but can cause gastrointestinal intolerance and decreased eGFR." | 2.80 | Indomethacin, amiloride, or eplerenone for treating hypokalemia in Gitelman syndrome. ( Allard, J; Azizi, M; Baron, S; Bergerot, D; Blanchard, A; Bridoux, F; Caumont-Prim, A; Desport, E; Dubourg, L; Essig, M; Monge, M; Tack, I; Vallet, M; Vargas-Poussou, R, 2015) |
| "Acquired Gitelman syndrome is a very rare disorder reported in association with autoimmune disorders, mostly Sjögren syndrome." | 2.72 | Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjögren syndrome: a case report and literature review. ( Gunapala, A; Perera, S; Ranaweerage, R, 2021) |
| "These features were consistent with the Gitelman syndrome." | 1.56 | Systemic lupus erythematosus complicated by a Gitelman-like syndrome in an 8-year-old girl. ( Barathidasan, GS; Dhandapany, G; Ganesh, RN; Karunakar, P; Krishnamurthy, S; Rajendran, R; Ramamoorthy, JG; Ramya, K, 2020) |
| " There are only a few reports on GS combined with growth hormone deficiency (GHD)." | 1.51 | Gitelman syndrome combined with growth hormone deficiency: Three cases report. ( Dai, YL; Dong, GP; Fei, Y; Fu, JF; Huang, K; Ullah, R; Wu, W; Zhang, JW; Zhang, L, 2019) |
| "Treatment with spironolactone or potassium supplements alone significantly increased serum potassium concentration by 0." | 1.46 | Mutation profile and treatment of Gitelman syndrome in Chinese patients. ( Cui, Y; Li, C; Shi, C; Tong, A; Wang, F, 2017) |
| "We report a case of Gitelman syndrome presenting with fatigue, paresthesias, weakness of limbs and neck muscles since 2." | 1.38 | Gitelman syndrome: novel mutation and long-term follow-up. ( Bagga, A; Basu, B; Gulati, A; Hari, P; Lněnička, P; Sinha, A, 2012) |
| "These findings were compatible with Gitelman's syndrome (GS)." | 1.38 | Eplerenone improved hypokalemia in a patient with Gitelman's syndrome. ( Ito, Y; Maeda, H; Miyata, M; Nakayama, M; Ogawa, K; Oiso, Y; Tsutaya, S; Yoshida, M, 2012) |
| "Seventeen patients with Gitelman syndrome (male/female: 11/6) were analyzed for their clinical symptoms, laboratory test results, imaging findings, treatments and outcomes." | 1.38 | [Clinical analysis of 17 cases of Gitelman syndrome]. ( Mu, YM; Qu, L; Zhang, TT, 2012) |
| "A diagnosis of Gitelman syndrome was made." | 1.37 | Quadriparesis in an adult--Gitelman syndrome. ( Ahmed, S; Farooq, F; Qayyum, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 14 (77.78) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, K | 1 |
| Dai, YL | 1 |
| Zhang, JW | 1 |
| Zhang, L | 1 |
| Wu, W | 1 |
| Dong, GP | 1 |
| Ullah, R | 1 |
| Fei, Y | 1 |
| Fu, JF | 1 |
| Barathidasan, GS | 1 |
| Krishnamurthy, S | 1 |
| Karunakar, P | 1 |
| Rajendran, R | 1 |
| Ramya, K | 1 |
| Dhandapany, G | 1 |
| Ramamoorthy, JG | 1 |
| Ganesh, RN | 1 |
| Ranaweerage, R | 1 |
| Perera, S | 1 |
| Gunapala, A | 1 |
| Blanchard, A | 1 |
| Vargas-Poussou, R | 1 |
| Vallet, M | 1 |
| Caumont-Prim, A | 1 |
| Allard, J | 1 |
| Desport, E | 1 |
| Dubourg, L | 1 |
| Monge, M | 1 |
| Bergerot, D | 1 |
| Baron, S | 1 |
| Essig, M | 1 |
| Bridoux, F | 1 |
| Tack, I | 1 |
| Azizi, M | 1 |
| Wang, F | 1 |
| Shi, C | 1 |
| Cui, Y | 1 |
| Li, C | 1 |
| Tong, A | 1 |
| Liu, T | 1 |
| Wang, C | 1 |
| Lu, J | 1 |
| Zhao, X | 1 |
| Lang, Y | 1 |
| Shao, L | 1 |
| de Arriba, G | 1 |
| Sánchez-Heras, M | 1 |
| Basterrechea, MA | 1 |
| Ceri, M | 1 |
| Unverdi, S | 1 |
| Altay, M | 1 |
| Unverdi, H | 1 |
| Kurultak, I | 1 |
| Yılmaz, R | 1 |
| Ensari, A | 1 |
| Duranay, M | 1 |
| Sundar, U | 1 |
| Lakkas, Y | 1 |
| Asole, D | 1 |
| Vaidya, M | 1 |
| Bandyopadhyay, SK | 1 |
| Datt, S | 1 |
| Pal, SK | 1 |
| Saha, AK | 1 |
| Morton, A | 2 |
| Panitz, B | 1 |
| Bush, A | 1 |
| Ahmed, S | 1 |
| Qayyum, M | 1 |
| Farooq, F | 1 |
| Sinha, A | 1 |
| Lněnička, P | 2 |
| Basu, B | 1 |
| Gulati, A | 1 |
| Hari, P | 1 |
| Bagga, A | 1 |
| Ito, Y | 1 |
| Yoshida, M | 1 |
| Nakayama, M | 1 |
| Tsutaya, S | 1 |
| Ogawa, K | 1 |
| Maeda, H | 1 |
| Miyata, M | 1 |
| Oiso, Y | 1 |
| Qu, L | 1 |
| Zhang, TT | 1 |
| Mu, YM | 1 |
| Park, PG | 1 |
| Karet Frankl, FE | 1 |
| Skalova, S | 1 |
| Neuman, D | 1 |
| Stekrova, J | 1 |
1 review available for spironolactone and Familial Hypokalemia-Hypomagnesemia
| Article | Year |
|---|---|
Hypokalaemic paralysis and metabolic alkalosis in a patient with Sjögren syndrome: a case report and literature review.
