spironolactone has been researched along with Electrolytes in 112 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Electrolytes: Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Treatment with spironolactone is reported to be useful when combined with loop diuretics and an angiotensin-converting enzyme (ACE) inhibitor in severe congestive heart failure (CHF)." | 9.08 | Effects of spironolactone on exercise capacity and neurohormonal factors in patients with heart failure treated with loop diuretics and angiotensin-converting enzyme inhibitor. ( Endo, A; Furuse, Y; Hisatome, I; Kato, M; Kato, T; Kinugawa, T; Miyakoda, H; Mori, M; Ogino, K; Omodani, H; Osaki, S; Shigemasa, C; Shimoyama, M, 1998) |
| "Torsemide increased sodium excretion substantially in patients with cirrhosis and ascites who were receiving spironolactone." | 9.07 | A dose-response study of orally administered torsemide in patients with ascites due to cirrhosis. ( Applefeld, JJ; Dukes, GE; Hak, LJ; Kasmer, RJ; McClain, CJ; Wermeling, DP, 1994) |
| "The effect of adding spironolactone (Aldactone) on muscle electrolytes was studied in 48 patients with arterial hypertension and/or congestive heart failure who had received conventional diuretic treatment, including a potassium supplement, for more than 1 year." | 9.06 | Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial hypertension. ( Dyckner, T; Wester, PO; Widman, L, 1986) |
| "The aim: To evaluate the effect of single daily 25 mg of spironolactone on serum electrolytes and kidney function tests in patients with severe chronic left sided heart failure." | 8.02 | THE EFFECT OF SPIRONOLACTONE ON SERUM ELECTROLYTES AND RENAL FUNCTION TESTS IN PATIENTS WITH SEVERE CHRONIC HEART FAILURE. ( Abdulzahra, MS; Abdurasool Almedeny, S; Hadi, NR; Yasir Al-Mayah, J, 2021) |
| " Blood pressure, heart rate, concentrations of aldosterone, urea, creatinine, electrolytes, and protein, index of hypertrophy of visceral organs, and 24-h diuresis were evaluated." | 7.74 | Effect of spironolactone on hypertrophy of left ventricular myocardium in wistar rats with experimental uremia. ( Beresneva, ON; Esaian, AM; Karabayeva, AZh; Kayukov, IG; Kotenko, LV; Parastaeva, MM; Sevastyanova, IE, 2008) |
| "Although many new drugs useful in the treatment of congestive heart failure have been introduced during the past 25 years, spironolactone continues to have an important role in the management of this condition." | 7.68 | Spironolactone in the management of congestive heart failure. ( Muller, JE, 1990) |
| "In order to evaluate the relationship between aldosterone status and the blood pressure-lowering effect of spironolactone, 38 patients with essential hypertension were treated with spironolactone (400 mg/day) during one week in hospital on a rigidly sodium-restricted diet." | 7.66 | Role of aldosterone in the antihypertensive effect of spironolactone in essential hypertension. ( Benraad, H; Benraad, T; Drayer, J; Hoefnagels, W; Kloppenborg, P, 1978) |
| "The therapeutic efficacy of 100 mg spironolactone once daily in patients with congestive heart failure was evaluated in a multi-centre study in general practice." | 7.66 | Spironolactone in the long-term management of patients with congestive heart failure. ( Smith, AG, 1980) |
| "Ventricular arrhythmia was recognized as the most common cause of death in this population." | 6.69 | Effect of spironolactone on ventricular arrhythmias in congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy. ( Coelho, O; Gruppi, CJ; Mady, C; Mansur, A; Maranhão, M; Ramires, FJ; Ramires, JA, 2000) |
| "Spironolactone did not produce significant changes in ECF during either the high-Na or low-Na diets." | 5.27 | Effect of spironolactone on fluid volumes and adrenal steroids in primary aldosteronism. ( Hirano, Y; Ichikawa, S; Kogure, M; Matsuo, H; Murata, K; Sakamaki, T; Tajima, Y; Yagi, S, 1984) |
| " Treatment with spironolactone is reported to be useful when combined with loop diuretics and an angiotensin-converting enzyme (ACE) inhibitor in severe congestive heart failure (CHF)." | 5.08 | Effects of spironolactone on exercise capacity and neurohormonal factors in patients with heart failure treated with loop diuretics and angiotensin-converting enzyme inhibitor. ( Endo, A; Furuse, Y; Hisatome, I; Kato, M; Kato, T; Kinugawa, T; Miyakoda, H; Mori, M; Ogino, K; Omodani, H; Osaki, S; Shigemasa, C; Shimoyama, M, 1998) |
| "Torsemide increased sodium excretion substantially in patients with cirrhosis and ascites who were receiving spironolactone." | 5.07 | A dose-response study of orally administered torsemide in patients with ascites due to cirrhosis. ( Applefeld, JJ; Dukes, GE; Hak, LJ; Kasmer, RJ; McClain, CJ; Wermeling, DP, 1994) |
| "The effect of adding spironolactone (Aldactone) on muscle electrolytes was studied in 48 patients with arterial hypertension and/or congestive heart failure who had received conventional diuretic treatment, including a potassium supplement, for more than 1 year." | 5.06 | Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial hypertension. ( Dyckner, T; Wester, PO; Widman, L, 1986) |
| "The aim: To evaluate the effect of single daily 25 mg of spironolactone on serum electrolytes and kidney function tests in patients with severe chronic left sided heart failure." | 4.02 | THE EFFECT OF SPIRONOLACTONE ON SERUM ELECTROLYTES AND RENAL FUNCTION TESTS IN PATIENTS WITH SEVERE CHRONIC HEART FAILURE. ( Abdulzahra, MS; Abdurasool Almedeny, S; Hadi, NR; Yasir Al-Mayah, J, 2021) |
| " Patients with IIH should be evaluated for aldosteronism and considered for spironolactone therapy." | 3.79 | Idiopathic intracranial hypertension associated with either primary or secondary aldosteronism. ( Khalid, H; Khan, MU; Salpietro, V; Weber, KT, 2013) |
| " Blood pressure, heart rate, concentrations of aldosterone, urea, creatinine, electrolytes, and protein, index of hypertrophy of visceral organs, and 24-h diuresis were evaluated." | 3.74 | Effect of spironolactone on hypertrophy of left ventricular myocardium in wistar rats with experimental uremia. ( Beresneva, ON; Esaian, AM; Karabayeva, AZh; Kayukov, IG; Kotenko, LV; Parastaeva, MM; Sevastyanova, IE, 2008) |
