spironolactone has been researched along with Depression, Endogenous in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To reevaluate whether spironolactone, a steroid receptor antagonist, is effective in improving premenstrual syndrome (PMS) in a double-blind, placebo-controlled cross over study." | 9.08 | Treatment of premenstrual syndrome by spironolactone: a double-blind, placebo-controlled study. ( Bäckström, T; Hammarbäck, S; Lindhe, BA; Wang, M, 1995) |
| "To reevaluate whether spironolactone, a steroid receptor antagonist, is effective in improving premenstrual syndrome (PMS) in a double-blind, placebo-controlled cross over study." | 5.08 | Treatment of premenstrual syndrome by spironolactone: a double-blind, placebo-controlled study. ( Bäckström, T; Hammarbäck, S; Lindhe, BA; Wang, M, 1995) |
| "Spironolactone treatment resulted in a significant increase in cortisol secretion levels in both groups." | 1.32 | Mineralocorticoid receptor function in major depression. ( Akil, H; Lopez, JF; Murphy-Weinberg, V; Watson, SJ; Young, EA, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, EL | 1 |
| Kaplan, PW | 1 |
| Young, EA | 1 |
| Lopez, JF | 1 |
| Murphy-Weinberg, V | 1 |
| Watson, SJ | 1 |
| Akil, H | 1 |
| Khurshid, KA | 1 |
| Weaver, ME | 1 |
| Wang, M | 1 |
| Hammarbäck, S | 1 |
| Lindhe, BA | 1 |
| Bäckström, T | 1 |
1 review available for spironolactone and Depression, Endogenous
| Article | Year |
|---|---|
Caring for transgender patients with epilepsy.
Topics: Androgens; Anti-HIV Agents; Anticonvulsants; Antidepressive Agents; Anxiety Disorders; Comorbidity; | 2017 |
1 trial available for spironolactone and Depression, Endogenous
| Article | Year |
|---|---|
Treatment of premenstrual syndrome by spironolactone: a double-blind, placebo-controlled study.
Topics: Adult; Cross-Over Studies; Depressive Disorder; Double-Blind Method; Female; Humans; Menstrual Cycle | 1995 |
2 other studies available for spironolactone and Depression, Endogenous
| Article | Year |
|---|---|
Mineralocorticoid receptor function in major depression.
Topics: Adult; Circadian Rhythm; Depressive Disorder; Female; Humans; Hydrocortisone; Hypothalamo-Hypophysea | 2003 |
Conn's syndrome presenting as depression.
Topics: Adult; Depressive Disorder; Diagnosis, Differential; Humans; Hyperaldosteronism; Hypokalemia; Male; | 2005 |