spironolactone has been researched along with Deficiency, Magnesium in 12 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our results suggest that reducing cellular magnesium efflux and loss may contribute to the spironolactone-reduced arrhythmias in patients with CHF." | 9.12 | Spironolactone reduced arrhythmia and maintained magnesium homeostasis in patients with congestive heart failure. ( Adhikari, CM; Gao, X; Lin, J; Peng, L; Zuo, Z, 2007) |
| "Six adult patients (4 females and 2 males, age range 26-57 years) with Gitelman's syndrome (GS) were treated with spironolactone 200-300 mg/day (n = 5) and/or amiloride 10-30 mg/day (n = 3) for 1-18 months." | 7.69 | Correction of hypokalemia with antialdosterone therapy in Gitelman's syndrome. ( Colussi, G; De Ferrari, ME; Macaluso, M; Minetti, L; Rombolà, G, 1994) |
| "Serum and muscle electrolytes were determined in a case of primary aldosteronism before and after potassium and magnesium infusions as well as spironolactone treatment and following surgery." | 7.66 | Effects on muscle electrolytes of potassium and magnesium infusions, spironolactone medication and operation in a case of primary aldosteronism. ( Dyckner, T; Wester, PO, 1979) |
| "Our results suggest that reducing cellular magnesium efflux and loss may contribute to the spironolactone-reduced arrhythmias in patients with CHF." | 5.12 | Spironolactone reduced arrhythmia and maintained magnesium homeostasis in patients with congestive heart failure. ( Adhikari, CM; Gao, X; Lin, J; Peng, L; Zuo, Z, 2007) |
| " She was diagnosed to have Gitelman's syndrome with chondrocalcinosis, which were effectively treated with spironolactone and magnesium supplementation." | 3.70 | A case of Gitelman's syndrome with chondrocalcinosis. ( Hashimoto, K; Hisakawa, N; Itoh, H; Jinnouchi, C; Nishiya, K; Takao, T; Yasuoka, N, 1998) |
| "Six adult patients (4 females and 2 males, age range 26-57 years) with Gitelman's syndrome (GS) were treated with spironolactone 200-300 mg/day (n = 5) and/or amiloride 10-30 mg/day (n = 3) for 1-18 months." | 3.69 | Correction of hypokalemia with antialdosterone therapy in Gitelman's syndrome. ( Colussi, G; De Ferrari, ME; Macaluso, M; Minetti, L; Rombolà, G, 1994) |
| "Serum and muscle electrolytes were determined in a case of primary aldosteronism before and after potassium and magnesium infusions as well as spironolactone treatment and following surgery." | 3.66 | Effects on muscle electrolytes of potassium and magnesium infusions, spironolactone medication and operation in a case of primary aldosteronism. ( Dyckner, T; Wester, PO, 1979) |
| "A diagnosis of Gitelman syndrome was made." | 1.37 | Quadriparesis in an adult--Gitelman syndrome. ( Ahmed, S; Farooq, F; Qayyum, M, 2011) |
| "The magnesium deficiency is especially dangerous since it prevents the cells from keeping their high intracellular potassium concentration unchanged." | 1.27 | Potassium-sparing diuretics. ( Dyckner, T; Wester, PO, 1986) |
| "Additional evidence suggests that sudden death may occasionally result from this VEA." | 1.27 | Potassium loss, ventricular irritability, and the risk of sudden death in hypertensive patients. ( Holland, OB, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bandyopadhyay, SK | 1 |
| Datt, S | 1 |
| Pal, SK | 1 |
| Saha, AK | 1 |
| Ahmed, S | 1 |
| Qayyum, M | 1 |
| Farooq, F | 1 |
| Gao, X | 1 |
| Peng, L | 1 |
| Adhikari, CM | 1 |
| Lin, J | 1 |
| Zuo, Z | 1 |
| Colussi, G | 1 |
| Rombolà, G | 1 |
| De Ferrari, ME | 1 |
| Macaluso, M | 1 |
| Minetti, L | 1 |
| Hisakawa, N | 1 |
| Yasuoka, N | 1 |
| Itoh, H | 1 |
| Takao, T | 1 |
| Jinnouchi, C | 1 |
| Nishiya, K | 1 |
| Hashimoto, K | 1 |
| Dyckner, T | 2 |
| Wester, PO | 2 |
| Rowe, WS | 1 |
| Holland, OB | 1 |
| Savoie, LL | 1 |
| Gitelman, HJ | 2 |
| Graham, JB | 2 |
| Welt, LG | 2 |
1 trial available for spironolactone and Deficiency, Magnesium
| Article | Year |
|---|---|
Spironolactone reduced arrhythmia and maintained magnesium homeostasis in patients with congestive heart failure.
Topics: Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Double-Blind Method; Erythrocytes; Exercise | 2007 |
11 other studies available for spironolactone and Deficiency, Magnesium
| Article | Year |
|---|---|
Gitelman's syndrome: a differential diagnosis of normocalcemic tetany.
Topics: Adult; Calcium; Diagnosis, Differential; Diuretics; Female; Gitelman Syndrome; Humans; Magnesium; Ma | 2010 |
Quadriparesis in an adult--Gitelman syndrome.
Topics: Alkalosis; Calcium; Gitelman Syndrome; Humans; Hypokalemia; Magnesium; Magnesium Deficiency; Male; M | 2011 |
Correction of hypokalemia with antialdosterone therapy in Gitelman's syndrome.
Topics: Adult; Aldosterone; Amiloride; Bartter Syndrome; Blood Gas Analysis; Blood Pressure; Creatinine; Dru | 1994 |
A case of Gitelman's syndrome with chondrocalcinosis.
Topics: Bartter Syndrome; Calcium; Chondrocalcinosis; Diagnosis, Differential; Female; Humans; Hypokalemia; | 1998 |
Effects on muscle electrolytes of potassium and magnesium infusions, spironolactone medication and operation in a case of primary aldosteronism.
Topics: Female; Humans; Hyperaldosteronism; Infusions, Parenteral; Magnesium; Magnesium Deficiency; Membrane | 1979 |
Some aspects of diuretic therapy.
Topics: Aged; Amiloride; Benzothiadiazines; Digitalis Glycosides; Diuretics; Drug Therapy, Combination; Etha | 1975 |
Potassium-sparing diuretics.
Topics: Amiloride; Diuretics; Heart Failure; Humans; Hypokalemia; Magnesium Deficiency; Potassium; Spironola | 1986 |
Potassium loss, ventricular irritability, and the risk of sudden death in hypertensive patients.
Topics: Amiloride; Arrhythmias, Cardiac; Death, Sudden; Diuretics; Humans; Hypertension; Hypokalemia; Magnes | 1986 |
[Effect of antikaliuretics on the development of cardiac lesions in potassium or magnesium deficiencies in the rat].
Topics: Amiloride; Animals; Chlorides; Diet; Diuretics; Female; Heart; Heart Diseases; Magnesium; Magnesium | 1971 |
A familial disorder characterized by hypokalemia and hypomagnesemia.
Topics: Calcium; Diuretics; Female; Humans; Kidney; Magnesium; Magnesium Deficiency; Pedigree; Potassium; Po | 1969 |
A new familial disorder characterized by hypokalemia and hypomagnesemia.
Topics: Adult; Diet Therapy; Erythema; Female; Humans; Hypokalemia; Magnesium; Magnesium Deficiency; Middle | 1966 |