| " The lack of therapeutic response to spironolactone, with a good response to amiloride and recurrence of hypertension and metabolic alkalosis after amiloride cessation that was subsequently treated with amiloride, established the diagnosis of Liddle syndrome." | 3.71 | Liddle syndrome in a newborn infant. ( Assadi, FK; Kimura, RE; Patel, S; Subramanian, U, 2002) |
| "Severe dehydration and watery diarrhea were induced by administering diuretics (furosemide, hydrohlorothiazide, spironolactone) and sucrose solution." | 3.70 | Use of peripheral temperature and core-peripheral temperature difference to predict cardiac output in dehydrated calves housed in a thermoneutral environment. ( Constable, PD; Foreman, JH; Morin, DE; Thurmon, JC; Walker, PG, 1998) |
| "5 mL/kg of body weight (BW), PO], sucrose (2 g/kg in a 20% aqueous solution, p." | 3.70 | A reliable, practical, and economical protocol for inducing diarrhea and severe dehydration in the neonatal calf. ( Constable, PD; Drackley, JK; Foreman, JH; Morin, DE; Thurmon, JC; Walker, PG, 1998) |
| " Spironolactone blocked the mineralocorticoid effects of cortisol but not the blood pressure rise, suggesting that these mineralocorticoid effects are not responsible for cortisol-induced hypertension." | 3.69 | Dose-response relationships and mineralocorticoid activity in cortisol-induced hypertension in humans. ( Kelly, JJ; Whitworth, JA; Williamson, PM, 1996) |
| "Although many new drugs useful in the treatment of congestive heart failure have been introduced during the past 25 years, spironolactone continues to have an important role in the management of this condition." | 3.68 | Spironolactone in the management of congestive heart failure. ( Muller, JE, 1990) |
| "This study investigated the anti-mineralocorticoid potency and haemodynamic effects of a series of mineralocorticoid antagonists of the spirolactone type (RU 28318, spironolactone, K-prorenoate, K-canrenoate and canrenone), for their ability to prevent the development of ACTH-induced hypertension in conscious sheep." | 3.67 | Studies on spirolactone steroid antagonists in ACTH-induced hypertension in sheep. ( Coghlan, JP; Reid, AF; Scoggins, BA; Spence, CD; Whitworth, JA, 1989) |
| "Hyperkalemic flaccid quadriplegia and cardiotoxic disturbances developed during antihypertensive therapy with spironolactone in a 76-year-old woman with chronic renal insufficiency." | 3.67 | Successful treatment of hyperkalemic quadriplegia associated with spironolactone. ( Radó, JP, 1988) |
| " Serum electrolytes became normal after spironolactone but not after dexamethasone." | 3.66 | Normotensive primary aldosteronism: report of a case. ( Ikeda, F; Imura, H; Kono, T; Oseko, F; Tanimura, H, 1981) |
| "The therapeutic efficacy of 100 mg spironolactone once daily in patients with congestive heart failure was evaluated in a multi-centre study in general practice." | 3.66 | Spironolactone in the long-term management of patients with congestive heart failure. ( Smith, AG, 1980) |
| "The effect of ethacrynic acid, bumetanide, frusemide, spironolactone and anti-diuretic hormone (ADH) on the urinary and faecal excretion of water and electrolytes by ponies was studied." | 3.66 | The effect of ethacrynic acid, bumetanide, frusemide, spironolactone and ADH on electrolyte excretion in ponies. ( Alexander, F, 1982) |
| "Thirty-two USAF aircrewmen with mild or moderate, uncomplicated essential hypertension were treated with Aldactazide (spironolactone and hydrochlorothiazide)." | 3.66 | Treatment of hypertension in aviators: a clinical trial with Aldactazide. ( Hull, DH; McAfoose, DA; Triebwasser, JH; Wolthuis, RA, 1978) |
| "In order to evaluate the relationship between aldosterone status and the blood pressure-lowering effect of spironolactone, 38 patients with essential hypertension were treated with spironolactone (400 mg/day) during one week in hospital on a rigidly sodium-restricted diet." | 3.66 | Role of aldosterone in the antihypertensive effect of spironolactone in essential hypertension. ( Benraad, H; Benraad, T; Drayer, J; Hoefnagels, W; Kloppenborg, P, 1978) |
| " Five patients with primary aldosteronism due to adenoma were followed during spironolactone treatment, for 35-55 days after the drug had been stopped, and finally, after surgery." | 3.65 | Volume-pressure relationships during development of mineralocorticoid hypertension in man. ( Derkx, FH; Man in 't Veld, AJ; Schalekamp, DH; Verhoeven, RP; Wenting, GH, 1977) |
| "The effect of spironolactone on BP, cardiac output, plasma renin activity and urinary excretion of electrolytes has been studied in 12 hypertensive patients." | 3.65 | The effects of four months' treatment with spironolactone on systemic blood pressure, cardiac output and plasma renin activity in hypertensive patients. ( Bevegård, S; Castenfors, J; Danielson, M, 1977) |
| "candesartan]." | 2.71 | Effect of combined AT1 receptor and aldosterone receptor antagonism on plasminogen activator inhibitor-1. ( Brown, NJ; Kumar, S; Murphey, LJ; Sawathiparnich, P; Vaughan, DE, 2003) |
| "Ventricular arrhythmia was recognized as the most common cause of death in this population." | 2.69 | Effect of spironolactone on ventricular arrhythmias in congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy. ( Coelho, O; Gruppi, CJ; Mady, C; Mansur, A; Maranhão, M; Ramires, FJ; Ramires, JA, 2000) |
| " A significant difference in the tmax values indicates sustained release of furosemide from one of the formulations." | 2.67 | Bioequivalence between two furosemide-spironolactone formulations: a pharmacokinetic and pharmacodynamic approach. ( Blöchl-Daum, B; Eichler, HG; Freissmuth, M; Loew, D; Schütz, W; Tuisl, E, 1991) |
| "In a single-blind, randomized cross-over study the bioavailability of Spironothiazid (50 mg spironolactone, 50 mg hydrochlorothiazide) was investigated in six healthy male volunteers by comparing the same dose of the well-established drugs Aldactone dragees, 50 mg, and Esidrex tablets, 25 mg." | 2.65 | The bioavailability of spironolactone hydrochlorothiazide combination preparation. ( Hitzenberger, G; Horwatitsch, H; Rameis, H, 1982) |
