spironolactone and Esophageal and Gastric Varices
spironolactone has been researched along with Esophageal and Gastric Varices in 18 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Esophageal and Gastric Varices: Dilated blood vessels in the ESOPHAGUS or GASTRIC FUNDUS that shunt blood from the portal circulation (PORTAL SYSTEM) to the systemic venous circulation. Often they are observed in individuals with portal hypertension (HYPERTENSION, PORTAL).
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"The effect of spironolactone on esophageal variceal pressure (VP) in patients without ascites was investigated." | 9.08 | The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites. ( Fevery, J; Lijnen, P; Nevens, F; VanBilloen, H, 1996) |
" He developed nonA-nonB-induced liver cirrhosis and had been treated with spironolactone for the last 6 years." | 7.68 | Reversal of andro-genetic alopecia in a male. A spironolactone effect? ( Bou-Abboud, CF; Nemec, F; Toffel, F, 1990) |
"The effect of spironolactone on esophageal variceal pressure (VP) in patients without ascites was investigated." | 5.08 | The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites. ( Fevery, J; Lijnen, P; Nevens, F; VanBilloen, H, 1996) |
" He developed nonA-nonB-induced liver cirrhosis and had been treated with spironolactone for the last 6 years." | 3.68 | Reversal of andro-genetic alopecia in a male. A spironolactone effect? ( Bou-Abboud, CF; Nemec, F; Toffel, F, 1990) |
"Pregnancy is rare in women with decompensated chronic liver disease." | 2.47 | Successful pregnancy outcome in decompensated chronic liver disease with portal vein thrombosis: case report and review of literature. ( Hussain, R; Kamani, L; Kumar, M; Siddique, S, 2011) |
"Portal hypertension is one of the main consequences of cirrhosis." | 2.43 | Current management of the complications of portal hypertension: variceal bleeding and ascites. ( Calès, P; Dib, N; Oberti, F, 2006) |
"Terlipressin has longer effects and is more effective and safer than vasopressin alone or in combination with nitroglycerin." | 2.41 | The sixth Carlos E. Rubio Memorial Lecture. Prevention and treatment of variceal hemorrhage. ( Bosch, J, 2000) |
Research
Studies (18)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 7 (38.89) | 18.7374 |
1990's | 4 (22.22) | 18.2507 |
2000's | 4 (22.22) | 29.6817 |
2010's | 3 (16.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Bai, M | 1 |
Qi, X | 1 |
Yang, M | 1 |
Han, G | 1 |
Fan, D | 1 |
Kumar, M | 1 |
Kamani, L | 1 |
Hussain, R | 1 |
Siddique, S | 1 |
Abecasis, R | 1 |
Kravetz, D | 1 |
Fassio, E | 1 |
Ameigeiras, B | 1 |
Garcia, D | 1 |
Isla, R | 1 |
Landeira, G | 1 |
Dominguez, N | 1 |
Romero, G | 1 |
Argonz, J | 1 |
Terg, R | 1 |
CHAPIS, NJ | 1 |
Dib, N | 1 |
Oberti, F | 1 |
Calès, P | 1 |
De, BK | 1 |
Dutta, D | 1 |
Som, R | 1 |
Biswas, PK | 1 |
Pal, SK | 1 |
Biswas, A | 1 |
Nevens, F | 2 |
Lijnen, P | 1 |
VanBilloen, H | 1 |
Fevery, J | 1 |
Sugano, S | 1 |
Suzuki, T | 1 |
Nishio, M | 1 |
Makino, H | 1 |
Okajima, T | 1 |
Bosch, J | 1 |
Bou-Abboud, CF | 1 |
Nemec, F | 1 |
Toffel, F | 1 |
Kuntz, E | 1 |
Kommerell, B | 1 |
Felder, KD | 1 |
Wernze, H | 1 |
Brunswig, D | 1 |
Wohlenberg, H | 1 |
Weinreich, J | 1 |
Reviews
6 reviews available for spironolactone and Esophageal and Gastric Varices
Article | Year |
---|---|
Combined therapies versus monotherapies for the first variceal bleeding in patients with high-risk varices: a meta-analysis of randomized controlled trials.
