spironolactone has been researched along with Diabetes Insipidus in 28 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Diabetes Insipidus: A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated the effects of 7-day aldosterone infusion or oral spironolactone treatment on water balance and aquaporin (AQP) 2 expression in rats with 21 days of lithium-induced nephrogenic diabetes insipidus (Li-NDI)." | 7.73 | Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus. ( Frøkiaer, J; Knepper, MA; Kwon, TH; Nielsen, J; Nielsen, S; Praetorius, J, 2006) |
| " We investigated the effects of 7-day aldosterone infusion or oral spironolactone treatment on water balance and aquaporin (AQP) 2 expression in rats with 21 days of lithium-induced nephrogenic diabetes insipidus (Li-NDI)." | 3.73 | Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus. ( Frøkiaer, J; Knepper, MA; Kwon, TH; Nielsen, J; Nielsen, S; Praetorius, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (92.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, MZ | 1 |
| Hao, CM | 1 |
| Breyer, MD | 1 |
| Harris, RC | 1 |
| McKanna, JA | 1 |
| GARAGNANI, A | 1 |
| SURIANI, L | 1 |
| BRILLANTE, C | 1 |
| KENNEDY, GC | 1 |
| HILL, LE | 1 |
| FRIIS-HANSEN, B | 1 |
| SKADHAUGE, E | 3 |
| ZETTERSTROEM, R | 1 |
| CENANI, A | 1 |
| FRIEDERISZICK, FK | 1 |
| SALA, G | 1 |
| D AMICO, G | 1 |
| VITERTARI, L | 1 |
| CASTELLUCCIO, A | 1 |
| POLLI, E | 1 |
| PENA, J | 1 |
| RON, J | 1 |
| NESTAL, A | 1 |
| ARMASCRUZ, R | 1 |
| GOMEZ, R | 1 |
| MARDONES, J | 1 |
| PLAZADELOSREYES, M | 1 |
| IRMSCHER, K | 1 |
| BOEHM, P | 1 |
| ZIMMERMANN, H | 1 |
| HERBEUVAL, R | 1 |
| CUNY, G | 1 |
| GUERICI, O | 1 |
| BARBIER, JM | 1 |
| JANDEAUX, M | 1 |
| UHRIN, P | 1 |
| KYSELA, J | 1 |
| GALVANEK, M | 1 |
| FANTATO, S | 1 |
| GILLENWATER, JY | 1 |
| Nielsen, J | 1 |
| Kwon, TH | 1 |
| Praetorius, J | 1 |
| Frøkiaer, J | 1 |
| Knepper, MA | 1 |
| Nielsen, S | 1 |
| Stamoutsos, BA | 1 |
| Carpenter, RG | 1 |
| Grossman, SP | 1 |
| de Groot, CA | 1 |
| Davies, DL | 1 |
| Wilson, GM | 1 |
| Krumlovsky, FA | 1 |
| del Greco, F | 1 |
| Brown, JJ | 1 |
| Lever, AF | 1 |
| Robertson, JI | 1 |
| Reimold, EW | 1 |
| Hepp, KD | 1 |
| Frazier, HS | 1 |
| Yager, H | 1 |
| Sridhar, CB | 1 |
| Calvert, GD | 1 |
| Ibbertson, HK | 1 |
| Anderton, JL | 1 |
| Kincaid-Smith, P | 1 |
| László, FA | 1 |
| Czakó, L | 1 |
| Szijj, I | 1 |
| Kovács, K | 1 |
| Streeten, DH | 1 |
| Speller, PJ | 1 |
3 reviews available for spironolactone and Diabetes Insipidus
| Article | Year |
|---|---|
Diuretics: mechanism of action and clinical application.
Topics: Acute Kidney Injury; Amiloride; Animals; Benzothiadiazines; Diabetes Insipidus; Diuretics; Diuretics | 1975 |
The clinical use of diuretics. 2.
Topics: Acute Kidney Injury; Diabetes Insipidus; Diuretics; Ethacrynic Acid; Furosemide; Humans; Hypertensio | 1973 |
Diuretics. II. Clinical considerations.
Topics: Administration, Oral; Aminophylline; Ascites; Calcium; Carbohydrate Metabolism; Carbonic Anhydrase I | 1971 |
25 other studies available for spironolactone and Diabetes Insipidus
| Article | Year |
|---|---|
Mineralocorticoid regulation of cyclooxygenase-2 expression in rat renal medulla.
Topics: Adrenalectomy; Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Desoxycorticosterone; | 2002 |
[The behavior of the water-mineral balance and urinary aldosterone in diabetes insipidus after administration of aldosterone and spironolactone].
Topics: Aldosterone; Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Diabetes Mellitus; Diuretics; Human | 1961 |
Electrolyte conservation during the treatment of diabetes insipidus with benzothiadiazines.
Topics: Benzothiadiazines; Diabetes Insipidus; Diabetes Mellitus; Diuresis; Electrolytes; Humans; Hydroflume | 1963 |
FLUID AND ELECTROLYTE METABOLISM IN NEPHROGENIC DIABETES INSIPIDUS.TWO CASES.
Topics: Bendroflumethiazide; Child; Diabetes Insipidus; Diabetes Insipidus, Nephrogenic; Diabetes Insipidus, | 1963 |
INVESTIGATIONS INTO THE THIAZIDE-INDUCED ANTIDIURESIS IN PATIENTS WITH DIABETES INSIPIDUS.