| " 2 In the two collection periods, there were statistically significant log linear dose-response relationships for sodium excretion (P less than 0." | 2.65 | Spironolactone dose-response relationships in healthy subjects. ( Harrison, IR; McInnes, GT; Perkins, RM; Shelton, JR, 1982) |
| " Poor furosemide dosage correlation to serum concentration may indicate variable and poor absorption, especially at higher dosages, advanced disease, or both." | 1.56 | Role of electrolyte concentrations and renin-angiotensin-aldosterone activation in the staging of canine heart disease. ( Adin, D; Atkins, C; Kurtz, K; Papich, MG; Vaden, S, 2020) |
| "Spironolactone treatment also improved cognitive function in ovariectomized-KKAy mice, but failed to improve it in those with administration of estradiol (200 µg/kg per day)." | 1.38 | Improvement of cognitive impairment in female type 2 diabetes mellitus mice by spironolactone. ( Horiuchi, M; Ito, M; Iwanami, J; Jing, F; Min, LJ; Mogi, M; Ohshima, K; Sakata, A; Tsukuda, K, 2012) |
| "Fifteen patients with Bartter's syndrome (hyponatremic hypochloremic hypokalemic metabolic alkalosis) were compared with 15 healthy volunteers." | 1.30 | Membrane ion transport in Bartter's syndrome: evidence for a new syndrome subtype. ( Koren, W; Peleg, E; Postnov, YV; Rosenthal, T, 1997) |
| "Treatment with spironolactone together with potassium led to impressive catch-up growth." | 1.27 | Growth from birth to adulthood in a patient with the neonatal form of Bartter syndrome. ( Massa, G; Proesmans, W; Vanderschueren-Lodeweyckx, M, 1988) |
| "Spironolactone did not produce significant changes in ECF during either the high-Na or low-Na diets." | 1.27 | Effect of spironolactone on fluid volumes and adrenal steroids in primary aldosteronism. ( Hirano, Y; Ichikawa, S; Kogure, M; Matsuo, H; Murata, K; Sakamaki, T; Tajima, Y; Yagi, S, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 80 (71.43) | 18.7374 |
| 1990's | 13 (11.61) | 18.2507 |
| 2000's | 9 (8.04) | 29.6817 |
| 2010's | 8 (7.14) | 24.3611 |
| 2020's | 2 (1.79) | 2.80 |
| Authors | Studies |
|---|---|
| Abdurasool Almedeny, S | 1 |
| Yasir Al-Mayah, J | 1 |
| Abdulzahra, MS | 1 |
| Hadi, NR | 1 |
| Adin, D | 1 |
| Kurtz, K | 1 |
| Atkins, C | 1 |
| Papich, MG | 1 |
| Vaden, S | 1 |
| Thomason, JD | 1 |
| Rapoport, G | 1 |
| Fallaw, T | 1 |
| Calvert, CA | 1 |
| Sun, QL | 1 |
| Li, M | 1 |
| Rui, HL | 1 |
| Chen, YP | 1 |
| Castañeda-Bueno, M | 1 |
| Arroyo, JP | 1 |
| Zhang, J | 1 |
| Puthumana, J | 1 |
| Yarborough, O | 1 |
| Shibata, S | 1 |
| Rojas-Vega, L | 1 |
| Gamba, G | 1 |
| Rinehart, J | 1 |
| Lifton, RP | 1 |
| Karabayeva, AZh | 1 |
| Esaian, AM | 1 |
| Kayukov, IG | 1 |
| Parastaeva, MM | 1 |
| Beresneva, ON | 1 |
| Kotenko, LV | 1 |
| Sevastyanova, IE | 1 |
| Waanders, F | 1 |
| Rienstra, H | 1 |
| Boer, MW | 1 |
| Zandvoort, A | 1 |
| Rozing, J | 1 |
| Navis, G | 1 |
| van Goor, H | 1 |
| Hillebrands, JL | 1 |
| Rafiq, K | 1 |
| Hitomi, H | 1 |
| Nakano, D | 1 |
| Nishiyama, A | 1 |
| Sakata, A | 1 |
| Mogi, M | 1 |
| Iwanami, J | 1 |
| Tsukuda, K | 1 |
| Min, LJ | 1 |
| Jing, F | 1 |
| Ohshima, K | 1 |
| Ito, M | 1 |
| Horiuchi, M | 1 |
| Zhou, X | 1 |
| Crook, MF | 1 |
| Sharif-Rodriguez, W | 1 |
| Zhu, Y | 1 |
| Ruben, Z | 1 |
| Pan, Y | 1 |
| Urosevic-Price, O | 1 |
| Wang, L | 1 |
| Flattery, AM | 1 |
| Forrest, G | 1 |
| Szeto, D | 1 |
| Zhao, H | 1 |
| Roy, S | 1 |
| Forrest, MJ | 1 |
| Costanzo, MR | 1 |
| Heywood, JT | 1 |
| Massie, BM | 1 |
| Iwashita, J | 1 |
| Henderson, L | 1 |
| Mamatsashvili, M | 1 |
| Sisakian, H | 1 |
| Hayrapetyan, H | 1 |
| Sager, P | 1 |
| van Veldhuisen, DJ | 1 |
| Albrecht, D | 1 |
| Khan, MU | 1 |
| Khalid, H | 1 |
| Salpietro, V | 1 |
| Weber, KT | 1 |
| Assadi, FK | 1 |
| Kimura, RE | 1 |
| Subramanian, U | 1 |
| Patel, S | 1 |
| Sawathiparnich, P | 1 |
| Murphey, LJ | 1 |
| Kumar, S | 1 |
| Vaughan, DE | 2 |
| Brown, NJ | 2 |
| DE LUCA, S | 1 |
| KAGAWA, CM | 4 |
| VELASCO, M | 1 |
| KATZ, R | 1 |
| KATZ, E | 1 |
| GARCIA, H | 1 |
| GAZMURI, R | 1 |
| GRIEBLE, HG | 1 |
| JOHNSTON, LC | 1 |
| FULLER, JB | 1 |
| HIRATA, K | 1 |
| HAGIWARA, T | 1 |
| KURODA, H | 1 |
| KATO, E | 1 |
| ASANO, S | 1 |
| AIZAWA, T | 1 |
| MIGHELI, B | 1 |
| PUPITA, F | 1 |
| BERT, G | 1 |
| BIANCO, A | 1 |
| FURMAN, KI | 1 |
| BEER, G | 1 |
| FORLAND, M | 1 |
| PULLMAN, TN | 1 |
| ROSS, EJ | 1 |
| DAVID, M | 1 |
| LASZLO, F | 1 |
| KOVACS, K | 2 |
| DAVID, MA | 1 |
| LASZLO, FA | 1 |
| KENNEDY, GC | 1 |
| HILL, LE | 1 |
| FRIIS-HANSEN, B | 1 |
| SKADHAUGE, E | 1 |
| ZETTERSTROEM, R | 1 |
| SELLER, RH | 1 |
| RAMIREZ-MUXO, O | 1 |
| SWARTZ, C | 1 |
| PITHA, N | 1 |
| BREST, AN | 1 |
| LAAS, H | 1 |
| BETZIEN, G | 1 |
| BRANCHRZ, H | 1 |
| COMOLI, G | 1 |
| GHIRINGHELLI, L | 1 |
| MADULI, S | 1 |
| BELLISARIO, G | 1 |
| CORDOVA, C | 1 |
| LOCOCO, G | 1 |
| NATOLI, A | 1 |
| SANTUCCI, A | 1 |
| AMERIO, A | 1 |
| MATARAZZO, C | 1 |
| LEONDEFF, I | 1 |
| GENTILELAROSA, C | 1 |
| CASCIO, G | 2 |
| PALAZZOADRIANO, M | 2 |
| MELLONI, GF | 1 |
| BARATTA, C | 1 |
| MARANGONI, R | 1 |
| MERLO, L | 1 |
| ANTOGNETTI, R | 1 |
| BARAN, JS | 1 |
| KROL, WF | 1 |
| MAY, CD | 1 |
| RAPP, JP | 1 |
| PERISIC, V | 1 |
| KONECNI, J | 1 |
| BANICEVIC, B | 1 |
| SHIOJI, R | 1 |
| ABE, S | 1 |
| RIKIMARU, S | 1 |
| DRILL, VA | 1 |
| Levy, DG | 1 |
| Rocha, R | 1 |
| Funder, JW | 2 |
| Ma, J | 1 |
| Albornoz, F | 1 |
| Yu, C | 1 |
| Byrne, DW | 1 |
| Nakhoul, F | 1 |
| Khankin, E | 1 |
| Yaccob, A | 1 |
| Kawachi, H | 1 |
| Karram, T | 1 |
| Awaad, H | 1 |
| Nakhoul, N | 1 |
| Hoffman, A | 1 |
| Abassi, Z | 1 |
| Hofmann, LM | 1 |
| Marnane, WG | 1 |
| Tai, YH | 1 |
| Decker, RA | 1 |
| Boedeker, EC | 1 |
| Charney, AN | 1 |
| Donowitz, M | 1 |
| Pisi, E | 1 |
| Marchesini, G | 1 |
| Kono, T | 1 |
| Ikeda, F | 1 |
| Oseko, F | 1 |
| Imura, H | 1 |
| Tanimura, H | 1 |
| McInnes, GT | 4 |
| Shelton, JR | 4 |
| Ramsay, LE | 3 |
| Harrison, IR | 4 |
| Asbury, MJ | 2 |
| Clarke, JM | 2 |
| Perkins, RM | 3 |
| Venning, GR | 2 |
| Ichikawa, S | 1 |