Topics: Diagnosis, Differential; Dietary Supplements; Gitelman Syndrome; Humans; Hypokalemia; Paralysis; Pot | 2021 |
1 trial available for spironolactone and Familial Hypokalemia-Hypomagnesemia
| Article | Year |
|---|---|
Indomethacin, amiloride, or eplerenone for treating hypokalemia in Gitelman syndrome.
Topics: Adolescent; Adult; Amiloride; Blood Pressure; Body Weight; Cross-Over Studies; Dose-Response Relatio | 2015 |
16 other studies available for spironolactone and Familial Hypokalemia-Hypomagnesemia
| Article | Year |
|---|---|
Gitelman syndrome combined with growth hormone deficiency: Three cases report.
Topics: Child; Child, Preschool; Female; Gitelman Syndrome; Growth Hormone; Human Growth Hormone; Humans; Ma | 2019 |
Systemic lupus erythematosus complicated by a Gitelman-like syndrome in an 8-year-old girl.
Topics: Alkalosis; Child; Cyclophosphamide; Drug Therapy, Combination; Female; Gitelman Syndrome; Humans; Hy | 2020 |
Mutation profile and treatment of Gitelman syndrome in Chinese patients.
Topics: Adolescent; Adult; Asian People; China; Dietary Supplements; Diuretics; DNA Mutational Analysis; Fem | 2017 |
Genotype/Phenotype Analysis in 67 Chinese Patients with Gitelman's Syndrome.
Topics: Adult; Asian People; Calcium; Diabetes Mellitus, Type 2; Diuretics; Female; Genotype; Gitelman Syndr | 2016 |
Gitelman syndrome during pregnancy: a therapeutic challenge.
Topics: Adult; Diuretics; Female; Gitelman Syndrome; Humans; Infant, Newborn; Magnesium; Male; Potassium; Pr | 2009 |
Focal segmental glomerulosclerosis in association with Gitelman syndrome.
Topics: Adult; Dietary Supplements; Diuretics; Gitelman Syndrome; Glomerulosclerosis, Focal Segmental; Human | 2011 |
Gitelman's syndrome presenting as recurrent paralytic ileus due to chronic renal tubular K+ wasting.
Topics: Alkalosis; Bartter Syndrome; Calcium; Chronic Disease; Diagnosis, Differential; Diuretics; Gitelman | 2010 |
Gitelman's syndrome: a differential diagnosis of normocalcemic tetany.
Topics: Adult; Calcium; Diagnosis, Differential; Diuretics; Female; Gitelman Syndrome; Humans; Magnesium; Ma | 2010 |
Eplerenone for gitelman syndrome in pregnancy.
Topics: Eplerenone; Female; Gitelman Syndrome; Humans; Live Birth; Mineralocorticoid Receptor Antagonists; M | 2011 |
Quadriparesis in an adult--Gitelman syndrome.
Topics: Alkalosis; Calcium; Gitelman Syndrome; Humans; Hypokalemia; Magnesium; Magnesium Deficiency; Male; M | 2011 |
Gitelman syndrome: novel mutation and long-term follow-up.
Topics: Child; Diuretics; Female; Follow-Up Studies; Gitelman Syndrome; Humans; Hypokalemia; Magnesium; Muta | 2012 |
Eplerenone improved hypokalemia in a patient with Gitelman's syndrome.
Topics: Base Sequence; DNA Mutational Analysis; Eplerenone; Female; Gitelman Syndrome; Humans; Hypokalemia; | 2012 |
[Clinical analysis of 17 cases of Gitelman syndrome].
Topics: Adolescent; Adult; Child; Female; Gitelman Syndrome; Humans; Indomethacin; Male; Middle Aged; Potass | 2012 |
Gitelman syndrome.
Topics: Disease Management; General Practitioners; Gitelman Syndrome; Humans; Hypokalemia; Interprofessional | 2012 |
Gitelman syndrome as a cause of psychomotor retardation in a toddler.
Topics: Dietary Supplements; Diuretics; Failure to Thrive; Gitelman Syndrome; Humans; Infant; Male; Potassiu | 2013 |
Eplerenone in the treatment of Gitelman's syndrome.
Topics: Adult; Eplerenone; Female; Gitelman Syndrome; Humans; Spironolactone; Treatment Outcome | 2008 |