Topics: Adolescent; Bendroflumethiazide; Child; Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Diuresis | 1963 |
[FAMILIAL RENAL DIABETES INSIPIDUS. II].
Topics: Blood Chemical Analysis; Chlorides; Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Diagnosis; H | 1963 |
[CLINICAL RESEARCH ON A NEW DIURETIC: TRIAMTERENE].
Topics: Ascites; Diabetes Insipidus; Diuretics; Edema; Humans; Hydrochlorothiazide; Hyperaldosteronism; Live | 1963 |
[THE ANTIDIURETIC EFFECT OF DIURETICS AND ITS APPLICATION TO THE TREATMENT OF DIABETES INSIPIDUS DURING INFANCY. A COMPARATIVE STUDY O BETWEEN TRICHLORMETHIAZIDE, CHLORTHALIDONE AND SPIROLACTONE].
Topics: Adolescent; Antidiuretic Agents; Child; Chlorthalidone; Diabetes Insipidus; Diuresis; Diuretics; Hum | 1963 |
[NATRIURETIC DRUGS].
Topics: Acetazolamide; Aldosterone; Ascites; Chlorothiazide; Dexamethasone; Diabetes Insipidus; Diuresis; Di | 1963 |
[ON THE EFFECT OF SALI-DIURETICS IN DIABETES INSIPIDUS].
Topics: Acetazolamide; Adolescent; Chlorthalidone; Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Diure | 1964 |
[POLYURO-POLYDIPSIC SYNDROME AND CIRRHOSIS. (DISCUSSION APROPOS OF A CASE)].
Topics: Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Diuretics; Humans; Liver Cirrhosis; Polyuria; Sp | 1964 |
[USE OF CHLOROTHIAZIDE DIURETICS AND SPIROLACTONE SC 9420 IN THE TREATMENT OF DIABETES INSIPIDUS IN CHILDREN].
Topics: Child; Chlorothiazide; Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Diuretics; Spironolactone | 1964 |
[POST-TRAUMATIC DIABETES INSIPIDUS AND ITS TREATMENT].
Topics: Adolescent; Arginine Vasopressin; Diabetes Insipidus; Diabetes Insipidus, Neurogenic; Drug Therapy; | 1964 |
ANTIDIURETIC PROPERTIES OF CHLOROTHIAZIDE IN DIABETES INSIPIDUS DOGS.
Topics: Adrenalectomy; Aldosterone; Anuria; Chlorothiazide; Desoxycorticosterone; Diabetes Insipidus; Diazox | 1965 |
Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus.
Topics: Aldosterone; Animals; Aquaporin 2; Cell Membrane; Diabetes Insipidus; Kidney; Kidney Tubules; Lithiu | 2006 |
Role of angiotensin-II in the polydipsia of diabetes insipidus in the Brattleboro rat.
Topics: Angiotensin II; Animals; Captopril; Diabetes Insipidus; Drinking; Furosemide; Male; Quinine; Rats; R | 1981 |
Effects of spironolactone and adrenalectomy on the antipolyuric action of chlorothiazide in Brattleboro rats [proceedings].
Topics: Adrenalectomy; Animals; Chlorothiazide; Diabetes Insipidus; Polyuria; Rats; Spironolactone | 1979 |
Diuretic agents. Mechanisms of action and clinical uses.
Topics: Acute Kidney Injury; Benzothiadiazines; Carbonic Anhydrase Inhibitors; Diabetes Insipidus; Diuretics | 1976 |
Renin in diabetes insipidus.
Topics: Angiotensin II; Diabetes Insipidus; Diuresis; Furosemide; Humans; Infusions, Parenteral; Renin; Spir | 1965 |
[Angiotensin and saluretics in nephrogenic diabetes insipidus of early infancy].
Topics: Angiotensin II; Body Temperature; Chlorthalidone; Diabetes Insipidus; Electrolytes; Female; Furosemi | 1967 |
[Letter: Effect of diuretics in diabetes insipidus].
Topics: Angiotensin II; Benzothiadiazines; Diabetes Insipidus; Diuresis; Diuretics; Ethacrynic Acid; Furosem | 1974 |
Syndrome of hypernatremia, hypodipsia and partial diabetes insipidus: a new interpretation.
Topics: Adolescent; Chlorpropamide; Diabetes Insipidus; Drinking; Female; Humans; Hydrochlorothiazide; Hyper | 1974 |
Studies of the antidiuresis induced by natrichloriuretic drugs in rats with diabetes insipidus.
Topics: Aldosterone; Animals; Bendroflumethiazide; Desoxycorticosterone; Diabetes Insipidus; Diuresis; Femal | 1966 |
Response to saluretics and oral antidiabetics in diabetes insipidus and psychic polydipsia.
Topics: Adolescent; Adult; Chlorothiazide; Chlorpropamide; Creatinine; Diabetes Insipidus; Drug Synergism; F | 1970 |
The role of aldosterone and vasopressin in the postural changes in renal excretion in normal subjects and patients with idiopathic edema.
Topics: Addison Disease; Adolescent; Adrenalectomy; Adult; Aldosterone; Creatine; Dextroamphetamine; Diabete | 1966 |