| Tajima, Y | 1 |
| Sakamaki, T | 1 |
| Matsuo, H | 1 |
| Kogure, M | 1 |
| Hirano, Y | 1 |
| Yagi, S | 1 |
| Murata, K | 1 |
| Matzkies, F | 1 |
| Webs, B | 1 |
| Falch, DK | 1 |
| Schreiner, AM | 1 |
| Chan, JC | 1 |
| Cooper, SM | 1 |
| Palmer, RF | 1 |
| Rameis, H | 1 |
| Hitzenberger, G | 1 |
| Horwatitsch, H | 1 |
| Alexander, F | 1 |
| Dux, S | 1 |
| Rosenfeld, J | 1 |
| Cocco, G | 1 |
| Chu, D | 1 |
| Gasser, DF | 1 |
| Hettiarachchi, J | 1 |
| Smith, AG | 1 |
| Applefeld, JJ | 1 |
| Kasmer, RJ | 1 |
| Hak, LJ | 1 |
| Dukes, GE | 1 |
| Wermeling, DP | 1 |
| McClain, CJ | 1 |
| Wenzl, HH | 1 |
| Fine, KD | 1 |
| Santa Ana, CA | 1 |
| Porter, JL | 1 |
| Fordtran, JS | 1 |
| Williamson, PM | 1 |
| Kelly, JJ | 1 |
| Whitworth, JA | 2 |
| Man, SY | 1 |
| Clulow, J | 1 |
| Hansen, LA | 1 |
| Jones, RC | 1 |
| Koren, W | 1 |
| Peleg, E | 1 |
| Rosenthal, T | 1 |
| Postnov, YV | 1 |
| Kinugawa, T | 1 |
| Ogino, K | 1 |
| Kato, M | 1 |
| Furuse, Y | 1 |
| Shimoyama, M | 1 |
| Mori, M | 1 |
| Endo, A | 1 |
| Kato, T | 1 |
| Omodani, H | 1 |
| Osaki, S | 1 |
| Miyakoda, H | 1 |
| Hisatome, I | 1 |
| Shigemasa, C | 1 |
| Constable, PD | 2 |
| Walker, PG | 2 |
| Morin, DE | 2 |
| Foreman, JH | 2 |
| Thurmon, JC | 2 |
| Drackley, JK | 1 |
| Ramires, FJ | 1 |
| Mansur, A | 1 |
| Coelho, O | 1 |
| Maranhão, M | 1 |
| Gruppi, CJ | 1 |
| Mady, C | 1 |
| Ramires, JA | 1 |
| Henger, A | 1 |
| Tutt, P | 1 |
| Riesen, WF | 1 |
| Hulter, HN | 1 |
| Krapf, R | 1 |
| Levy, B | 1 |
| Albert, JP | 1 |
| Wronski, R | 1 |
| Jentzen, F | 1 |
| Hartmann, F | 1 |
| Hull, DH | 1 |
| Wolthuis, RA | 1 |
| Triebwasser, JH | 1 |
| McAfoose, DA | 1 |
| Cordone, G | 1 |
| Fasce, L | 1 |
| Gianfranceschi, P | 1 |
| Delucchi, M | 1 |
| Iester, A | 1 |
| Torcia, R | 1 |
| Benraad, H | 1 |
| Drayer, J | 1 |
| Hoefnagels, W | 1 |
| Kloppenborg, P | 1 |
| Benraad, T | 1 |
| Wenting, GH | 1 |
| Man in 't Veld, AJ | 1 |
| Verhoeven, RP | 1 |
| Derkx, FH | 1 |
| Schalekamp, DH | 1 |
| Bevegård, S | 1 |
| Castenfors, J | 1 |
| Danielson, M | 1 |
| Erbler, HC | 1 |
| Hilfenhaus, M | 1 |
| Schütz, W | 1 |
| Freissmuth, M | 1 |
| Tuisl, E | 1 |
| Blöchl-Daum, B | 1 |
| Eichler, HG | 1 |
| Loew, D | 1 |
| Gatta, A | 1 |
| Angeli, P | 1 |
| Caregaro, L | 1 |
| Menon, F | 1 |
| Sacerdoti, D | 1 |
| Merkel, C | 1 |
| Duclos, B | 1 |
| Bories, P | 1 |
| Mathieu-Daude, JC | 1 |
| Michel, H | 1 |
| Pearce, PT | 1 |
| Myles, K | 1 |
| Roy, LP | 1 |
| Muller, JE | 1 |
| Reid, AF | 1 |
| Coghlan, JP | 1 |
| Spence, CD | 1 |
| Scoggins, BA | 1 |
| Radó, JP | 1 |
| Kushner, RF | 1 |
| Sitrin, MD | 1 |
| Proesmans, W | 1 |
| Massa, G | 1 |
| Vanderschueren-Lodeweyckx, M | 1 |
| Adam, WR | 1 |
| Ellis, AG | 1 |
| Adams, BA | 1 |
| Pockros, PJ | 1 |
| Reynolds, TB | 1 |
| Dyckner, T | 1 |
| Wester, PO | 1 |
| Widman, L | 1 |
| Mertin, J | 1 |
| Koczorek, KR | 1 |
| Backmund, H | 1 |
| Thind, GS | 1 |
| Blakemore, WS | 1 |
| Zinsser, HF | 1 |
| Reimold, EW | 1 |
| Sutherland, LE | 1 |
| Hartroft, P | 1 |
| Balis, JU | 1 |
| Bailey, JD | 1 |
| Lynch, MJ | 1 |
| Vallotton, MB | 1 |
| Scholer, D | 1 |
| Muller, AF | 1 |
| Selye, H | 1 |
| Kaplan, NM | 1 |
| Koppes, G | 1 |
| Lund-Johansen, P | 1 |
| Kaufmann, W | 1 |
| Steiner, B | 1 |
| Dürr, F | 1 |
| Meurer, KA | 1 |
| Behn, C | 1 |
| Griggs, RC | 1 |
| Engel, WK | 1 |
| Resnick, JS | 1 |
| Gentili, G | 1 |
| Liberti, R | 1 |
| Petitier, H | 1 |
| Hua, G | 1 |
| Weiller, M | 1 |
| Faivre, G | 1 |
| Salvetti, A | 1 |
| Cella, PL | 1 |
| Romanelli, R | 1 |
| Gleichmann, U | 1 |
| Bircks, W | 1 |
| Bostroem, B | 1 |
| Kreuzer, H | 1 |
| Spark, RF | 1 |
| Melby, JC | 1 |
| Helmer, OM | 1 |
| Judson, WE | 1 |
| Păunescu-Podanu, A | 1 |
| Demirian, H | 1 |
| Ionitã, C | 1 |
| Georgescu, D | 1 |
| Tarachiu, A | 1 |
| Anghel, R | 1 |
| Rubingher, L | 1 |
| Bianchi, G | 1 |
| Campolo, L | 1 |
| Alè, G | 1 |
| Sala, G | 1 |
| Niall, JF | 1 |
| Pak POY, RK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Renal Ageing-sarcopenia Network: a Combined Genetic, Immunological and Psychological Approach to Dissect Frailty[NCT04630132] | 1,500 participants (Anticipated) | Observational | 2017-03-25 | Recruiting | |||
| A Phase 2, Randomized, Double-Blind, Multi-center Study Comparing CLP Versus Placebo in Heart Failure Patients With Chronic Kidney Disease[NCT01265524] | Phase 2 | 113 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| The Effect of Correction of Metabolic Acidosis in CKD on Intrarenal RAS Activity[NCT02896309] | 45 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Increase in the 6 minute walk test (6MWT) distance from baseline to Week 8. The test was performed according to the American Thoracic Society (ATS)Guidelines 2002. (NCT01265524)
Timeframe: Baseline and 8 weeks
| Intervention | m (Mean) |
|---|---|
| Investigational Drug: CLP | 39.3 |
| Placebo | 19.7 |
Change in serum potassium from baseline to Week 8. (NCT01265524)
Timeframe: Baseline and 8 weeks
| Intervention | mg/dl (Mean) |
|---|---|
| Investigational Drug: CLP | 0.15 |
| Placebo | 0.05 |
The frequency of marked or disabling exertional dyspnea was physician assessed based on physical exam at week 4. (NCT01265524)
Timeframe: 4 weeks
| Intervention | participants (Number) |
|---|---|
| Investigational Drug: CLP | 10 |
| Placebo | 14 |
The frequency of marked or disabling exertional dyspnea was physician assessed based on physical exam at week 8. (NCT01265524)
Timeframe: 8 weeks
| Intervention | participants (Number) |
|---|---|
| Investigational Drug: CLP | 5 |
| Placebo | 12 |
(NCT01265524)
Timeframe: Baseline and 8 weeks
| Intervention | participants (Number) |
|---|---|
| Investigational Drug: CLP | 20 |
| Placebo | 8 |
(NCT01265524)
Timeframe: Baseline and 1 week
| Intervention | kg (Mean) |
|---|---|
| Investigational Drug: CLP | -0.71 |
| Placebo | 0.11 |
(NCT01265524)
Timeframe: Baseline and 2 weeks
| Intervention | kg (Mean) |
|---|---|
| Investigational Drug: CLP | -0.83 |
| Placebo | 0.29 |
2 reviews available for spironolactone and Electrolytes
| Article | Year |
|---|---|
Pathophysiological roles of aldosterone and mineralocorticoid receptor in the kidney.
