spironolactone has been researched along with Disease in 3 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Disease: A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.
| Excerpt | Relevance | Reference |
|---|---|---|
| " On comparison of the pharmacokinetic parameters with the respective values of a control group of younger healthy female subjects, the serum concentrations in the elderly patients were found to be twice as high." | 1.27 | The influence of age and multimorbidity on the pharmacokinetics and metabolism of spironolactone. ( Abshagen, U; Horn, HJ; Mühlberg, W; Platt, D; Schmitt-Rüth, R; Vollmar, J, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LUPULESCU, A | 1 |
| Hoff, F | 1 |
| Platt, D | 1 |
| Abshagen, U | 1 |
| Mühlberg, W | 1 |
| Horn, HJ | 1 |
| Schmitt-Rüth, R | 1 |
| Vollmar, J | 1 |
3 other studies available for spironolactone and Disease
| Article | Year |
|---|---|
Effects of an aldosterone-antagonist (SC-8109) on radio-sodium (Na22) metabolism in rats with hypothalamic lesions.
Topics: Aldosterone; Animals; Antihypertensive Agents; Disease; Diuretics; Hormone Antagonists; Hypothalamus | 1961 |
[Instinctive food selection as a disease-regulating factor].
Topics: Appetite; Autonomic Nervous System; Disease; Female; Food; Humans; Hunger; Hyperaldosteronism; Hypoc | 1966 |
The influence of age and multimorbidity on the pharmacokinetics and metabolism of spironolactone.
Topics: Aged; Aging; Blood Proteins; Canrenone; Chromatography, High Pressure Liquid; Disease; Erythrocyte C | 1984 |