spironolactone has been researched along with Endocrine System Diseases in 6 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Endocrine System Diseases: Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperaldosteronism is associated with endothelial dysfunction and impaired vascular reactivity in patients with hypertension or congestive heart failure." | 2.44 | Mineralocorticoid receptor antagonists and endothelial function. ( Leopold, JA; Maron, BA, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maron, BA | 1 |
| Leopold, JA | 1 |
| Tragl, KH | 1 |
| Kawabe, H | 1 |
| Saito, I | 1 |
| Pugeat, M | 1 |
| Nishino, Y | 1 |
| Schröder, H | 1 |
| el Etreby, MF | 1 |
| Siegberg, R | 1 |
| Ylöstalo, P | 1 |
| Laatikainen, T | 1 |
| Pelkonen, R | 1 |
| Stenman, UH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension[NCT05593055] | Phase 4 | 75 participants (Anticipated) | Interventional | 2023-08-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for spironolactone and Endocrine System Diseases
| Article | Year |
|---|---|
Mineralocorticoid receptor antagonists and endothelial function.
Topics: Aldosterone; Animals; Endocrine System Diseases; Endothelium, Vascular; Eplerenone; Humans; Hyperald | 2008 |
[Secondary hypertension].
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calc | 2001 |
[Available anti-androgens for treating skin hyperandrogenism].
Topics: Androgen Antagonists; Androgens; Cyproterone; Cyproterone Acetate; Endocrine System Diseases; Female | 1989 |
1 trial available for spironolactone and Endocrine System Diseases
| Article | Year |
|---|---|
Endocrine and clinical effects of spironolactone in female hyperandrogenism.
Topics: Adult; Amenorrhea; Androgens; Double-Blind Method; Endocrine System Diseases; Female; Gonadotropins, | 1987 |
2 other studies available for spironolactone and Endocrine System Diseases
| Article | Year |
|---|---|
[Iatrogenic and environmentally caused diseases of the endocrine system in the aged].
Topics: Aged; Cortisone; Cushing Syndrome; Digitalis Glycosides; Endocrine System Diseases; Environmental Ex | 1983 |
Experimental studies on the endocrine side effects of new aldosterone antagonists.
Topics: Androgen Antagonists; Animals; Chorionic Gonadotropin; Endocrine System Diseases; Luteinizing Hormon | 1988 |