Topics: Aldosterone; Animals; Blood Pressure; Electrolytes; Eplerenone; Homeostasis; Humans; Kidney; Kidney | 2011 |
Commentary on incidence of primary aldosteronism: current estimations based on objective data.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aldosterone; Blood Pressure; Desoxycorticosterone; | 1969 |
18 trials available for spironolactone and Electrolytes
| Article | Year |
|---|---|
A double-blind, randomized, parallel, placebo-controlled study examining the effect of cross-linked polyelectrolyte in heart failure patients with chronic kidney disease.
Topics: Aged; Aged, 80 and over; Cross-Linking Reagents; Double-Blind Method; Electrolytes; Exercise Test; F | 2012 |
Effect of combined AT1 receptor and aldosterone receptor antagonism on plasminogen activator inhibitor-1.
Topics: Adult; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Diuretics; Electrolytes | 2003 |
Distinguishing the antihypertensive and electrolyte effects of eplerenone.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Electrolytes; Eplerenone; Female; Humans; Hypertensi | 2004 |
Differing effects of mineralocorticoid receptor-dependent and -independent potassium-sparing diuretics on fibrinolytic balance.
Topics: Adult; Cross-Over Studies; Diuretics; Double-Blind Method; Electrolytes; Female; Fibrinolysis; Hemod | 2005 |
Comparison of prorenoate potassium and spironolactone after repeated doses and steady state plasma levels of active metabolites.
Topics: Adolescent; Adult; Electrolytes; Fludrocortisone; Humans; Male; Mineralocorticoids; Potassium; Spiro | 1982 |
Spironolactone dose-response relationships in healthy subjects.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Electrolytes; Fludr | 1982 |
The bioavailability of spironolactone hydrochlorothiazide combination preparation.
Topics: Adult; Antihypertensive Agents; Biological Availability; Drug Combinations; Electrolytes; Humans; Hy | 1982 |
Antagonism of aldosterone in normal subjects by Ro 12-2503 and spironolactone.
Topics: Adult; Creatinine; Diuresis; Double-Blind Method; Drinking; Electrolytes; Enzymes; Hemodynamics; Hum | 1982 |
Spironolactone in thiazide-induced hypokalaemia: variable response between patients.
Topics: Adult; Aldosterone; Benzothiadiazines; Canrenone; Diuretics; Electrolytes; Female; Humans; Hypokalem | 1981 |
A dose-response study of orally administered torsemide in patients with ascites due to cirrhosis.
Topics: Administration, Oral; Adult; Aged; Ascites; Body Weight; Cross-Over Studies; Diuretics; Dose-Respons | 1994 |
Effect of fludrocortisone and spironolactone on sodium and potassium losses in secretory diarrhea.
Topics: Adult; Aldosterone; Body Weight; Cathartics; Diarrhea; Electrolytes; Feces; Female; Fludrocortisone; | 1997 |
Effects of spironolactone on exercise capacity and neurohormonal factors in patients with heart failure treated with loop diuretics and angiotensin-converting enzyme inhibitor.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Diuretics; Echocardiography; Electrolytes; Ex | 1998 |
Effect of spironolactone on ventricular arrhythmias in congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy.
Topics: Analysis of Variance; Antihypertensive Agents; Arrhythmias, Cardiac; Cardiomyopathy, Dilated; Death, | 2000 |
The efficacy and safety of furosemide and a combination of spironolactone and hydrochlorothiazide in congestive heart failure.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Drug Evaluation; Elec | 1977 |
Bioequivalence between two furosemide-spironolactone formulations: a pharmacokinetic and pharmacodynamic approach.
Topics: Adult; Canrenone; Diuresis; Drug Combinations; Drug Evaluation; Electrolytes; Furosemide; Humans; Ma | 1991 |
Effects of spironolactone on serum and muscle electrolytes in patients on long-term diuretic therapy for congestive heart failure and/or arterial hypertension.
Topics: Aged; Blood Pressure; Body Weight; Diuretics; Electrolytes; Female; Heart Failure; Humans; Hypertens | 1986 |
[Combination therapy with spironolactone and polythiazide in hypertension].
Topics: Blood Pressure; Drug Combinations; Electrolytes; Female; Humans; Hypertension; Hypokalemia; Male; Mi | 1971 |
Acetazolamide treatment of hypokalemic periodic paralysis. Prevention of attacks and improvement of persistent weakness.
Topics: Acetazolamide; Acidosis; Adult; Child; Electrolytes; Female; Humans; Hypokalemia; Male; Middle Aged; | 1970 |
92 other studies available for spironolactone and Electrolytes
| Article | Year |
|---|---|
THE EFFECT OF SPIRONOLACTONE ON SERUM ELECTROLYTES AND RENAL FUNCTION TESTS IN PATIENTS WITH SEVERE CHRONIC HEART FAILURE.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Diuretics; Electrolytes; | 2021 |
Role of electrolyte concentrations and renin-angiotensin-aldosterone activation in the staging of canine heart disease.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diuretics; Dog Diseases; Dogs; Electrolytes; Hear | 2020 |
The influence of enalapril and spironolactone on electrolyte concentrations in Doberman pinschers with dilated cardiomyopathy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomyopathy, Dilated; Cohort Studies; Dog Dise | 2014 |
Inhibition of local aldosterone by eplerenone reduces renal structural damage in a novel model of chronic cyclosporine A nephrotoxicity.
