spironolactone has been researched along with Disbacteriosis in 1 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study analyzes whether the mineralocorticoid receptor antagonist spironolactone ameliorates the dysbiosic state in a genetic model of neurogenic hypertension." | 5.69 | Mineralocorticoid receptor blockade improved gut microbiota dysbiosis by reducing gut sympathetic tone in spontaneously hypertensive rats. ( Duarte, J; Gómez-Guzmán, M; González-Correa, C; Jiménez, R; Martín-Morales, N; Miñano, S; Moleón, J; O'Valle, F; Robles-Vera, I; Romero, M; Sánchez, M; Toral, M, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| González-Correa, C | 1 |
| Moleón, J | 1 |
| Miñano, S | 1 |
| Robles-Vera, I | 1 |
| Toral, M | 1 |
| Martín-Morales, N | 1 |
| O'Valle, F | 1 |
| Sánchez, M | 1 |
| Gómez-Guzmán, M | 1 |
| Jiménez, R | 1 |
| Romero, M | 1 |
| Duarte, J | 1 |
1 trial available for spironolactone and Disbacteriosis
| Article | Year |
|---|---|
Mineralocorticoid receptor blockade improved gut microbiota dysbiosis by reducing gut sympathetic tone in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Dysbiosis; Gastrointestinal Microbiome; Hypertension; Male; Rats; Rats, Inb | 2023 |