Page last updated: 2024-11-07

spironolactone and Epilepsy

spironolactone has been researched along with Epilepsy in 4 studies

Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
" The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures."7.73Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005)
" The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures."3.73Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Johnson, EL1
Kaplan, PW1
Borowicz, KK1
Czuczwar, SJ1
Ross, FM1
Gwyn, P1
Spanswick, D1
Davies, SN1
Mertin, J1
Simon, O1
Schmiedek, P1

Reviews

1 review available for spironolactone and Epilepsy

ArticleYear
Caring for transgender patients with epilepsy.
    Epilepsia, 2017, Volume: 58, Issue:10

    Topics: Androgens; Anti-HIV Agents; Anticonvulsants; Antidepressive Agents; Anxiety Disorders; Comorbidity;

2017

Other Studies

3 other studies available for spironolactone and Epilepsy

ArticleYear
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
    Journal of neural transmission (Vienna, Austria : 1996), 2005, Volume: 112, Issue:7

    Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models

2005
Carbenoxolone depresses spontaneous epileptiform activity in the CA1 region of rat hippocampal slices.
    Neuroscience, 2000, Volume: 100, Issue:4

    Topics: Animals; Carbenoxolone; Depression, Chemical; Epilepsy; Female; Gap Junctions; Hippocampus; Hydrogen

2000
The influence of aldosterone and anticonvulsant drugs on electroencephalographic and clinical disturbances induced by the spirolactone derivative, potassium canrenoate.
    Journal of the neurological sciences, 1975, Volume: 24, Issue:1

    Topics: Aldosterone; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dogs; Electroencepha

1975