Topics: Adrenalectomy; Aldosterone; Animals; Chronic Disease; Cyclosporine; Cytochrome P-450 CYP11B2; Diseas | 2015 |
Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.
Topics: Angiotensin II; Animals; Blood Volume; Chlorocebus aethiops; COS Cells; Cyclic AMP-Dependent Protein | 2017 |
Effect of spironolactone on hypertrophy of left ventricular myocardium in wistar rats with experimental uremia.
Topics: Aldosterone; Animals; Creatinine; Electrolytes; Hypertrophy, Left Ventricular; Kidney Failure, Chron | 2008 |
Spironolactone ameliorates transplant vasculopathy in renal chronic transplant dysfunction in rats.
Topics: Animals; Blood Pressure; Body Weight; Chronic Disease; Creatinine; Delayed Graft Function; Disease M | 2009 |
Improvement of cognitive impairment in female type 2 diabetes mellitus mice by spironolactone.
Topics: Animals; Blood Pressure; Body Weight; Cognition Disorders; Diabetes Mellitus, Type 2; Electrolytes; | 2012 |
Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension.
Topics: Aldosterone; Animals; Blood Pressure; Chronic Disease; Creatinine; Disease Models, Animal; Disease P | 2011 |
Idiopathic intracranial hypertension associated with either primary or secondary aldosteronism.
Topics: Adolescent; Adult; Aldosterone; Child; Electrolytes; Female; Humans; Hyperaldosteronism; Male; Middl | 2013 |
Liddle syndrome in a newborn infant.
Topics: Alkalosis; Amiloride; Blood Pressure; Diuretics; Electrolytes; Failure to Thrive; Female; Humans; Hy | 2002 |
[On the behavior of diuresis and serum and urinary electrolytes during treatment with spirolactone (Sc-9420) in menopausal women].
Topics: Diuresis; Electrolytes; Female; Humans; Lactones; Menopause; Spironolactone; Urinary Tract | 1960 |
Steroidal spirolactones and renal function.
Topics: Aldosterone; Diuretics; Electrolytes; Humans; Kidney; Mineralocorticoid Receptor Antagonists; Pregna | 1960 |
[Effect of SC 9420, mercurial diuretic and hydrochlorothiazide on electrolyte excretion in liver cirrhosis].
Topics: Aldosterone; Chlorothiazide; Diuretics; Electrolytes; Humans; Hydrochlorothiazide; Liver Cirrhosis; | 1959 |
Treatment of arterial hypertensive disease with diuretics. II. Effects on electrolytes and uric acid of bendroflumethiazide, potassium chloride, and spironolactone.
Topics: Bendroflumethiazide; Diuretics; Electrolytes; Humans; Hypertension; Potassium Chloride; Spironolacto | 1962 |
Studies on water and electrolyte-regularing hormones. I. Clinical obervations of the diuretic effects of acth, glucocorticoids, adrenal cortical inhibitor, amphenone or aldosterone antagonist, SC-9420.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Diuretics; Edetic Acid; Electrolytes; Glucocorticoids; | 1962 |
[Modifications of renal function, water space and electrolyte metabolism induced by spironolactone in the normal subject].
Topics: Electrolytes; Humans; Kidney; Spironolactone; Water; Water-Electrolyte Balance | 1962 |
Dynamic changes in sweat electrolyte composition induced by heat stress as an indication of acclimatization and aldosterone activity.
Topics: Acclimatization; Aldosterone; Electrolytes; Heat Stress Disorders; Hot Temperature; Humans; Ions; Po | 1963 |
Electrolyte complications of drug therapy.
Topics: Alkalosis; Anatomy; Carbonic Anhydrases; Diuretics; Electrolytes; Estrogens; Humans; Hypercalcemia; | 1963 |
Human assay of electrolyte-active steroids and their antagonists.
Topics: Aldosterone; Electrolytes; Fludrocortisone; Humans; Potassium; Pterins; Sodium; Sodium, Dietary; Spi | 1962 |
[The role of the pituitary in the effect of spironolactone on water and electrolyte diuresis].
Topics: Diuresis; Electrolytes; Humans; Pituitary Diseases; Pituitary Gland; Spironolactone; Water; Water-El | 1963 |
The role of the pituitary in the effect of spironolactone on water and electrolyte excretion.
Topics: Body Fluids; Electrolytes; Hypophysectomy; Pituitary Diseases; Pituitary Gland; Spironolactone; Wate | 1962 |
Electrolyte conservation during the treatment of diabetes insipidus with benzothiadiazines.
Topics: Benzothiadiazines; Diabetes Insipidus; Diabetes Mellitus; Diuresis; Electrolytes; Humans; Hydroflume | 1963 |
FLUID AND ELECTROLYTE METABOLISM IN NEPHROGENIC DIABETES INSIPIDUS.TWO CASES.
Topics: Bendroflumethiazide; Child; Diabetes Insipidus; Diabetes Insipidus, Nephrogenic; Diabetes Insipidus, | 1963 |
SPIROLACTONE EFFECT ON POSTOPERATIVE ELECTROLYTES AND ADRENAL ACTIVITY.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Chlorides; Creatine; Creatinine; Electrolytes; Humans; Hyp | 1963 |
[ON THE ANTIHYPERTENSIVE EFFECT OF THE SUBSTANCES ISOBUTYLHYDROCHLOROTHIAZIDE, SPIRONOLACTONE AND TRIAMTERENE ACTING ON ELECTROLYTES].
Topics: Antihypertensive Agents; Diuretics; Electrolytes; Geriatrics; Humans; Hydrochlorothiazide; Hypertens | 1963 |
[DIURETIC THERAPY OF DECOMPENSATED HEPATIC CIRRHOSIS].
Topics: Blood Chemical Analysis; Chlorothiazide; Chlorthalidone; Diuresis; Diuretics; Electrolytes; Humans; | 1963 |
[PRELIMINARY RESULTS OF THE USE OF SPIROLACTONE IN PATIENTS WITH CIRCULATORY INSUFFICIENCY].
Topics: Body Weight; Diuresis; Electrolytes; Heart Failure; Humans; Pericarditis; Pericarditis, Constrictive | 1963 |
[CHANGES OF THE ALDOSTERONE EFFECT INDUCED BY SPIRONOLACTONE AND TRIAMTERENE. STUDY OF THE POSSIBLE MECHANISM OF ACTION].
Topics: Aldosterone; Diuretics; Electrolytes; Erythrocytes; Pharmacology; Pterins; Rats; Research; Spironola | 1963 |
[PHARMACOLOGICAL ACTIONS OF 2 HETEROCYCLIC GLYOXYLIC ALDEHYDES WITH NOTABLE DIURETIC ACTIVITY].
Topics: Aldehydes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorothiazide; C | 1964 |
[ON MODIFICATIONS OF PLASMA AND URINARY ELECTROLYTES IN ASCITOGENIC HEPATIC CIRRHOSIS IN TREATMENT WITH TRIAMTERENE ALONE AND ASSOCIATED WITH HYDROCHLOROTHIAZIDE AND WITH SPIRONOLACTONE].
Topics: Ascites; Biomedical Research; Chlorides; Electrolytes; Geriatrics; Humans; Hydrochlorothiazide; Live | 1964 |
URINARY ELECTROLYTE EFFECTS OF OUABAIN AND OUABAGENIN IN ADRENALECTOMIZED RATS.
