spironolactone has been researched along with Edema, Cardiac in 12 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Edema, Cardiac: Abnormal fluid retention by the body due to impaired cardiac function or heart failure. It is usually characterized by increase in venous and capillary pressure, and swollen legs when standing. It is different from the generalized edema caused by renal dysfunction (NEPHROTIC SYNDROME).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic efficacy of 100 mg spironolactone once daily in patients with congestive heart failure was evaluated in a multi-centre study in general practice." | 7.66 | Spironolactone in the long-term management of patients with congestive heart failure. ( Smith, AG, 1980) |
| "The efficacy and tolerability of two combinations, namely 50 mg spironolactone + 20 mg furosemide (SF) or 50 mg spironolactone + 5 mg butizide (SB), were compared in a randomised intraindividual trial in 22 patients with congestive heart failure." | 5.05 | [Comparative study of 2 diuretic-containing combination preparations in patients with edematous heart failure]. ( Ehrlich, E; Mauersberger, H; Rangoonwala, B, 1985) |
| "The therapeutic efficacy of 100 mg spironolactone once daily in patients with congestive heart failure was evaluated in a multi-centre study in general practice." | 3.66 | Spironolactone in the long-term management of patients with congestive heart failure. ( Smith, AG, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MARSICO, F | 1 |
| DE FILIPPIS, V | 1 |
| PEDICINI, S | 1 |
| VIALA, JJ | 1 |
| FATH, A | 1 |
| STRATA, A | 1 |
| PREIS, H | 1 |
| JAKOBSON, T | 1 |
| ANDRIEU, J | 1 |
| PEYRIDIEUX, R | 1 |
| ISORNI, P | 1 |
| SETTEL, E | 1 |
| LEPPLA, W | 1 |
| TIEFENSEE, H | 1 |
| Davies, IB | 1 |
| Lightman, SL | 1 |
| Smith, AG | 1 |
| Ehrlich, U | 1 |
| Klepzig, H | 1 |
| Marone, C | 1 |
| Beretta-Piccoli, C | 1 |
| Weidmann, P | 1 |
| Mauersberger, H | 1 |
| Rangoonwala, B | 1 |
| Ehrlich, E | 1 |
1 review available for spironolactone and Edema, Cardiac
| Article | Year |
|---|---|
Refractory oedema.
Topics: Aminophylline; Bumetanide; Diuretics; Drug Therapy, Combination; Edema; Edema, Cardiac; Ethacrynic A | 1980 |
1 trial available for spironolactone and Edema, Cardiac
| Article | Year |
|---|---|
[Comparative study of 2 diuretic-containing combination preparations in patients with edematous heart failure].
Topics: Aged; Diuretics; Drug Combinations; Edema, Cardiac; Female; Furosemide; Heart Failure; Humans; Hydro | 1985 |
10 other studies available for spironolactone and Edema, Cardiac
| Article | Year |
|---|---|
[First results obtained with the use of the spirolactone SC-9420 (aldactone) in the treatment of cardiac edema].
Topics: Edema, Cardiac; Heart Failure; Lactones; Spironolactone | 1960 |
[Apparently irreducible cardiac edema. Remarkable effect of a spirolactone].
Topics: Aldosterone; Diuretics; Edema, Cardiac; Heart Failure; Mineralocorticoid Receptor Antagonists; Spiro | 1961 |
[Diuretic and saluretic action of an aldosterone antagonist (spirolactone, SC-9420) associated with an iso-indoline derivative (Hygroton) in refractory cardiac edema].
Topics: Aldosterone; Antihypertensive Agents; Chlorthalidone; Diuretics; Edema, Cardiac; Heart Failure; Indo | 1962 |
[Aldosterone antagonists in the treatment of cardiac edema].
Topics: Edema, Cardiac; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Progesterone; Spirono | 1962 |
[Treatment of 12 cases of so-called irreversible cardiac edemas by the antagonistic aldosterone medication].
Topics: Aldosterone; Edema, Cardiac; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Spironol | 1963 |
FURTHER EXPERIENCE WITH SPIRONOLACTONE-HYDRO-CHLOROTHIAZIDE (ALDACTAZIDE-A) IN THE LONG-TERM TREATMENT OF REFRACTORY CARDIAC EDEMA.
Topics: Arteriosclerosis; Chlorothiazide; Coronary Disease; Drug Combinations; Drug Therapy; Edema; Edema, C | 1965 |
[Aldostegone-antagonistic steroids as diuretics. Spironolactone in the treatment of hepatic and cardiac edemas].
Topics: Aldosterone; Diuretics; Edema, Cardiac; Edetic Acid; Heart Failure; Liver Cirrhosis; Mineralocortico | 1961 |
Spironolactone in the long-term management of patients with congestive heart failure.
Topics: Aged; Edema, Cardiac; Electrolytes; Female; Heart Failure; Humans; Male; Spironolactone | 1980 |
[Long term therapy over nine years with Spironolacton in hydropic cardiac insufficiency].
Topics: Aged; Blood Pressure; Body Weight; Cardiac Glycosides; Cardiomegaly; Diuretics; Drug Therapy, Combin | 1976 |
[Basis and clinical aspects of diuretic drug therapy].
Topics: Acetazolamide; Benzothiadiazines; Diuretics; Edema; Edema, Cardiac; Furosemide; Glaucoma; Humans; Hy | 1979 |