spironolactone has been researched along with Experimental Radiation Injuries in 2 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spironolactone treatment, however, significantly prevented the development of histopathologic and functional changes (BUN 31." | 1.33 | Mitigation of radiation nephropathy after internal alpha-particle irradiation of kidneys. ( Hyjek, E; Jaggi, JS; McDevitt, MR; Scheinberg, DA; Seshan, SV; Sgouros, G, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jaggi, JS | 1 |
| Seshan, SV | 1 |
| McDevitt, MR | 1 |
| Sgouros, G | 1 |
| Hyjek, E | 1 |
| Scheinberg, DA | 1 |
| Zsebök, ZB | 1 |
| Baumgartner, E | 1 |
| Jánossy, G | 1 |
2 other studies available for spironolactone and Experimental Radiation Injuries
| Article | Year |
|---|---|
Mitigation of radiation nephropathy after internal alpha-particle irradiation of kidneys.
Topics: Actinium; Alpha Particles; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood | 2006 |
[Effect of corticoids on the survival of animals irradiated with supralethal doses].
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Cortisone; Glucocorticoids; Male; Mineralocorti | 1968 |