Topics: Adrenalectomy; Chlorides; Diuresis; Diuretics; Electrolytes; Natriuresis; Ouabain; Pharmacology; Pot | 1964 |
ELECTROLYTE EXCRETION BY SWEAT GLANDS AND KIDNEYS DURING SUPPRESSION OF ADRENAL CORTICOSTEROID ACTIVITY BY METHOPYRAPONE AND SPIRONOLACTONE.
Topics: Adrenal Cortex Hormones; Biomedical Research; Body Fluids; Chlorides; Dexamethasone; Electrolytes; I | 1965 |
EFFECT OF AN ALDOSTERONE ANTAGONIST ON ELECTROLYTES AND JUXTAGLOMERULAR GRANULARITY IN ADRENAL REGENERATION HYPERTENSION.
Topics: Adrenal Glands; Angiotensins; Blood; Blood Pressure; Electrolytes; Hypertension; Juxtaglomerular App | 1964 |
[EFFECT OF A SPIRONOLACTONE ALDOSTERONE INHIBITOR AND CHLOROTHIAZIDE ON WATER AND ELECTROLYTE EXCRETION IN LIVER DISEASES].
Topics: Aldosterone; Biomedical Research; Body Fluids; Chlorothiazide; Electrolytes; Liver Diseases; Mineral | 1964 |
[CHARACTERIZATION OF THE DIURETIC EFFECT OF COUMARIN-3-GLYOXYLIC ALDEHYDE].
Topics: Aldehydes; Aldosterone; Body Fluids; Carbon Tetrachloride; Chlorothiazide; Coumarins; Diuretics; Ele | 1963 |
EFFECTS OF SALT RESTRICTION, SPIRONOLACTONE, AND AMMONIUM CHLORIDE ON ACID-BASE RELATIONS IN A CASE OF PRIMARY ALDOSTERONISM.
Topics: Acid-Base Equilibrium; Adrenal Gland Neoplasms; Alkalosis; Ammonium Chloride; Blood; Diet, Sodium-Re | 1965 |
Blocking the renal electrolyte effects of mineralocorticoids with an orally active steroidal spirolactone.
Topics: Adrenal Cortex Hormones; Electrolytes; Humans; Kidney; Lactones; Mineralocorticoids; Spironolactone | 1960 |
Influence of spironolactone in modifying the renal electrolyte effects of hydrochlorothiazide in laboratory animals.
Topics: Aldosterone; Animals; Animals, Laboratory; Chlorothiazide; Electrolytes; Hydrochlorothiazide; Kidney | 1962 |
Eplerenone potentiates the antiproteinuric effects of enalapril in experimental nephrotic syndrome.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Blood Urea Nitrogen; | 2008 |
Azido pyrimidine diuretics (SC-16102, SC-16100): ADH antagonism assay in the rat.
Topics: Animals; Diuretics; Electrolytes; Furosemide; Hydrochlorothiazide; Male; Prednisone; Pyrimidines; Ra | 1967 |
Methylprednisolone stimulation of guanylate cyclase activity in rat small intestinal mucosa: possible role in electrolyte transport.
Topics: Animals; Biological Transport; Colon; Cyclic AMP; Cyclic GMP; Desoxycorticosterone; Electrolytes; Gu | 1981 |
[Hepatic coma. Therapeutic aspects].
Topics: Amino Acids; Bromocriptine; Electrolytes; Furosemide; Glucose; Hepatic Encephalopathy; Histamine H2 | 1984 |
Normotensive primary aldosteronism: report of a case.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Angiotensin II | 1981 |
Relative potency and structure activity relationships of aldosterone antagonists in healthy man: correlation with animal experience.
Topics: Animals; Double-Blind Method; Electrolytes; Humans; Mineralocorticoid Receptor Antagonists; Receptor | 1982 |
Effect of spironolactone on fluid volumes and adrenal steroids in primary aldosteronism.
Topics: Adrenal Cortex Hormones; Adult; Aged; Blood Pressure; Diet, Sodium-Restricted; Electrolytes; Extrace | 1984 |
[Electrolyte excretion following administration of various diuretics in healthy females].
Topics: Bendroflumethiazide; Circadian Rhythm; Diuretics; Drug Therapy, Combination; Electrolytes; Female; F | 1984 |
Changes in urinary electrolytes versus serum electrolytes during treatment of primary hypertension with chlorthalidone alone and in combination with spironolactone.
Topics: Adult; Aldosterone; Chlorthalidone; Drug Therapy, Combination; Electrolytes; Humans; Hypertension; M | 1981 |
Bartter's syndrome.
Topics: Aldosterone; Bartter Syndrome; Brain Diseases, Metabolic; Child, Preschool; Electrolytes; Humans; Hy | 1981 |
The effect of ethacrynic acid, bumetanide, frusemide, spironolactone and ADH on electrolyte excretion in ponies.
Topics: Animals; Body Water; Bumetanide; Chlorides; Diuretics; Electrolytes; Ethacrynic Acid; Furosemide; Ho | 1982 |
Bioassay of a new aldosterone antagonist and evaluation of a simple method of quantitative comparison.
Topics: Double-Blind Method; Electrolytes; Fludrocortisone; Humans; Male; Mineralocorticoid Receptor Antagon | 1981 |
Spironolactone in the long-term management of patients with congestive heart failure.
Topics: Aged; Edema, Cardiac; Electrolytes; Female; Heart Failure; Humans; Male; Spironolactone | 1980 |
Dose-response relationships and mineralocorticoid activity in cortisol-induced hypertension in humans.
Topics: Adult; Blood Pressure; Dose-Response Relationship, Drug; Electrolytes; Humans; Hydrocortisone; Hyper | 1996 |
Adrenal independence of fluid and electrolyte reabsorption in the ductuli efferentes testis of the rat.
Topics: Adrenal Glands; Adrenalectomy; Aldosterone; Animals; Body Fluids; Ejaculatory Ducts; Electrolytes; M | 1997 |
Membrane ion transport in Bartter's syndrome: evidence for a new syndrome subtype.
Topics: Adolescent; Adult; Bartter Syndrome; Biological Transport; Calcium; Calmodulin; Carrier Proteins; Ch | 1997 |
Use of peripheral temperature and core-peripheral temperature difference to predict cardiac output in dehydrated calves housed in a thermoneutral environment.
Topics: Animals; Animals, Newborn; Blood Pressure; Body Temperature; Cardiac Output; Cattle; Cattle Diseases | 1998 |
A reliable, practical, and economical protocol for inducing diarrhea and severe dehydration in the neonatal calf.
Topics: Animals; Animals, Newborn; Blood Glucose; Blood Proteins; Body Temperature; Body Weight; Cattle; Col | 1998 |
Acid-base and endocrine effects of aldosterone and angiotensin II inhibition in metabolic acidosis in human patients.
Topics: Acid-Base Equilibrium; Acidosis; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Chronic D | 2000 |
[Plasma aldosterone and electrolytes in primary and secondard aldosteronism (author's transl)].
Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Aldosterone; Ascites; Electrolytes; Female; Humans; Hypera | 1979 |
Treatment of hypertension in aviators: a clinical trial with Aldactazide.
Topics: Adult; Aerospace Medicine; Blood Volume; Drug Combinations; Electrolytes; Humans; Hydrochlorothiazid | 1978 |
[Bartter's syndrome. Current prospects of nosographic classification and new therapeutic possibilities].
Topics: Aldosterone; Bartter Syndrome; Child; Electrolytes; Female; Humans; Hyperaldosteronism; Indomethacin | 1978 |
Role of aldosterone in the antihypertensive effect of spironolactone in essential hypertension.