Topics: Combined Modality Therapy; Databases, Bibliographic; Drug Therapy, Combination; Endpoint Determinati | 2014 |
Successful pregnancy outcome in decompensated chronic liver disease with portal vein thrombosis: case report and review of literature.
Topics: Adult; Antiviral Agents; Ascites; Blood Transfusion; Esophageal and Gastric Varices; Female; Hepatit | 2011 |
Bleeding from ruptured oesophageal varices: propranolol for primary prevention.
Topics: Adrenergic beta-Antagonists; Combined Modality Therapy; Diuretics; Endoscopy; Esophageal and Gastric | 2012 |
Current management of the complications of portal hypertension: variceal bleeding and ascites.
Topics: Algorithms; Anti-Bacterial Agents; Ascites; Collateral Circulation; Diuretics; Endoscopy, Gastrointe | 2006 |
The sixth Carlos E. Rubio Memorial Lecture. Prevention and treatment of variceal hemorrhage.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Double-Blind Method; Drug Therapy, Combination | 2000 |
[Hepatogenous (secondary) aldosteronism (author's transl)].
Topics: Aldosterone; Angiotensin II; Chronic Disease; Esophageal and Gastric Varices; Hepatitis; Hepatitis A | 1974 |
Trials
5 trials available for spironolactone and Esophageal and Gastric Varices
Article | Year |
---|---|
Nadolol plus spironolactone in the prophylaxis of first variceal bleed in nonascitic cirrhotic patients: A preliminary study.
Topics: Adrenergic beta-Antagonists; Aged; Double-Blind Method; Drug Therapy, Combination; Esophageal and Ga | 2003 |
Hemodynamic effects of propranolol with spironolactone in patients with variceal bleeds: a randomized controlled trial.
Topics: Adrenergic beta-Antagonists; Adult; Diuretics; Drug Therapy, Combination; Esophageal and Gastric Var | 2008 |
The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Ascites; Atrial Natriuretic Factor; | 1996 |
Non-invasive variceal pressure measurements: validation and clinical implications.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure Determination; Double-Blind Method; Esophageal | 1996 |
Chronic splanchnic hemodynamic effects of low-dose transdermal nitroglycerin versus low-dose transdermal nitroglycerin plus spironolactone in patients with cirrhosis.
Topics: Administration, Cutaneous; Aged; Dose-Response Relationship, Drug; Drug Therapy, Combination; Esopha | 1997 |
Other Studies
7 other studies available for spironolactone and Esophageal and Gastric Varices
Article | Year |
---|---|
PORTACAVAL SHUNT PERFORMED DURING PREGNANCY.
Topics: Chlorothiazide; Diet, Sodium-Restricted; Esophageal and Gastric Varices; Female; Gastrointestinal He | 1964 |
Reversal of andro-genetic alopecia in a male. A spironolactone effect?
Topics: Aged; Alopecia; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Hair; Humans; Liver Cir | 1990 |
[Therapy of liver cirrhosis].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Diet, Sodium-Restricted; Esophageal and Gastric V | 1972 |
[Pregnancy in liver cirrhosis. Internal medicine and gynecological aspects].
Topics: Adult; Ascites; Colon; Diet, Sodium-Restricted; Diuretics; Esophageal and Gastric Varices; Esophagea | 1973 |
Medical grand rounds from the University of Alabama Medical Center.
Topics: Alcoholism; Antacids; Ascites; Biopsy; Blood Transfusion; Collateral Circulation; Esophageal and Gas | 1969 |
[Myelofibrosis and esophageal varices].
Topics: Aged; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Hypertension, Por | 1969 |
[Portal hypertension in chronic liver diseases and its therapy].
Topics: Ascites; Chronic Disease; Esophageal and Gastric Varices; Humans; Hypertension, Portal; Liver Cirrho | 1969 |