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spironolactone and Esophageal and Gastric Varices

spironolactone has been researched along with Esophageal and Gastric Varices in 18 studies

Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Esophageal and Gastric Varices: Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).

Research Excerpts

ExcerptRelevanceReference
"The effect of spironolactone on esophageal variceal pressure (VP) in patients without ascites was investigated."9.08The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites. ( Fevery, J; Lijnen, P; Nevens, F; VanBilloen, H, 1996)
" He developed nonA-nonB-induced liver cirrhosis and had been treated with spironolactone for the last 6 years."7.68Reversal of andro-genetic alopecia in a male. A spironolactone effect? ( Bou-Abboud, CF; Nemec, F; Toffel, F, 1990)
"The effect of spironolactone on esophageal variceal pressure (VP) in patients without ascites was investigated."5.08The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites. ( Fevery, J; Lijnen, P; Nevens, F; VanBilloen, H, 1996)
" He developed nonA-nonB-induced liver cirrhosis and had been treated with spironolactone for the last 6 years."3.68Reversal of andro-genetic alopecia in a male. A spironolactone effect? ( Bou-Abboud, CF; Nemec, F; Toffel, F, 1990)
"Pregnancy is rare in women with decompensated chronic liver disease."2.47Successful pregnancy outcome in decompensated chronic liver disease with portal vein thrombosis: case report and review of literature. ( Hussain, R; Kamani, L; Kumar, M; Siddique, S, 2011)
"Portal hypertension is one of the main consequences of cirrhosis."2.43Current management of the complications of portal hypertension: variceal bleeding and ascites. ( Calès, P; Dib, N; Oberti, F, 2006)
"Terlipressin has longer effects and is more effective and safer than vasopressin alone or in combination with nitroglycerin."2.41The sixth Carlos E. Rubio Memorial Lecture. Prevention and treatment of variceal hemorrhage. ( Bosch, J, 2000)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19907 (38.89)18.7374
1990's4 (22.22)18.2507
2000's4 (22.22)29.6817
2010's3 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bai, M1
Qi, X1
Yang, M1
Han, G1
Fan, D1
Kumar, M1
Kamani, L1
Hussain, R1
Siddique, S1
Abecasis, R1
Kravetz, D1
Fassio, E1
Ameigeiras, B1
Garcia, D1
Isla, R1
Landeira, G1
Dominguez, N1
Romero, G1
Argonz, J1
Terg, R1
CHAPIS, NJ1
Dib, N1
Oberti, F1
Calès, P1
De, BK1
Dutta, D1
Som, R1
Biswas, PK1
Pal, SK1
Biswas, A1
Nevens, F2
Lijnen, P1
VanBilloen, H1
Fevery, J1
Sugano, S1
Suzuki, T1
Nishio, M1
Makino, H1
Okajima, T1
Bosch, J1
Bou-Abboud, CF1
Nemec, F1
Toffel, F1
Kuntz, E1
Kommerell, B1
Felder, KD1
Wernze, H1
Brunswig, D1
Wohlenberg, H1
Weinreich, J1

Reviews

6 reviews available for spironolactone and Esophageal and Gastric Varices

ArticleYear
Combined therapies versus monotherapies for the first variceal bleeding in patients with high-risk varices: a meta-analysis of randomized controlled trials.
    Journal of gastroenterology and hepatology, 2014, Volume: 29, Issue:3

    Topics: Combined Modality Therapy; Databases, Bibliographic; Drug Therapy, Combination; Endpoint Determinati

2014
Successful pregnancy outcome in decompensated chronic liver disease with portal vein thrombosis: case report and review of literature.
    European journal of gastroenterology & hepatology, 2011, Volume: 23, Issue:7

    Topics: Adult; Antiviral Agents; Ascites; Blood Transfusion; Esophageal and Gastric Varices; Female; Hepatit

2011
Bleeding from ruptured oesophageal varices: propranolol for primary prevention.
    Prescrire international, 2012, Volume: 21, Issue:125

    Topics: Adrenergic beta-Antagonists; Combined Modality Therapy; Diuretics; Endoscopy; Esophageal and Gastric