Topics: Adult; Aldosterone; Blood Pressure; Body Weight; Electrolytes; Female; Humans; Hypertension; Kidney; | 1978 |
Volume-pressure relationships during development of mineralocorticoid hypertension in man.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Insufficiency; Blood Pressure; Blood Volume; Electrolytes; | 1977 |
The effects of four months' treatment with spironolactone on systemic blood pressure, cardiac output and plasma renin activity in hypertensive patients.
Topics: Adult; Blood Pressure; Blood Volume; Cardiac Output; Electrolytes; Female; Humans; Hypertension; Mal | 1977 |
Proceedings: Acute and chronic effects of the aldosterone antagonist spironolactone and its main metabolite canrenone on plasma aldosterone concentration, plasma renin activity, serum electrolytes and on the excretion of aldosterone, fluid and electrolyte
Topics: Aldosterone; Animals; Canrenone; Electrolytes; Male; Pregnadienes; Rats; Renin; Spironolactone | 1975 |
A pathophysiological interpretation of unresponsiveness to spironolactone in a stepped-care approach to the diuretic treatment of ascites in nonazotemic cirrhotic patients.
Topics: Adult; Aged; Aged, 80 and over; Aldosterone; Ascites; Diuretics; Drug Resistance; Electrolytes; Fema | 1991 |
Jejunal permeability to water and electrolytes in patients with chronic intrahepatic hypertension: evidence for a role of aldosterone.
Topics: Adult; Aged; Aldosterone; Chlorides; Electrolytes; Female; Humans; Hypertension, Portal; Intestinal | 1991 |
Apparent mineralocorticoid excess, pseudohypoaldosteronism, and urinary electrolyte excretion: toward a redefinition of mineralocorticoid action.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adrenalectomy; Aldosterone; Androstanols; Animals; Bicarbonat | 1990 |
Spironolactone in the management of congestive heart failure.
Topics: Diuretics; Drug Therapy, Combination; Electrolytes; Heart Failure; Humans; Kidney Tubules; Spironola | 1990 |
Studies on spirolactone steroid antagonists in ACTH-induced hypertension in sheep.
Topics: Adrenocorticotropic Hormone; Animals; Blood Pressure; Chemical Phenomena; Chemistry; Electrolytes; F | 1989 |
Successful treatment of hyperkalemic quadriplegia associated with spironolactone.
Topics: Acid-Base Equilibrium; Aged; Aldosterone; Blood Glucose; Electrocardiography; Electrolytes; Female; | 1988 |
Metabolic acidosis. Development in two patients receiving a potassium-sparing diuretic and total parenteral nutrition.
Topics: Acidosis; Adult; Aged; Electrolytes; Female; Humans; Kidney; Parenteral Nutrition, Total; Spironolac | 1986 |
Growth from birth to adulthood in a patient with the neonatal form of Bartter syndrome.
Topics: Adolescent; Adult; Bartter Syndrome; Calcium; Child; Child, Preschool; Diuresis; Electrolytes; Femal | 1988 |
Aldosterone is a physiologically significant kaliuretic hormone.
Topics: Adrenalectomy; Aldosterone; Animals; Electrolytes; Female; Homeostasis; Potassium; Rats; Rats, Inbre | 1987 |
Rapid diuresis in patients with ascites from chronic liver disease: the importance of peripheral edema.
Topics: Amiloride; Ascites; Body Weight; Chronic Disease; Diuresis; Edema; Electrolytes; Furosemide; Humans; | 1986 |
[Pilot study on the efficacy of high doses of aldosterone and spirolactone derivatives in the treatment of multiple sclerosis].
Topics: Adult; Aldosterone; Blood Pressure Determination; Body Weight; Chronic Disease; Electrocardiography; | 1972 |
Direct current cardioversion in digitalized patients with mitral valve disease.
Topics: Adult; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Bradycardia; Cardiac Complexes, Pr | 1969 |
[Angiotensin and saluretics in nephrogenic diabetes insipidus of early infancy].
Topics: Angiotensin II; Body Temperature; Chlorthalidone; Diabetes Insipidus; Electrolytes; Female; Furosemi | 1967 |
Bartter's syndrome. A report of four cases, including three in one sibship, with comparative histologic evaluation of the juxtaglomerular apparatuses and glomeruli.
Topics: Alkalosis; Angiotensin II; Blood Pressure; Carbon Dioxide; Cerebrospinal Fluid Proteins; Electrolyte | 1970 |
[The renin-angiotensin-aldosterone system. Disorders and methods of clinical research].
Topics: Adrenal Gland Neoplasms; Adrenal Insufficiency; Aldosterone; Angiotensin II; Dexamethasone; Electrol | 1970 |
Spironolactone actions, independent of mineralocorticoid blockade.
Topics: Anesthetics; Animals; Depression, Chemical; Desoxycorticosterone; Digitoxin; Electrolytes; Female; K | 1969 |
Primary aldosteronism. Review of diagnostic tests and 15 cases.
Topics: Academic Dissertations as Topic; Adult; Aged; Aldosterone; Diagnosis, Differential; Electrolytes; Ev | 1972 |
[Induced aldosteronism in hydropic heart insufficiency].
Topics: Acid-Base Equilibrium; Adult; Aged; Aldosterone; Body Weight; Carbon Isotopes; Cardiac Glycosides; E | 1969 |
[Clinical study of the use of "Spirolang" 50].
Topics: Adult; Aged; Ascites; Chronic Disease; Digitalis Glycosides; Diuresis; Electrolytes; Ethacrynic Acid | 1971 |
[Chronic cardiac insufficiency and ventricular hyperexcitability: value of unjectable anti-aldosterone with quick action].
Topics: Adult; Aged; Diuresis; Electrolytes; Female; Heart Failure; Humans; Injections, Intramuscular; Injec | 1971 |
[Spironolactone test in the diagnosis of primary and secondary hyperaldosteronism in renal ischemia].
Topics: Adolescent; Adult; Electrolytes; Female; Humans; Hyperaldosteronism; Hypertension, Renal; Male; Midd | 1967 |
[Studies on the effect of the aldosterone-antagonist aldadeine-potassium on secondary aldosteronism after surgery with the heart-lung machine].
Topics: Acid-Base Equilibrium; Adult; Cardiac Surgical Procedures; Diuresis; Electrolytes; Erythrocytes; Hea | 1967 |
Aldosteronism in hypertension. The spironolactone response test.
Topics: Adrenalectomy; Aldosterone; Blood Pressure; Body Weight; Diagnosis, Differential; Electrolytes; Huma | 1968 |
Metabolic studies on hypertensive patients with suppressed plasma renin activity not due to hyperaldosternosm.
Topics: Adult; Aldosterone; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Blood Volume; Body Weight; E | 1968 |
[Clinical and biochemical study of the therapeutic effect of the diuretic triamterene in ascitogenic cirrhosis].
Topics: Adrenal Cortex Hormones; Ascites; Diuresis; Electrolytes; Humans; Hydrochlorothiazide; Liver Cirrhos | 1968 |
[Primary hyperaldosteronism. Description of a clinical case].
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Gland Neoplasms; Adult; Alkalosis; Electrolytes; | 1969 |
Studies in familial hypokalaemic periodic paralysis.
Topics: Adult; Aldosterone; Blood Chemical Analysis; Chlorides; Diet, Sodium-Restricted; Diuresis; Electroly | 1966 |