2012
Current management of the complications of portal hypertension: variceal bleeding and ascites.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2006, May-09, Volume: 174, Issue:10

    Topics: Algorithms; Anti-Bacterial Agents; Ascites; Collateral Circulation; Diuretics; Endoscopy, Gastrointe

2006
The sixth Carlos E. Rubio Memorial Lecture. Prevention and treatment of variceal hemorrhage.
    Puerto Rico health sciences journal, 2000, Volume: 19, Issue:1

    Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Double-Blind Method; Drug Therapy, Combination

2000
[Hepatogenous (secondary) aldosteronism (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1974, May-17, Volume: 116, Issue:20

    Topics: Aldosterone; Angiotensin II; Chronic Disease; Esophageal and Gastric Varices; Hepatitis; Hepatitis A

1974

Trials

5 trials available for spironolactone and Esophageal and Gastric Varices

ArticleYear
Nadolol plus spironolactone in the prophylaxis of first variceal bleed in nonascitic cirrhotic patients: A preliminary study.
    Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:2

    Topics: Adrenergic beta-Antagonists; Aged; Double-Blind Method; Drug Therapy, Combination; Esophageal and Ga

2003
Hemodynamic effects of propranolol with spironolactone in patients with variceal bleeds: a randomized controlled trial.
    World journal of gastroenterology, 2008, Mar-28, Volume: 14, Issue:12

    Topics: Adrenergic beta-Antagonists; Adult; Diuretics; Drug Therapy, Combination; Esophageal and Gastric Var

2008
The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites.
    Hepatology (Baltimore, Md.), 1996, Volume: 23, Issue:5

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Ascites; Atrial Natriuretic Factor;

1996
Non-invasive variceal pressure measurements: validation and clinical implications.
    Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1996, Volume: 58, Issue:4

    Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure Determination; Double-Blind Method; Esophageal

1996
Chronic splanchnic hemodynamic effects of low-dose transdermal nitroglycerin versus low-dose transdermal nitroglycerin plus spironolactone in patients with cirrhosis.
    Digestive diseases and sciences, 1997, Volume: 42, Issue:3

    Topics: Administration, Cutaneous; Aged; Dose-Response Relationship, Drug; Drug Therapy, Combination; Esopha

1997

Other Studies

7 other studies available for spironolactone and Esophageal and Gastric Varices

ArticleYear
PORTACAVAL SHUNT PERFORMED DURING PREGNANCY.
    American journal of obstetrics and gynecology, 1964, Sep-15, Volume: 90

    Topics: Chlorothiazide; Diet, Sodium-Restricted; Esophageal and Gastric Varices; Female; Gastrointestinal He

1964
Reversal of andro-genetic alopecia in a male. A spironolactone effect?
    Acta dermato-venereologica, 1990, Volume: 70, Issue:4

    Topics: Aged; Alopecia; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hair; Humans; Liver Cir

1990
[Therapy of liver cirrhosis].
    Minerva medica, 1972, Dec-26, Volume: 63, Issue:93

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Diet, Sodium-Restricted; Esophageal and Gastric V

1972
[Pregnancy in liver cirrhosis. Internal medicine and gynecological aspects].
    Medizinische Klinik, 1973, Apr-20, Volume: 68, Issue:16

    Topics: Adult; Ascites; Colon; Diet, Sodium-Restricted; Diuretics; Esophageal and Gastric Varices; Esophagea

1973
Medical grand rounds from the University of Alabama Medical Center.
    Southern medical journal, 1969, Volume: 62, Issue:3

    Topics: Alcoholism; Antacids; Ascites; Biopsy; Blood Transfusion; Collateral Circulation; Esophageal and Gas

1969
[Myelofibrosis and esophageal varices].
    Deutsche medizinische Wochenschrift (1946), 1969, Oct-17, Volume: 94, Issue:42

    Topics: Aged; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Hypertension, Por

1969
[Portal hypertension in chronic liver diseases and its therapy].
    Medizinische Monatsschrift, 1969, Volume: 23, Issue:2

    Topics: Ascites; Chronic Disease; Esophageal and Gastric Varices; Humans; Hypertension, Portal; Liver Cirrho

1969
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